Fokussuche bei Patienten mit Fieber unklarer Genese: Ist die Positronen-Emissions-Tomographie mit F-18-Fluordesoxyglukose hilfreich?

Lorenzen, Johan M.; Buchert, Ralph; Bleckmann, C.; Münchow, N; Kh, Bohuslavizki

doi:10.1055/s-1999-9892

Cited by 12 publications

(4 citation statements)

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“…These conditions have not been well documented to date. However, in one report (13), patients with fever of unknown origin presented with high FDG uptake in PET imaging, finally proved to be infected by pneumocystis carinii pneumoniae. Inflammatory cells increase the expression of glucose transporters when they are activated, and multiple cytokines and growth factors can facilitate glucose transport without actually increasing the number of glucose transporters (5).…”

Section: False Positive Findingsmentioning

confidence: 99%

False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases

et al. 2006

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Fluorodeoxyglucose (FDG)-positron emission tomography (PET) is being used more and more to differentiate benign from malignant focal lesions and it has been shown to be more efficacious than conventional chest computed tomography (CT). However, FDG is not a cancer-specific agent, and false positive findings in benign diseases have been reported. Infectious diseases (mycobacterial, fungal, bacterial infection), sarcoidosis, radiation pneumonitis and post-operative surgical conditions have shown intense uptake on PET scan. On the other hand, tumors with low glycolytic activity such as adenomas, bronchioloalveolar carcinomas, carcinoid tumors, low grade lymphomas and small sized tumors have revealed false negative findings on PET scan. Furthermore, in diseases located near the physiologic uptake sites (heart, bladder, kidney, and liver), FDG-PET should be complemented with other imaging modalities to confirm results and to minimize false negative findings. Familiarity with these false positive and negative findings will help radiologists interpret PET scans more accurately and also will help to determine the significance of the findings. In this review, we illustrate false positive and negative findings of PET scan in a variety of diseases.

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Section: False Positive Findingsmentioning

confidence: 99%

False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases

et al. 2006

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“…Although FDG-PET may not discriminate between a tuberculous abscess and a bacterial abscess, it can screen the whole body of the patient with a brain abscess to detect other tuberculous lesions [12][13][14]. Soft tissue and pulmonary infections can be visualized even before the development of chest radiograph abnormalities [14].…”

Section: Discussionmentioning

confidence: 99%

“…Soft tissue and pulmonary infections can be visualized even before the development of chest radiograph abnormalities [14]. Cerebral biopsy is invasive and carries a signifi cant risk.…”

Section: Discussionmentioning

confidence: 99%

Positron emission tomographic findings in a tuberculous brain abscess

2007

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Several case reports and studies have described the positron emission tomographic (PET) findings of intracranial tuberculomas and bacterial brain abscesses. However, to our knowledge, the PET pattern of a tuberculous brain abscess has not been previously described. We report the case of a diabetic heavy drinker with a left parietal tuberculous abscess. (18)F-fluoro-2-deoxyglucose (FDG)-PET scans showed intense FDG uptake at the abscess periphery, where contrast enhancement was observed on a magnetic resonance image. FDG uptake was reduced within the abscess cavity and in the adjacent cerebral cortex. The possibility of a tuberculous brain abscess should be considered when FDG accumulates at the periphery of a ring-enhancing lesion in a chronically ill or immunocompromised patient.

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“…Tüberküloza ek olarak kriptokok, paragonimiyazis ve pnömosistis karini enfeksiyonlarında da artmış FDG tutulumunun izlendiği bildirilmiştir (13)(14)(15). Bu durum her ne kadar malign lezyonların değerlendirmesinde bir yalancı pozitiflik olarak görülse de diğer taraftan enfeksiyon odağı araştırılmasında, tedavi takibinde vb.…”

Section: Tüberkülozunclassified

Utility Of Pet In Benign Thoracic Disorders

Vatankulu¹,

Halaç²

2015

Toraks Cer Bult

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Abstract18F-FDG is a measure of glucose metabolism used in PET imaging. FDG-PET and PET/CT are the most important modalities in tumor imaging. They are used in the differentiation of benign from malignant lesions, staging of malignant lesions, assessment of treatment response, and follow-up of patients after therapy. However, several benign conditions can show increased FDG accumulation and therefore show false-positive results for malignancy. These can be broadly categorized as infectious disorders (mycobacterial, fungal, and bacterial infection), active granulomatous disease (such as sarcoidosis), and other non-infectious inflammatory conditions (e.g., radiation pneumonitis, post-lung transplant lymphoproliferative processes, occupational pleuropulmonary complications, and post-surgical conditions). All these benign conditions can demonstrate varying degrees of FDG uptake on PET and PET/CT on account of a reactive inflammatory response. It is proposed that overexpression of glucose transporters in inflammatory cells such as activated macrophages, neutrophils, and lymphocytes at the site of inflammation or infection is responsible for the accumulation of FDG. On the other hand, these conditions can be used for exploring the potential utility of FDG-PET; PET/CT can be useful in the evaluation of benign thoracic disorders, such as diagnosis of the disease, identifying potential diagnostic biopsy sites, and detecting disease in unsuspected anatomic locations, as well as have a role in monitoring the therapeutic response.

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Fokussuche bei Patienten mit Fieber unklarer Genese: Ist die Positronen-Emissions-Tomographie mit F-18-Fluordesoxyglukose hilfreich?

Abstract: Successful implementation of F-18-FDG-PET as additional imaging method in patients with FUO seems reasonable. This has to be verified by further prospective studies.

Cited by 12 publications

References 0 publications

False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases

False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases

Positron emission tomographic findings in a tuberculous brain abscess

Utility Of Pet In Benign Thoracic Disorders

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