Folate and cobalamin in psychiatric illness

Hutto, Burton

doi:10.1016/s0010-440x(97)90925-1

Cited by 150 publications

(82 citation statements)

References 49 publications

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“…Double-blind, placebo-controlled studies show that thiamin supplementation improves composure, mood and clarity of thought, even in subjects who are classified as having adequate thiamin status (11,43) . Fortified breakfast cereals are also good sources of folate and Fe, which are used in the synthesis of serotonin (44) and other neurotransmitters (45) ; Fe is additionally used to bind neurotransmitters to receptors in the brain (46) . An increased intake of valuable vitamins and minerals at the start of the day, resulting from consumption of a breakfast with a variety of food groups, may partially explain the relationship with better mental health that was observed in our study.…”

Section: Discussionmentioning

confidence: 99%

A good-quality breakfast is associated with better mental health in adolescence

O’Sullivan

Robinson

Kendall

et al. 2009

Public Health Nutr.

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Objective: Breakfast consumption has been associated with better mental health in adulthood, but the relationship between breakfast and mental health in adolescence is less well known. The aims of the present study were to evaluate breakfast quality in a cohort of adolescents and to investigate associations with mental health. Design: Cross-sectional population-based study. Breakfast quality was assessed by intake of core food groups at breakfast, as determined from 3 d food diaries. Mental health was assessed using the Child Behaviour Checklist (CBCL), with higher scores representing poorer behaviour. Setting: The Western Australian Pregnancy Cohort (Raine) Study, Perth, Western Australia. Subjects: Eight hundred and thirty-six males and females aged between 13 and 15 years. Results: Mean mental health score as assessed by the CBCL was 45?24 (SD 11?29). A high-quality breakfast consisting of at least three food groups was consumed by 11 % of adolescents, while 7 % of adolescents did not consume any items from core food groups on average over the 3 d period. The two most common core food groups consumed at breakfast in this population were dairy products followed by breads and cereals. For every additional food group eaten at breakfast, the associated total mental health score decreased by 1?66 (95 % CI 22?74, 20?59) after adjustment for potential confounding factors, representing an improvement in mental health score. Conclusion: These findings support the concept that breakfast quality is an important component in the complex interaction between lifestyle factors and mental health in early adolescence.

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Section: Discussionmentioning

confidence: 99%

A good-quality breakfast is associated with better mental health in adolescence

O’Sullivan

Robinson

Kendall

et al. 2009

Public Health Nutr.

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“…Por exemplo, a deficiência de vitamina B1 (tiamina), com prevalência estimada de 1% entre o segundo e quinto mês de pós-operatório de cirurgia disabsortiva, pode levar agudamente à encefalopatia de Wernicke e, posteriormente, à sín-drome de Korsakoff. Deficiência de vitamina B12 (cobalamina) e B9 (ácido fólico) está estimada em 12%-33% após bypass gástrico em Y de Roux 68 , condição envolvida no surgimento de diversos sintomas neurológicos e depressivos 70,71 . Deficiência de ferro e proteínas, com incidência de 14%-16% após bypass gástrico em Y de Roux e 21%-26% após bypass jejuno-ileal 67 , está relacionada a diversos sintomas encontrados em síndromes depressivas: irritabilidade, astenia, fadiga, insônia e déficit cognitivo.…”

Section: Seguimento Pós-operatóriounclassified

Aspectos do acompanhamento psiquiátrico de pacientes obesos sob tratamento bariátrico: revisão

Gordon

Kaio²,

Sallet³

2011

Rev. psiquiatr. clín.

