Focusing on OB-OC-MΦ Axis and miR-23a to Explore the Pathogenesis and Treatment Strategy of Osteoporosis

Ma, Teng; Zhu, Peng; Ke, Zhuo-Ran; Chen, Jing-Xian; Hu, Yihe; Xie, Jie

doi:10.3389/fendo.2022.891313

Cited by 3 publications

(2 citation statements)

References 141 publications

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“…Osteoporosis is a common chronic orthopedic disease, which is mostly found in the elderly or postmenopausal women [1,2]. Most patients are characterized by a decrease in bone density and abnormal microscopic bone structure, which leads to an increase in bone fragility, which leads to an increase in the risk of fracture [3,4]. The dynamic stability of osteoblasts and osteoclasts is an important condition for maintaining the soundness of normal human bones.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis reveals the key factors affecting the progress of osteoporosis

Huang,

Tang,

Yang

2024

IJPHMR

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The incidence rate of osteoporosis is high, and patients usually have decreased bone density and increased risk of fracture, which seriously affects their quality of life. This study aims to reveal key biomarkers that affect the progression of osteoporosis through bioinformatics methods. This study selected the GSE91033 and GSE93883 datasets for analysis, and obtained differentially expressed miRNAs using the GEO2R analysis tool; Predicting potential miRNA target factors through miRDIP and conducting pathway enrichment analysis of target factors through DAVID database; Analyze the interaction relationships between target factors through the STRING database, and construct a protein interaction network and a miRNA mRNA interaction network. The results showed that 73 and 79 differentially expressed genes were obtained in the GSE91033 and GSE93883 datasets, respectively. Common genes included hsa-miR-4508, hsa-miR-660-5p, and hsa-miR-424-5p. Pathway enrichment analysis showed that downstream target factors of differentially expressed miRNAs involved PIK/AKT, Wnt, Hippo, MAPK, and NF-κB pathway is closely related to cell proliferation and differentiation, and also involves intracellular phosphorylation activity. Protein interaction analysis revealed that CCND1, WEE1, MAP2K1, BTRC, FGF2, AXIN2, PTCH1, CCND2, KIF5C, DYNC1I1 and PAFAH1B1 are node genes involved in the progression of osteoporosis. The miRNA mRNA interaction network revealed that hsa-miR-424-5p is a key factor affecting the progression of osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis reveals the key factors affecting the progress of osteoporosis

Huang,

Tang,

Yang

2024

IJPHMR

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“…discovered that miR-483-5p can increase the progression of osteoporosis following the analysis and comparison of the gene expression profiles of blood and bone tissue samples collected from osteoporotic patients and normal people, the mechanism of which was established as the promotion of osteoclast differentiation [ 82 ]. A number of researchers demonstrated that the high expression of miR-23a exacerbated the pathological damage from osteoporosis by inhibition of osteogenesis, promotion of bone resorption, and inflammatory polarization of macrophages, finally leading to the occurrence and further progression of osteoporosis [ 83 ]. Eric et al .…”

Section: Introductionmentioning

confidence: 99%

Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis

Meng

Yuan

et al. 2023

Cell Div

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Non-coding RNA (ncRNA) is a type of non-protein-coding RNA molecule transcribed from the genome which performs broad regulation of a variety of biological functions in human cells. The Wnt signaling pathway is highly conserved in multicellular organisms, playing an important role in their growth and development. Increasing evidence suggests that ncRNA can regulate cell biological function, enhance bone metabolism, and maintain normal bone homeostasis by interacting with the Wnt pathway. Studies have also demonstrated that the association of ncRNA with the Wnt pathway may be a potential biomarker for the diagnosis, evaluation of prognosis, and treatment of osteoporosis. The interaction of ncRNA with Wnt also performs an important regulatory role in the occurrence and development of osteoporosis. Targeted therapy of the ncRNA/Wnt axis may ultimately be the preferred choice for the treatment of osteoporosis in the future. The current article reviews the mechanism of the ncRNA/Wnt axis in osteoporosis and reveals the relationship between ncRNA and Wnt, thereby exploring novel molecular targets for the treatment of osteoporosis and providing theoretical scientific guidance for its clinical treatment.

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Current ideas on the pathogenesis of osteoporosis in chronic lymphatic leukemia (literature review)

Osikov,

Korobkin,

Fedosov

et al. 2024

Acta biomedica scientifica

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Background. Chronic lymphocytic leukemia (CLL) is the second most common hematological malignancy without a trend towards a decrease in its incidence. 66 % of patients with CLL experience bone fractures as a result of osteoporosis in all age groups, and the detection frequency is no more than 15 %. Insufficient understanding of the osteoporosis pathogenesis in CLL leads to problems in diagnosis, prevention and therapy.The aim of the study. To analyze modern data on the features of the osteoporosis pathogenesis in chronic lymphocytic leukemia.Results and discussion. Osteoporosis is formed when osteoresorption prevails over osteosynthesis due to intercellular interactions of bone tissue and the immune system, dysregulation of intracellular signaling pathways RANKL/RANK/OPG, Wnt, FoxO, RUNX2, initiated by cytokines, growth factors, prostaglandins, and hormones. The degree of osteoresorption in CLL is associated with the severity of the clinical course, chemotherapy and hormonal deprivation. The osteoporosis pathogenesis in CLL is considered as part of a complex set of events, including, firstly, the interaction between leukemic cells (overexpression of PTHrP, RANKL) and bone cells (synthesis of growth factors), which forms a vicious circle of osteoresorption and tumor growth. Secondly, pro-inflammatory markers in CLL (tumor necrosis factor α, interleukin (IL) 1β, IL-6, IL-8, IL-11, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, transforming growth factor β, prostaglandin E2) limit osteoblast-induced osteosynthesis and stimulate the expansion of osteoclasts from monocytic suppressor cells of myeloid origin with or without the participation of the RANKL/RANK system. Thirdly, oxidative stress in CLL and impaired efficiency of antioxidant protection with the participation of fibroblast growth factor 23, transcription factor Nrf-2 with activation of JNK, ERK1/2, NF-κB, and also an increase in the RANKL/OPG ratio lead to inhibition of osteoblastogenesis.Conclusion. Analyzing and systematizing data on the osteoporosis pathogenesis in CLL are instrumental for the development of diagnostic criteria for osteoporosis in chronic lymphocytic leukemia that are much-needed in clinical practice and for the improvement of therapeutic tactics.

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Focusing on OB-OC-MΦ Axis and miR-23a to Explore the Pathogenesis and Treatment Strategy of Osteoporosis

Cited by 3 publications

References 141 publications

Bioinformatics analysis reveals the key factors affecting the progress of osteoporosis

Bioinformatics analysis reveals the key factors affecting the progress of osteoporosis

Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis

Current ideas on the pathogenesis of osteoporosis in chronic lymphatic leukemia (literature review)

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