BACKGROUND Nearly three fourth of all neonatal deaths and half of infant deaths occur among LBW infants. A progressive increase in both perinatal mortality and morbidity is observed as birth weight percentile falls. Early detection of intrauterine growth restriction is therefore important to institute specific treatment wherever possible or appropriately time the delivery. In a developing country like India, a simple sensitive clinical method is of utmost importance and cost effective. Hence this study is conducted to find the efficacy of clinical methods in detection of IUGR and estimation of foetal weight in relation to ultrasound. METHODS A longitudinal study of 200 low risk pregnant women who are attending the antenatal clinic with dating USG after 24 weeks of pregnancy were included in the study and serial symphysis fundal height measurements at each antenatal visit are taken. Suspected cases of growth restriction were subjected to USG for assessment and managed as per institutional protocol. Birth weight was compared with clinical and sonologically estimated weight. The entire data is statistically analysed using Statistical Package for Social Sciences (SPSS Ver. 21.0, IBM Corporation, USA) for MS Windows. RESULTS The sensitivity, specificity, PPV, NPV and accuracy of clinical method (abdominal palpation), clinical method (SFH), and USG method (abdominal circumference) USG method (Estimated Foetal Weight) in detecting IUGR was 80-95% and their agreement with birth weight was statistically significant. The distribution of mean estimated weight by Johnson's formula is significantly higher compared to actual mean birth weight (p-value<0.001). The distribution of mean estimated weight by USG is significantly higher compared to actual mean birthweight (p-value<0.001). Since the mean difference in the weight is relatively lesser with narrow 95% confidence interval by USG than Johnson's formula, USG method has relatively better method than Johnson's formula for estimation of weight. CONCLUSIONS The efficacy of serial symphysio-fundal height measurement was found to be comparable with ultrasound in detection of IUGR. Of the two methods studied for estimation of foetal weight, ultrasonographic method, i.e., Hadlock's formula has better predictable results in foetal weight estimation, compared to clinical method, i.e., Johnson's formula.