Foetal intrauterine growth restrictions with Helicobacter pylori infection

Abstract

SUMMARYBackground: Helicobacter pylori infection has been associated with growth restriction in young children. Aim: To determine whether there is an association between H. pylori infection and intrauterine growth restriction. Methods: Four hundred and forty-eight consecutive pregnant women (aged 15-44 years), attending for routine examinations in the third trimester, were enrolled. Clinical, demographic and previous obstetric data, as well as smoking history, were collected. At delivery, the weight, height, gender and status of the neonate were recorded; intrauterine growth restriction was defined if the birth weight was below the 10th percentile according to the gestational age for infants born in Australia. Results: Eighty-nine (20%) women were seropositive for H. pylori. The prevalence of H. pylori was significantly

The infectious etiology of the antiphospholipid syndrome: links between infection and autoimmunity

“…It is a common bacterial pathogen that colonizes the gastric mucosa in humans and induces chronic gastric inflammation. In pregnant women H. pylori infection can cause intrauterine fetal growth retardation (Eslick et al, 2002), increase the risk of reproductive disorders (Figura et al, 2002), and induce cerebral ischemia (Grau et al, 2001) and coronary heart disease (Pellicano et al, 1999). A screen of 50 patients with H. pylori infection has revealed 33.3% prevalence of anti-b2GPI antibodies (Sorice et al, 2000).…”

Helicobacter pylori and Perinatal Pathologies: Pathogen Transmission During Childbirth?

“…Hyperemesis gravidarum [8][9][10][11][12] Preeclampsia [13][14][15]23] Iron-deficiency Anemia [16][17][18][19] Intrauterine growth Restriction [20][21][22]27] Spontaneous abortion [24][25][26] and inflammatory damage over the gastric epithelium resulting in gastrointestinal disturbance such as hyperemesis gravidarum. H. pylori sequesters essential micronutrients from the host organism such as Iron (Fe) and it causes iron deficiency anemia.…”

“…In Australia in 2002, Eslick et al [21] observed an association with H. pylori infection and low birth weight for the first time and they showed that intra-uterine growth restriction was more common in H. pylori seropositive women (13.5%) compared to seronegative women (6.0%).…”

Infecção pelo helicobacter pylori e sua correlação com os sintomas dispépticos e evolução da gravidez

“…Por outro lado, já foi sugerido ser a presença de infecção pelo H. pylori fator de risco para o desenvolvimento intra-uterino do feto 12 . Em nosso meio, raras são as pesquisas sobre a prevalência do H. pylori em gestantes 13 ; da mesma maneira, eventual correlação da positividade sorológica para anticorpos IgG do H. pylori com os sintomas dispépticos na gravidez e com diferentes caracterís-ticas maternas, ainda carece de investigação.…”