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ResumoContexto: Nas últimas décadas, diversos estudos longitudinais têm demonstrado a eficácia da cirurgia bariátrica no controle de peso em longo prazo e na redução da mortalidade resultante de complicações clínicas associadas à obesidade. Contudo, os estudos também revelam aumento significativo da mortalidade devida a suicídio e comportamento impulsivo, por razões largamente desconhecidas, o que demonstra a escassez de informações relativas ao manejo clínico de pacientes bariátricos. O presente estudo tem como objetivo sintetizar o estado atual de conhecimentos referentes ao acompanhamento psiquiátrico de pacientes bariátricos. Método: Revisão seletiva da literatura envolvendo artigos indexados no Medline e PubMed até junho de 2010, utilizando-se os termos: "bariatric surgery", "psychiatry", "binge eating", "follow-up" e "outcome". Resultados: Há relativo consenso na literatura de que não haja contraindicação psiquiátrica absoluta para a cirurgia bariátrica, embora a avaliação pré-operatória seja de extrema importância para o diagnóstico e tratamento de eventuais transtornos psiquiátricos, objetivando assegurar aderência ao tratamento multidisciplinar, melhor qualidade de vida e, possivelmente, melhor prognóstico pós-cirúrgico. Entre os transtornos mais prevalentes nessa população, encontra-se o transtorno da compulsão alimentar periódica (TCAP), que está relacionado com menor perda ponderal e pior qualidade de vida, especialmente quando presente no pós-operatório. No acompanhamento pós-operatório, também se deve atentar para o surgimento de sintomas impulsivos, incluindo abuso de álcool e outras substâncias. Conclusão: Diversos estudos indicam elevada prevalência de transtornos mentais e alterações psicopatológicas na população de pacientes bariátricos. Embora a maioria dos pacientes apresente adequado controle ponderal e melhora na qualidade de vida em médio e longo prazo, alguns pacientes desenvolvem alterações relativas ao comportamento alimentar, abuso de álcool e outras substâncias e complicações associadas a comportamento impulsivo, o que remete a hipóteses etiológicas que vão desde modelos neuroquímicos até teorias psicossociais. Por todas essas razões, é de fundamental importância que os profissionais de saúde mental integrem as equipes que avaliam e acompanham os pacientes bariátricos. Gordon PC, et al. / Rev Psiq Clín. 2011;38(4):148-54Palavras-chave: Obesidade, cirurgia bariátrica, psiquiatria, transtorno da compulsão alimentar periódica. AbstractBackground: In recent decades, several longitudinal studies show the efficacy of bariatric surgery on long-term weight control and reductions in mortality due to clinical complications associated with obesity. However, studies also show significantly increased mortality due to suicide and impulsive behavior, for reasons largely unknown, which demonstrates the paucity of information concerning the clinical management of bariatric patients. This study aims to synthesize the current state of knowledge regarding the psychiatric care of bariatric patients. Meth...

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“…Its anti-anaemic function has been known for years. Recent studies have shown that appropriate amount of vitamin B 12 can protect against dementia 1,2 , boost immune function and maintain the nervous system 3 . Also, vitamin B 12 lowers homocysteine levels and protects against atherosclerosis and other cardiovascular disease 4,5 , as well as certain neurological diseases associated with increased homocysteine including Alzheirmer's diseases 6,7 ; depression and schizophrenia 8 .…”

Section: Introductionmentioning

confidence: 99%

Vitamin b<sub>12</sub> supplementation: effects on some biochemical and haematological indices of rats on phenytoin administration

Akaidem¹,

Akpanabiatu²,

Uboh³

et al. 2010

Biokemistri

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Phenytoin is known to have some toxicological implications. Vitamin B 12 supplementation during phenytoin administration was investigated to assess the benefits and risks of single vitamin supplementation. This study evaluated the biochemical and haematological effects of vitamin B 12 on phenytoin toxicity. Twenty-four experimental animals were divided into 3 groups of 8 rats each. The control (group 1) received distilled water as placebo. Groups 2 and 3 were given 5mg/kg body weight of phenytoin for 4 weeks while group 3 in addition to phenytoin received intra-peritoneal administration of 15 g/kg body of vitamin B 12 twice a week. Biochemical parameters such as AST, ALT, ALP, lipid profile and haematological indices were assayed as indices of toxicity. The result of the study showed that phenytoin administration resulted in anaemia which was ameliorated by vitamin B 12 co-administration. Phenytoin also increased significantly the leukocyte count upon which B 12 had no effect. Liver enzymes activities were significantly (p<0.05) raised during phenytoin administration and interestingly B 12 further increased the level of these enzymes. Administration of phenytoin only gave a significant (p<0.05) increase in the level of serum Low density lipoprotein cholesterol. Serum cholesterol, TG and HDL-chol were not significantly affected. Although there was no significant change in serum cholesterol, the slight increase was more than 1% which is capable of causing a 3% increase in the risk of coronary heart disease. A significant decrease was also noted when phenytoin was supplemented with B 12 . We observed that vitamin B 12 co-administration is beneficial in remitting anaemia and the atherosclerotic risk caused by phenytoin but may enhance hepatotoxicity. By this result we would therefore suggest that the use of vitamin B 12 alone as supplement during phenytoin administration be discouraged.

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Folate and cobalamin in psychiatric illness

Cited by 150 publications

References 49 publications

A good-quality breakfast is associated with better mental health in adolescence

A good-quality breakfast is associated with better mental health in adolescence

Aspectos do acompanhamento psiquiátrico de pacientes obesos sob tratamento bariátrico: revisão

Vitamin b<sub>12</sub> supplementation: effects on some biochemical and haematological indices of rats on phenytoin administration

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