Folate-decorated nanogels for targeted therapy of ovarian cancer

Nukolova, N. V.; Oberoi, Hardeep S.; Cohen, Samuel M.; Kabanov, Alexander V.; Bronich, Tatiana K.

doi:10.1016/j.biomaterials.2011.04.006

Cited by 210 publications

(139 citation statements)

References 32 publications

Supporting

Mentioning

135

Contrasting

Order By: Relevance

“…32 Other tumors overexpress the FR, and folate modification has been shown to significantly improve cellular uptake and efficacy of anticancer drugs. [33][34][35][36] Tagging folate to gene therapy vectors and immunotherapeutic agents has also been shown to improve drug delivery. 34,37,38 It is well known that other receptors, such as the transferrin and mannose receptors, expressed on brain endothelial cells can also facilitate the transport of nanoparticles across the BBB.…”

Section: Discussionmentioning

confidence: 99%

Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells

Kanmogne¹,

Singh²,

Roy³

et al. 2012

IJN

View full text Add to dashboard Cite

Despite the successes of antiretroviral therapy (ART), HIV-associated neurocognitive disorders remain prevalent in infected people. This is due, in part, to incomplete ART penetration across the blood-brain barrier (BBB) and lymph nodes and to the establishment of viral sanctuaries within the central nervous system. In efforts to improve ART delivery, our laboratories developed a macrophage-carriage system for nanoformulated crystalline ART (nanoART) (atazanavir, ritonavir, indinavir, and efavirenz). We demonstrate that nanoART transfer from mononuclear phagocytes (MP) to human brain microvascular endothelial cells (HBMEC) can be realized through cell-to-cell contacts, which can facilitate drug passage across the BBB. Coculturing of donor MP containing nanoART with recipient HBMEC facilitates intercellular particle transfer. NanoART uptake was observed in up to 52% of HBMEC with limited cytotoxicity. Folate coating of nanoART increased MP to HBMEC particle transfer by up to 77%. To translate the cell assays into relevant animal models of disease, ritonavir and atazanavir nanoformulations were injected into HIV-1-infected NOD/scid-γ c null mice reconstituted with human peripheral blood lymphocytes. Atazanavir and ritonavir levels in brains of mice treated with folate-coated nanoART were three-to four-fold higher than in mice treated with noncoated particles. This was associated with decreased viral load in the spleen and brain, and diminished brain CD11b-associated glial activation. We postulate that monocyte-macrophage transfer of nanoART to brain endothelial cells could facilitate drug entry into the brain.

show abstract

Section: Discussionmentioning

confidence: 99%

Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells

Kanmogne¹,

Singh²,

Roy³

et al. 2012

IJN

View full text Add to dashboard Cite

show abstract

“…As a result, they have an unprecedented capacity for steric stabilization and decreased nonspecific interactions. The utility of such core cross-linked (cl)-micelles for encapsulation of anticancer drugs such as cisplatin 9,13,14 and doxorubicin 15,16 has been actively pursued by our group.…”

Section: Introductionmentioning

confidence: 99%

Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice

Oberoi¹,

Nukolova²,

Laquer³

et al. 2012

IJN

View full text Add to dashboard Cite

Polymer micelles with cross-linked ionic cores are shown here to improve the therapeutic performance of the platinum-containing anticancer compound cisplatin. Biodistribution, antitumor efficacy, and toxicity of cisplatin-loaded core cross-linked micelles of poly(ethylene glycol)-b-poly(methacrylic acid) were evaluated in a mouse ovarian cancer xenograft model. Cisplatin-loaded micelles demonstrated prolonged blood circulation, increased tumor accumulation, and reduced renal exposure. Improved antitumor response relative to free drug was seen in a mouse model. Toxicity studies with cisplatin-loaded micelles indicate a significantly improved safety profile and lack of renal abnormalities typical of free cisplatin treatment. Overall, the study supports the fundamental possibility of improving the potential of platinum therapy using polymer micelle-based drug delivery.

show abstract

“…The undesirable side effects of drugs could be significantly reduced by encapsulation of them into liposomes (Chekhonin et al, 2012), micelles (Oberoi et al, 2012), polymeric nanoparticles (Wohlfart et al, 2011;Steiniger et al, 2004) and other nanoparticles (Peer et al, 2007). Nanogels -nanoscale hydrogels based on hydrophilic or amphiphilic polymeric network -are one of the promising nanocontainers for platinum-based drugs (Kabanov & Vinogradov, 2009;Nukolova et al, 2011a). They are characterized by high loading capacity, tunable internal volume and high stability.…”

Section: Introductionmentioning

confidence: 99%

Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1

et al. 2014

Self Cite

View full text Add to dashboard Cite

(2015) Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1, Drug Delivery, 22:3, 276-285, DOI: 10.3109/10717544.2013 AbstractTargeted drug delivery for brain tumor treatment is one of the important objectives in nanomedicine. Human glioblastoma is the most frequent and aggressive type of brain tumors. The preferential expression of membrane protein connexin 43 (Cx43) and brain-specific anion transporter (BSAT1) in the tumor and peritumoral area is a key component for targeted drug delivery. The purpose of this study was to design cisplatin-loaded nanogels conjugated with monoclonal antibodies to Cx43 and BSAT1 for treatment of intracranial gliomas 101/8. MRI volumetric analysis of tumor-bearing rats indicated significantly reduced tumor volume with cisplatin-loaded targeted-nanogel treatment compared to other formulations. The median survival of rats treated with targeted nanogels conjugated with specific mAbs against extracellular loops of Cx43 and BSAT1 were 27 and 26.6 days higher than that in control group, respectively. For the first time we demonstrated the efficiency of mAb-targeted cisplatin-loaded nanogels in the experimental model of glioma 101/8. This approach could facilitate the development of new drug delivery systems for the treatment of gliomas.

show abstract

Folate-decorated nanogels for targeted therapy of ovarian cancer

Cited by 210 publications

References 32 publications

Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells

Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells

Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice

Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1

Contact Info

Product

Resources

About