Folate food source, usual intake, and folate status in Korean adults

Kim, Young Nam; Cho, Youn-Ok

doi:10.4162/nrp.2018.12.1.47

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…Folate status of our study participants was within the range reported in previous studies of Korean adults. In previous studies, approximately 6% to 13% of males [ 13 , 33 , 34 ] and 0% to 12% of females [ 13 , 14 , 33 - 36 ] had serum or plasma folate concentrations < 6.8 nmol/L. Marginal folate deficiency (6.8-13.4 nmol/L) was presented in 44.4% of males and 34.4% of females among 195 Korean adults [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Folate, vitamin B12, and homocysteine status in the Korean population: data from the 2013-2015 Korea National Health and Nutrition Examination Survey

Song,

Park

2023

Epidemiol Health

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OBJECTIVES We aimed to assess the serum folate, vitamin B12, and homocysteine status in Korean adolescents and adults using national data. METHODS Blood samples were collected from participants aged ≥10 years in the Korea National Health and Nutrition Examination Survey 2013-2015. The stored serum samples were used to measure folate, vitamin B12, and homocysteine concentrations. A total of 8,016 participants were included in this analysis. Unweighted descriptive statistics and adjusted geometric means of the B vitamins and homocysteine concentrations were estimated. RESULTS Females had higher serum folate and vitamin B12 concentrations and lower serum homocysteine concentrations than males. Folate deficiency (<6.8 nmol/L) and hyperhomocysteinemia (>15 μmol/L) were found in 8.6% and 11.8% of males, respectively. Approximately 3% of males had low or marginally low vitamin B12 status (≤221 pmol/L). Folate and vitamin B12 deficiencies and hyperhomocysteinemia were found in <2% of females. Suboptimal folate status was prevalent among adolescents and young adults, while suboptimal vitamin B12 status and hyperhomocysteinemia were relatively higher in older adults. Adjusted mean homocysteine concentrations were sharply decreased from the first to second decile of serum folate in males. CONCLUSIONS In the Korean population, the proportion of males who achieved desirable folate and homocysteine concentrations were lower than those of females. Although most Koreans have adequate vitamin B12, a suboptimal folate status is common, particularly among adolescents and young adults. These findings could establish a foundation for public health initiatives aimed at improving folate levels in the Korean population.

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Section: Discussionmentioning

confidence: 99%

Folate, vitamin B12, and homocysteine status in the Korean population: data from the 2013-2015 Korea National Health and Nutrition Examination Survey

Song,

Park

2023

Epidemiol Health

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“…The Korean diet group, compared to control, was related to a decrease in glycated hemoglobin level, triglyceride level, and blood pressure [27,28]. In respect of folate intake, baechukimchi (Chinese style cabbage kimchi), rice, spinach, eggs, and laver were the major source of this micronutrient for Koreans [29].…”

Section: Discussionmentioning

confidence: 99%

High Serum Folate Concentration Is Associated with Better Lung Function in Male Chronic Obstructive Pulmonary Disease Patients Who Are Current Smokers: Analysis of Nationwide Population-Based Survey

et al. 2020

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Folate, folic acid, has a role in mitigating inflammatory reactions in the human body. This study aimed to evaluate the association of serum folate levels with lung function in chronic obstructive pulmonary disease (COPD) patients. Of the 8149 participants of the 2016 Korean National Health and Nutrition Examination Survey (KNHANES), 311 subjects (192 males and 119 females) having COPD defined by the lower fifth percentile of the reference population were selected. Pearson’s correlation coefficient was used to investigate the relationship between serum folate level and lung function measurements. The association between the serum folate level and lung function in patients with COPD was evaluated using multivariable linear regression analysis after adjustment for age, sex, height, high sensitivity C-reactive protein, total calorie intake, residence, smoking status and smoking pack–years, education, and household income. The serum folate level showed a positive correlation with the predicted percentage of forced expiratory volume in one second (FEV1%). In males, a trend for a positive correlation with serum folate level was observed in predicted FEV1%, FEV1 value, predicted percentage of forced vital capacity (FVC%), FVC value, and peak expiratory flow (PEF). No significant correlation between the serum folate level and lung function in females was observed. In the multivariable linear regression model, the serum folate level was associated with an increase in predicted FEV1%, FEV1 value, predicted FVC%, FVC value, and PEF; however, the significance was only observed in males, especially among current smokers. High serum folate level was positively associated with lung function measurements in male COPD patients who were current smokers. Further longitudinal studies are needed to elucidate the underlying mechanisms.

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“…In a population of individuals aged 50 years or more, 2.2–2.3% had a deficiency in folic acid (<3.0 ng/mL) [28]. In healthy Korean adults, about 13.3% of men and 3.2% of women showed a folate deficiency (<3.0 ng/mL) [30] but there has been a lack of research in elderly populations. Folate deficiency was observed in 0.02% (<1.5 ng/mL) and 1.8% (<3.0 ng/mL) of individuals in the KLOSCAD sample.…”

Section: Discussionmentioning

confidence: 99%

Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment

Jang

Han

Shin

et al. 2019

Psychiatry Investig

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Objective This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. Methods We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5-16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the "Korean Longitudinal Study on Cognitive Aging and Dementia. " The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables. The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis. Results The lowest quartile group of serum folate (≥1.5, ≤5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd-4th quartile group to the 1st quartile than among those for whom it did not (p=0.031).

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Folate food source, usual intake, and folate status in Korean adults

Cited by 11 publications

References 22 publications

Folate, vitamin B12, and homocysteine status in the Korean population: data from the 2013-2015 Korea National Health and Nutrition Examination Survey

Folate, vitamin B12, and homocysteine status in the Korean population: data from the 2013-2015 Korea National Health and Nutrition Examination Survey

High Serum Folate Concentration Is Associated with Better Lung Function in Male Chronic Obstructive Pulmonary Disease Patients Who Are Current Smokers: Analysis of Nationwide Population-Based Survey

Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment

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