Folate-based radiotracers for nuclear imaging and radionuclide therapy

Wagner, Laurène; Kenzhebayeva, Bibigul; Dhaini, Batoul; Boukhlef, Samir; Moussaron, Albert; Mordon, Serge; Frochot, Céline; Collet, Charlotte; Acherar, Samir

doi:10.1016/j.ccr.2022.214702

Cited by 14 publications

(5 citation statements)

References 191 publications

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“…Radionuclide imaging is used to obtain images of organs or lesions by introducing radiopharmaceuticals to the body and measuring differences in the uptake of radiopharmaceuticals inside and outside organs or between healthy tissues and cancerous lesions. 536 Commonly used imaging instruments and equipment, include gamma cameras and emission-computed tomography, which are categorized as positron-type PECT and single-photon-type SPECT and static and dynamic imaging depending on how they were developed. 537 The deep tissue penetration ensures that RI not only shows morphological changes of bone lesions but also indicates the pathological and physiological states and functions of organs.…”

Section: In Vitro and In Vivomentioning

confidence: 99%

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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Advances in nanotechnology and nanomaterials have attracted considerable interest and play key roles in scientific innovations in diverse fields. In particular, increased attention has been focused on carbon-based nanomaterials exhibiting diverse extended structures and unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, carbon nanodiamonds, and carbon dots, possess excellent bioaffinities and superior fluorescence properties that make these structures suitable for application to environmental and biological sensing, imaging, and therapeutics. This review provides a systematic overview of the classification and structural properties, design principles and preparation methods, and optical properties and sensing applications of zero-dimensional carbon nanomaterials. Recent interesting breakthroughs in the sensitive and selective sensing and imaging of heavy metal pollutants, hazardous substances, and bioactive molecules as well as applications in information encryption, super-resolution and photoacoustic imaging, and phototherapy and nanomedicine delivery are the main focus of this review. Finally, future challenges and prospects of these materials are highlighted and envisaged. This review presents a comprehensive basis and directions for designing, developing, and applying fascinating fluorescent sensors fabricated based on zero-dimensional carbon nanomaterials for specific requirements in numerous research fields.

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Section: In Vitro and In Vivomentioning

confidence: 99%

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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“…Since EOC cells have a high expression of the folate receptor (FR) (even after NACT [4,5]), while cells in healthy tissues have almost no expression [6], FR-targeted positron emission tomography (PET) imaging seems opportune. Many folate-based radiotracers have been studied for diagnostic and therapeutic purposes [7] with great preclinical results in FR-positive tumors [8]. The FR-targeting fluorine-18 labelled radiotracer [ 18 F]fluoro-polyethylene glycol(PEG)-folate [9] has shown promising results in the first in-human clinical studies evaluating its kinetic properties and performance in imaging of arthritic joints [10,11].…”

Section: Introductionmentioning

confidence: 99%

Challenges in Pharmacokinetic Modelling of [18F]fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer Patients

Ruytenberg,

Ciggaar,

Peters

et al. 2024

Mol Imaging Biol

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Purpose To describe the pharmacokinetic properties of the [18F]fluoro-polyethylene glycol(PEG)-folate radiotracer in PET/CT imaging of patients with advanced stage epithelial ovarian cancer (EOC). Procedures In five patients with advanced EOC (FIGO stage IIIB/IIIC, Fédération Internationale de Gynécologie et d’Obstétrique), a 90-min dynamic PET acquisition of the pelvis was performed directly after i.v. administration of 185 MBq [18F]fluoro-PEG6-folate. Arterial blood samples collected at nineteen timepoints were used to determine the plasma input function. A static volume of interest (VOI) for included tumor lesions was drawn manually on the PET images. Modelling was performed using PMOD software. Three different models (a 1-tissue compartment model (1T2k) and two 2-tissue compartment models, irreversible (2T3k) and reversible (2T4k)) were compared in goodness of fit with the time activity curves by means of the Akaike information criterion. Results The pharmacokinetic analysis in the pelvic area has proven to be much more challenging than expected. Only four out of 22 tumor lesions in five patients were considered suitable to perform modelling on. The remaining tumor lesions were inapt due to either low tracer uptake, small size, proximity to other [18F]fluoro-PEG6-folate -avid structures and/or displacement by abdominal organ motion in the dynamic scan. Data from the four analyzed tumor lesions suggest that the irreversible 2T3k may best describe the pharmacokinetics. All 22 lesions were immunohistochemically stained positive for the folate receptor alpha (FRα) after resection. Conclusion Performing pharmacokinetic analysis in the abdominal pelvic region is very challenging. This brief article describes the challenges and pitfalls in pharmacokinetic analysis of a tracer with high physiological accumulation in the intestines, in case of lesions of limited size in the abdominal pelvic area.

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“…Therefore, it could be used as an important cancer biomarker and its level could be used to predict cancer stages [14,15]. FRs have been detected in tissue samples using different techniques, such as surface enhanced Raman spectroscopy (SERS) [16], proteomics assays [17], fluorescence imaging [18,19], and positron emission tomography (PET) [20,21]. However, these techniques are tedious, costly, time consuming, pose a risk to human health due to toxic radioligands, and have low sensitivity, such as FA-fluorescein isothiocyanate dye, which has a short systemic circulation time, and therefore does not target tumors efficiently [22].…”

Section: Introductionmentioning

confidence: 99%

Impedimetric Detection of Cancer Markers Based on Nanofiber Copolymers

Elnagar,

Elgiddawy,

El Rouby

et al. 2024

Biosensors

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The sensitive determination of folate receptors (FRs) in the early stages of cancer is of great significance for controlling the progression of cancerous cells. Many folic acid (FA)-based electrochemical biosensors have been utilized to detect FRs with promising performances, but most were complicated, non-reproducible, non-biocompatible, and time and cost consuming. Here, we developed an environmentally friendly and sensitive biosensor for FR detection. We proposed an electrochemical impedimetric biosensor formed by nanofibers (NFs) of bio-copolymers prepared by electrospinning. The biosensor combines the advantages of bio-friendly polymers, such as sodium alginate (SA) and polyethylene oxide (PEO) as an antifouling polymer, with FA as a biorecognition element. The NF nanocomposites were characterized using various techniques, including SEM, FTIR, zeta potential (ZP), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). We evaluated the performance of the NF biosensor using EIS and demonstrated FR detection in plasma with a limit of detection of 3 pM. Furthermore, the biosensor showed high selectivity, reliability, and good stability when stored for two months. This biosensor was constructed from ‘green credentials’ holding polymers that are highly needed in the new paradigm shift in the medical industry.

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Folate-based radiotracers for nuclear imaging and radionuclide therapy

Cited by 14 publications

References 191 publications

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Challenges in Pharmacokinetic Modelling of [18F]fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer Patients

Impedimetric Detection of Cancer Markers Based on Nanofiber Copolymers

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