Foetal microchimerism occurs in pigs

Wang, Zhengzhu; Han, Zhiqiang; Wang, Jing; Gu, Shigang; Zhou, Yongfeng; Han, Zhen; Zhai, Yanhui; Zhang, Sheng; An, Xinglan; Yu, Debing; Hu, Zheng; Hai, Tang; Li, Ziyi

doi:10.1111/cpr.13333

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…A second type is maternal microchimerism, where the transfer of maternal cells and components is established in the fetus. Similarly, some works have shown maternal chimeric cells in organs such as lymph nodes (cellular structure that form part of the lymphatic system), intestines, lungs, spleen, and brain 12 . Interestingly, the transport of fetal cells to maternal circulation is greater than the transport of maternal cells to fetal circulation, so the mother usually has higher rates of microchimerism than the newborn 13 .…”

Section: Micochimerism As a Bi-directional Motherfetus Communicationmentioning

confidence: 91%

Microchimerism and lactation: a long-lasting immunologic legacy from mother to child

Bermejo-Haro,

Maldonado-Ibarra,

Camacho-Pacheco

et al. 2024

PERE

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The interaction between mother and fetus during pregnancy has been extensively studied. One of these interactions is the microchimerism, which is characterized by a mother-fetus exchange of cells and genetic material. In addition to gestation, the mother inherits more cells through lactation, in which biocomponents (cells, antibodies, and commensal bacteria) that play an important role in the adaptation of the newborn to the environment are transferred. The consequences of this post-partum microchimerism generate direct benefits in the first months of life, preventing diseases and infections, inducing tolerance to innocuous molecules, as well as favoring the immunological training of the newborn, with specialized responses and benefits in adult life. It is noteworthy that maternal microchimerism could be interpreted as an immunological legacy in the neonate, which is lasting for some of its components, and defining in the correct development of the progeny.

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Section: Micochimerism As a Bi-directional Motherfetus Communicationmentioning

confidence: 91%

Microchimerism and lactation: a long-lasting immunologic legacy from mother to child

Bermejo-Haro,

Maldonado-Ibarra,

Camacho-Pacheco

et al. 2024

PERE

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Presence of fetal microchimerisms in the heart and effect on cardiac repair

Llorente,

López-Olañeta,

Blázquez-López

et al. 2024

Front. Cell Dev. Biol.

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Multiple complex biological processes take place during pregnancy, including the migration of fetal cells to maternal circulation and their subsequent engraftment in maternal tissues, where they form microchimerisms. Fetal microchimerisms have been identified in several tissues; nevertheless, their functional role remains largely unknown. Different reports suggest these cells contribute to tissue repair and modulate the immune response, but they have also been associated with pre-eclampsia and tumor formation. In the maternal heart, cells of fetal origin can contribute to different cell lineages after myocardial infarction. However, the functional role of these cells and their effect on cardiac function and repair are unknown. In this work, we found that microchimerisms of fetal origin are present in the maternal circulation and graft in the heart. To determine their functional role, WT female mice were crossed with male mice expressing the diphtheria toxin (DT) receptor. Mothers were treated with DT to eliminate microchimerisms and the response to myocardial infarction was investigated. We found that removal of microchimerisms improved cardiac contraction in postpartum and post-infarction model females compared to untreated mice, where DT administration had no significant effects. These results suggest that microchimerisms play a detrimental role in the mother following myocardial infarction.

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Foetal microchimerism occurs in pigs

Abstract: To the Editor,The presence of a tiny population of foreign cells or DNA in an organism is known as microchimerism. Microchimerism can occur as a result

Cited by 2 publications

References 23 publications

Microchimerism and lactation: a long-lasting immunologic legacy from mother to child

Microchimerism and lactation: a long-lasting immunologic legacy from mother to child

Presence of fetal microchimerisms in the heart and effect on cardiac repair

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