Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet

Seo, Jong Bae; Choe, Sung Sik; Jeong, Hyun Woo; Park, Jae Young; Choi, Eun-Wook; Seen, Dong-Seung; Jeong, Jae Yeon; Lee, Tae Gyu

doi:10.1016/j.bbrc.2011.12.039

Cited by 25 publications

(25 citation statements)

References 18 publications

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“…Hence, administration of FRG could reduce hepatic lipid deposition to prevent the occurrence of fatty liver. Generally, hypertrophy and fatty change of hepatocytes induced by high-fat diet are accompanied by increased AST and ALT activities [2627]. The present results showed that FRG ameliorated hepatic steatosis by regulating lipid metabolism, and exhibited protective effects on hepatic structure.…”

Section: Discussionmentioning

confidence: 50%

Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

et al. 2016

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This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats were divided into four groups of seven: normal control, NC; high-fat diet control, HFC; high-fat diet–0.5% FRG, HF-FRGL; and high-fat diet–1% FRG, HF-FRGH. All rats were fed a high-fat diet for eight weeks, except those in the NC group, while rats in the FRG treatment groups received drinking water containing 0.5% or 1% FRG. After eight weeks of treatment, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C) in the serum were measured. The concentration of the oxidative stress marker malondialdehyde (MDA), and activity of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in rat liver were evaluated. Histological analysis of the liver was performed using hematoxylin and eosin. The high-fat diet markedly increased serum levels of ALT, AST, TC, TG, and LDL-C and hepatic MDA levels, while administration of FRG to the hyperlipidemic rats resulted in a significant decline in the levels of these parameters. Furthermore, the decline in the levels of serum HDL-C and hepatic SOD, CAT, and GSH-Px induced by the high-fat diet was attenuated by FRG treatment. In addition, histopathological analysis of liver sections suggested that FRG treatment also provided protection against liver damage. These results suggested that FRG improved lipid profiles, inhibited lipid peroxidation, and played a protective role against liver injury in hyperlipidemic rats.

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Section: Discussionmentioning

confidence: 50%

Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

et al. 2016

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“…Generally, hypertrophy and fatty change of hepatocytes are accompanied by increased AST and ALT activities in HFD-fed mice [35,36]. In addition, chronic metabolic disorders involving diabetes increase the risk of inflammation and fatty changes in kidney, and thereby elevate the level of BUN and creatinine by renal dysfunction [37].…”

Section: Discussionmentioning

confidence: 99%

Red-Koji Fermented Red Ginseng Ameliorates High Fat Diet-Induced Metabolic Disorders in Mice

Kim

Cho

et al. 2013

Nutrients

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Fermentation of medicinal herbs improves their pharmacological efficacy. In this study, we investigated the effects of red-koji fermented red ginseng (fRG) on high-fat diet (HFD)-mediated metabolic disorders, and those effects were compared to those of non-fermented red ginseng (RG). fRG (500, 250 or 125 mg/kg), RG (250 mg/kg), simvastatin (10 mg/kg), silymarin (100 mg/kg) and metformin (250 mg/kg) were orally administered from 1 week after initiation of HFD supply for 84 days. The diameter of adipocytes in periovarian and abdominal fat pads and the thickness of the abdominal fat were significantly decreased by fRG treatment, while HFD-mediated weight gain was partly alleviated by fRG in a dose-dependent manner. Moreover, biochemical and histomorphometrical analyses clearly indicated that fRG significantly inhibited HFD-induced metabolic disorders such as hyperglycemia, hyperlipidemia, hepatopathy and nephropathy in a dose-dependent manner. More favorable pharmacological effects on HFD-mediated metabolic disorders were also observed with fRG compared to an equal dose of RG. This finding provides direct evidence that the pharmacological activities of RG were enhanced by red-koji fermentation, and fRG could be a neutraceutical resource for the alleviation of obesity-mediated metabolic disorders.

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“…Furthermore, Foenumoside B from Lysimamachia foenum-graecum, an herbal plant used as a traditional oriental medicine, has been reported to inhibit adipocyte differentiation by activating AMPK and regulating the expression of genes involved in lipid metabolism. 17) Even though the component that exerts antiobesity effect has not yet been characterized, the flavonoids in VN extract may contribute to the antiobesity effect of V. nakashimae. Further study is needed to characterize the component that has the antiobesity effect of V. nakashimae extract.…”

Section: Discussionmentioning

confidence: 99%

Antiobesity Activity of <i>Vigna nakashimae</i> Extract in High-Fat Diet-Induced Obesity

Son

Nam

Jang

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet

Cited by 25 publications

References 18 publications

Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

Red-Koji Fermented Red Ginseng Ameliorates High Fat Diet-Induced Metabolic Disorders in Mice

Antiobesity Activity of <i>Vigna nakashimae</i> Extract in High-Fat Diet-Induced Obesity

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