Folate-decorated hydrophilic three-arm star-block terpolymer as a novel nanovehicle for targeted co-delivery of doxorubicin and Bcl-2 siRNA in breast cancer therapy

Qian, Junmin; Xu, Minghui; Suo, Aili; Xu, Weiqing; Liu, Ting; Li, Xuefeng; Yao, Yu; Wang, Hongjie

doi:10.1016/j.actbio.2014.12.018

Cited by 66 publications

(38 citation statements)

References 54 publications

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“…The PGAH core can conjugate DOX via hydrazine linkages and the inner shell of PDMAPMA allows the complexation of siRNA against Bcl-2 through electrostatic interaction, resulting in a “two-in-one” micelleplex nanocarrier. The cells studies shows that this micelleplex nanocarrier can effectively deliver Bcl-2 siRNA and DOX into the same cancer cells and induce high toxicity in a synergistic fashion 144 . In a latest studies by He et al show that they have structured a new structure based on cisplatin prodrug and self-assembled nanoscale coordination polymers.…”

Section: Use Peg-based Amphiphilic Nanostructures To Overcome Chemmentioning

confidence: 99%

Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance

Chen

Yang

Tuguntaev

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

106

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Multidrug resistance is one of the biggest obstacles in the treatment of cancer. Several factors involves in drug resistance including enhanced repair mechanisms of drug induced DNA damage, lowered tumor extracellular pH, alteration of cell cycle check points, blockage of apoptosis pathway, poor tumor vasculature and over expression of drug efflux pumps. Recent research studies highlight that tumor microenvironment plays a predominant role in tumor cell proliferation and metastasis. Hence, targeting the tumor microenvironment provides a novel strategy for the evolution of cancer nanomedicine. The blooming knowledge about the tumor microenvironment merging with the design of PEG-based amphiphilic nanoparticles can provide an effective and promising platform to address the multidrug resistant tumor cells. This review describes the characteristic features of tumor microenvironment and their targeting mechanisms with the aid of PEG-based amphiphilic nanoparticles for the development of newer drug delivery systems to overcome multidrug resistance in cancer cells.

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Section: Use Peg-based Amphiphilic Nanostructures To Overcome Chemmentioning

confidence: 99%

Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance

Chen

Yang

Tuguntaev

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

106

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“…For example, RGD-based peptide combinations [26,114,115] (Entries 1 and 2, or dual-targeted formulations employing antibodies have been developed (Entries 8-10, Table 5) [116][117][118]. Albeit some antibody-based dual-targeting nanodevices involving angiogenesis (vascular-to-cellular) or membrane-to-nucleus are interesting, there are relevant issues that remain unsolved: the unknown immunogenic effect and an undemonstrated specificity towards the desired target cell.…”

Section: Expert Opinionmentioning

confidence: 99%

Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer

Castillo

Colilla

Vallet‐Regí

2016

Expert Opinion on Drug Delivery

162

105

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Nanocarriers have emerged as a powerful alternative for cancer therapy. Indeed, they are promising candidates to tackle the acquired resistance of surviving cells against antiproliferative drugs - the so-called multidrug resistance (MDR) phenomenon - which has arisen as one of the major clinical issues of chemotherapy. Among nanocarriers, this review focuses on the recent approaches based on tailored mesoporous silica nanoparticles (MSNs) that could overcome this problem. Areas covered: Herein we summarize the current efforts developed to provide MSN-based nanosystems of enhanced dual therapeutic action against diseased cells. This can be accomplished by three main approaches: i) increasing nanosystems' killing capability towards particular cells by enhancing both recognition and specificity; ii) increasing the apoptotic effect throughout co-delivery of several drugs; or iii) combining drug delivery with apoptosis induced by physical methods. Expert opinion: The development of multifunctional nanosystems able to exert the optimal therapeutic action through the minimal administration constitutes a major challenge in nanomedicine. Recent developments in advanced MSN-based platforms for drug delivery represent promising avenues in the management of MDR associated with cancer therapy. All strategies discussed in this manuscript demonstrate improvements against difficult-to-treat tumors.

