Folate intake, Methylenetetrahydrofolate Reductase Polymorphisms in Association with the Prognosis of Esophageal Squamous Cell Carcinoma

Chen, Jing; Huang, Zhijie; Duan, Yu-Qin; Xiao, Xinrong; Zhang, Ru; Jiang, Jianqing

doi:10.7314/apjcp.2012.13.2.647

Cited by 15 publications

(37 citation statements)

References 33 publications

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“…Three studies presented results for ESCC and EAC separately [13][14][15][16] and five for ESCC only [17][18][19][20][21]. The remaining four did not differentiate histological type.…”

Section: Resultsmentioning

confidence: 97%

Impact of pre-diagnosis behavior on risk of death from esophageal cancer: a systematic review and meta-analysis

Fahey

Mallitt

Astell-Burt

et al. 2015

Cancer Causes Control

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“…Three studies presented results for ESCC and EAC separately [13][14][15][16] and five for ESCC only [17][18][19][20][21]. The remaining four did not differentiate histological type.…”

Section: Resultsmentioning

confidence: 97%

Impact of pre-diagnosis behavior on risk of death from esophageal cancer: a systematic review and meta-analysis

Fahey

Mallitt

Astell-Burt

et al. 2015

Cancer Causes Control

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“…Previous studies showed the folate intake and MTHFR C677T polymorphism was associated with the risk of several human cancer (Mayne et al, 2001;Chen et al, 2002, Jing et al, 2012. The activity of folate metabolic enzyme is involved in the methylation process of DNA, and recent experimental and epidemiologic studies show the MTHFR C677T polymorphism and folate status have a role in genomic DNA methylation (Friso et al, 2002;Wang et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism and Folate Intake in Esophageal Squamous Cell Carcinoma

Jing¹,

Huang²,

Duan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: The present case-control study was conducted to explore the association of MTHFR gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake. Methods: A total of 257 cases of esophageal squamous cell carcinoma confirmed by histopathological examination were collected. Genotyping of P16, MGMT and HMLH1 was accomplished by methylation-specific polymerase chain reaction (PCR) after sodium bisulfate modification of DNA and the MTHFR C677T genetic polymorphism was detected by PCRrestriction fragment-length polymorphism (PCR-RFLP). Results: The proportions of DNA hypermethylation in P16, MGMT and hMLH1 in cancer tissues were significantly higher than in paracancerous normal tissue. The proportion of hypermethylation in at least one gene was 88.5% in cancer tissue, and was also significantly higher than that in paracancerous normal tissue. Our finding showed individuals with homozygotes (TT) of MTHFR C677T had significant risk of DNA hypermethylation of MGMT in cancer tissues, with an OR (95% CI) of 3.15 (1.12-6.87). Similarly, patients with high intake of folate also showed a slight high risk of DNA methylation of MGMT, with OR (95% CI) of 2.03 (1.05-4.57). Conclusion: Our study found the P16, MGMT and hMLH1 demonstrate a high proportion of hypermethylation in esophageal squamous cell cancer cancer tissues, which might be used as biomarkers for cancer detection.

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“…Genotyping was conducted by TaqMan assays using the ABI Prism 7911HT Sequence Detection System (Applied Biosystems, Foster City, CA). Primer, probes, and reaction conditions were those described in our previous study (Jing et al, 2012). Briefly, a total PCR reaction volume of 10 uL contained 200 ng of genomic DNA and 20 pmol of each primer.…”

Section: Blood Samples and Dna Collectionmentioning

confidence: 99%

Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site

Chen¹,

Yuan²,

Duan³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in a Chinese population to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, and their interaction with infection by Helicobacter pylori and tumor location. A total of 767 patients with newly diagnosed gastric cancer and 775 controls were selected for this study. Genotyping of MTHFR C677T and A1298C was conducted by TaqMan assays using the ABI Prism 7911HT Sequence Detection System, and information 9719 MTHFR and folate and gastric cancer risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (4): 9718-9726 (2014) on folate intake was collected by questionnaire. Compared with the CC genotype of MTHFR C677T, the TT genotype was significantly associated with a decreased risk of gastric cancer when the analysis was adjusted for other potential risk factors. We found a marginal significantly decreased risk of gastric cancer for individuals carrying the T allele [adjusted odds ratio (OR) = 0.83; 95% confidence interval (CI) = 0.65-1.01]. We detected an inverse relationship between folate intake and risk of gastric cancer, and the adjusted ORs (95%CI) for moderate and high folate intake were 0.97 (0.74-1.25) and 0.64 (0.49-0.87), respectively. Moreover, H. pylori infection, folate intake, and location of the tumor showed a significant interaction with the MTHFR C677T polymorphism. Our study suggests a protective role of MTHFR 677TT and high folate intake against gastric cancer, and the effect of the MTHFR C677T genotype may differ by H. pylori infection, folate consumption, and tumor site.

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Folate intake, Methylenetetrahydrofolate Reductase Polymorphisms in Association with the Prognosis of Esophageal Squamous Cell Carcinoma

Cited by 15 publications

References 33 publications

Impact of pre-diagnosis behavior on risk of death from esophageal cancer: a systematic review and meta-analysis

Impact of pre-diagnosis behavior on risk of death from esophageal cancer: a systematic review and meta-analysis

Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism and Folate Intake in Esophageal Squamous Cell Carcinoma

Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site

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