Folate and Cobalamin Serum Levels in Healthy Children and Adolescents and Their Association with Age, Sex, BMI and Socioeconomic Status

Background Previous studies indicate that serum folate is inversely associated with metabolic syndrome (MetS). This study aims to investigate the association between serum folate, homocysteine (Hcy) levels, and cardiometabolic risk in patients with type 2 diabetes (T2D). Methods Associations between serum folate, Hcy levels, and cardiometabolic risk factors were assessed in a cross-sectional study of 755 participants with T2D. Results In individuals with MetS, the serum folate levels were significantly lower than in subjects without MetS, whereas the serum Hcy was significantly higher. Serum folate level was negatively correlated with CRP, body mass index (BMI), serum Hcy, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), serum uric acid (UA), and diastolic blood pressure (DBP) but positively correlated with high-density lipoprotein cholesterol (HDL-C). Furthermore, serum Hcy concentrations were positively correlated with BMI, UA, total cholesterol, TG, and LDL-C. A multiple linear regression analysis was used to identify predictors for cardiometabolic risk. Low serum folate levels were identified as an independent risk factor for obesity and dyslipidemia in patients with T2D. Moreover, high serum Hcy levels were positively associated with serum UA and hypertension after adjusting for potential confounders. Conclusion Low serum folate levels was an independent risk factor for obesity and dyslipidemia in the T2D population. High Hcy levels were positively associated with serum UA and hypertension.

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“…A recent study reported that serum folate is inversely correlated with BMI in healthy adolescents [20].…”

Section: Discussionmentioning

confidence: 98%

Serum folate and homocysteine levels are associated with cardiometabolic risk factors in patients with type 2 diabetes

Men

Jin

Yan

et al. 2022

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“…The BMI-SDS was calculated using BMI, sex, and age in months to assess the BMI in an age- and sex-dependent manner, as described in details previously [ 16 ]. The patients were classified as underweight (BMI-SDS < − 1.28), normal weight (BMI-SDS − 1.28 to 1.279), and overweight or obesity (BMI-SDS ≥ 1.28) [ 17 , 18 ]. The CCCs were calculated based on the number of diseases among 12 disease categories to adjust for the severity of comorbidities on admission, as previously described [ 15 , 19 ].…”

Section: Methodsmentioning

confidence: 99%

Major complications after percutaneous biopsy of native or transplanted liver in pediatric patients: a nationwide inpatient database study in Japan

et al. 2022

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Aim Although major complication rates following percutaneous liver biopsy (PLB) have been reported to be higher in children than in adults, scarce data are available regarding pediatric patients stratified by native and transplanted liver. We aimed to assess the factors associated with major complications after percutaneous biopsy of native or transplanted liver using a nationwide inpatient database. Methods Using the Japanese Diagnosis Procedure Combination database, we retrospectively identified pediatric patients who underwent PLB between 2010 and 2018. We described major complication rates and analyzed factors associated with major complications following PLB, stratified by native and transplanted liver. Results We identified 3584 pediatric PLBs among 1732 patients from 239 hospitals throughout Japan during the study period, including 1310 in the native liver and 2274 in the transplanted liver. Major complications following PLB were observed in 0.5% (n = 18) of the total cases; PLB in the transplanted liver had major complications less frequently than those in the native liver (0.2% vs. 1.0%, p = 0.002). The occurrence of major complications was associated with younger age, liver cancers, unscheduled admission, anemia or coagulation disorders in cases with native liver, while it was associated with younger age alone in cases with transplanted liver. Conclusions The present study, using a nationwide database, found that major complications occurred more frequently in pediatric cases with native liver and identified several factors associated with its major complications.

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“…Studies on optimal serum concentrations in healthy European children are still scarce, and no universally accepted cut-offs have been established [ 87 ].…”

Section: Micronutrients Deficiency In Childhood Obesitymentioning

confidence: 99%

Micronutrient Deficiency in Children and Adolescents with Obesity—A Narrative Review

et al. 2023

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Childhood obesity represents a serious public health burden. Despite excessive dietary consumption, children with obesity present high rates of micronutrient deficiencies, such as deficiencies in minerals and specific vitamins; micronutrient deficiencies may have a pathogenic role in obesity-related metabolic comorbidities. In this narrative review, we analyzed the main deficiencies associated with obesity, their clinical consequences, and the evidence about a possible supplementation. Iron; vitamins A, B, C, D, and E; folic acid; zinc; and copper deficiencies represent the most common deficient microelements. The relationship between obesity and multiple micronutrient deficiencies remains unclear, and different mechanisms have been proposed. The medical care plan for pediatric obesity should include food choices with high nutritional content as part of a crucial approach to obesity-related complications. Unfortunately, only a few studies are available regarding the efficacy of oral supplementation or weight loss for treating them; thus, continuous nutritional monitoring is necessary.

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Folate and Cobalamin Serum Levels in Healthy Children and Adolescents and Their Association with Age, Sex, BMI and Socioeconomic Status

Cited by 24 publications

References 45 publications

Serum folate and homocysteine levels are associated with cardiometabolic risk factors in patients with type 2 diabetes

Serum folate and homocysteine levels are associated with cardiometabolic risk factors in patients with type 2 diabetes

Major complications after percutaneous biopsy of native or transplanted liver in pediatric patients: a nationwide inpatient database study in Japan

Micronutrient Deficiency in Children and Adolescents with Obesity—A Narrative Review

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