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“…In a more recent work, Qian et al [52] reported the synthesis of a folate-decorated 3-arm starblock terpolymer of the [poly(γ-hydrazide-L-glutamic acid)-b-(poly(N,N-dimethylaminopropyl DOX-loaded PMLG-b-PLGA and PGLG-b-PLGA micelles were prepared by a dialysis technique by mixing PMLG-b-PLGA or PGLG-b-PLGA and DOX·HCl in PBS at pH 7.4. PBS was removed by dialysis against deionized water.…”

Section: Polypeptide-based Micelles Bearing a Surface Ligandmentioning

confidence: 99%

“…In a more recent work, Qian et al [52] reported the synthesis of a folate-decorated 3-arm star-block terpolymer of the [poly(γ-hydrazide-L-glutamic acid)-b-(poly(N,N-dimethylaminopropyl methacrylamide)-g-poly(ethylene glycol/folic acid))] 3 ([PGAH-b-(PDMAPMA-g-FA/PEG)] 3 ) type as a novel nanocarrier for the targeted co-delivery of DOX and Bcl-2 siRNA to breast tumor tissue. FA/PEG is PEG end-functionalized by folic acid.…”

Section: Polypeptide-based Micelles Bearing a Surface Ligandmentioning

confidence: 99%

“…The comb copolymers alkyne-PAMA 12 -g-PLGA 13 , alkyne-PAMA 14 -g-PLGA 12 , alkyne-PAMA 16 -g-PLGA 12 , alkyne-PAMA 16 -g-PLGA 28 , alkyne-PAMA 16 -g-PLGA 52 , all assembled into micelles, with the exception of alkyne-PAMA 16 -g-PLGA 12 which formed vesicles in PBS at pH 7.4. Self-assembly of the alkyne-PAMA-g-PLGA comb copolymers into micellar or vesicular nanoparticles with hydrodynamic radii (Rh) values between 41.9 and 268 nm, depending on the copolymer composition and pH values (pH 6.8, 7.4, and 8.0), confirmed that nanoparticle stability depends on the molecular weight of both the PAMA backbone as well as the PLGA side chain.…”

Section: Ph-responsive Micellesmentioning

confidence: 99%

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Micelles Formed by Polypeptide Containing Polymers Synthesized Via N-Carboxy Anhydrides and Their Application for Cancer Treatment

et al. 2017

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Abstract:The development of multifunctional polymeric materials for biological applications is mainly guided by the goal of achieving the encapsulation of pharmaceutical compounds through a self-assembly process to form nanoconstructs that control the biodistribution of the active compounds, and therefore minimize systemic side effects. Micelles are formed from amphiphilic polymers in a selective solvent. In biological applications, micelles are formed in water, and their cores are loaded with hydrophobic pharmaceutics, where they are solubilized and are usually delivered through the blood compartment. Even though a large number of polymeric materials that form nanocarrier delivery systems has been investigated, a surprisingly small subset of these technologies has demonstrated potentially curative preclinical results, and fewer have progressed towards commercialization. One of the most promising classes of polymeric materials for drug delivery applications is polypeptides, which combine the properties of the conventional polymers with the 3D structure of natural proteins, i.e., α-helices and β-sheets. In this article, the synthetic pathways followed to develop well-defined polymeric micelles based on polypeptides prepared through ring-opening polymerization (ROP) of N-carboxy anhydrides are reviewed. Among these works, we focus on studies performed on micellar delivery systems to treat cancer. The review is limited to systems presented from 2000-2017.

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Folate-decorated hydrophilic three-arm star-block terpolymer as a novel nanovehicle for targeted co-delivery of doxorubicin and Bcl-2 siRNA in breast cancer therapy

Cited by 66 publications

References 54 publications

Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance

Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance

Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer

Micelles Formed by Polypeptide Containing Polymers Synthesized Via N-Carboxy Anhydrides and Their Application for Cancer Treatment

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