Folate Levels in Patients With Small Intestinal Bacterial Overgrowth (SIBO)

Platovsky, Anna; Tokayer, Aaron

doi:10.14309/00000434-201410002-01790

Cited by 3 publications

(1 citation statement)

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“…Currently there are no published studies that assess the concentration of folic acid in blood serum among patients with different types of SIBO overgrowth. One previous study by Platovsky et al found that participants with higher folate levels had a 1.75 times greater likelihood of having SIBO than those with normal folate levels (95% CI=0.74-4.14) [46]. Other studies, such as those by Marie et al and Tauber et al only studied patients with systemic sclerosis and did not find any differences in serum folic acid between the SIBO group and the control group [39,47].…”

Section: Folic Acidmentioning

confidence: 92%

Identification of SIBO subtypes along with nutritional status and diet as key elements of SIBO therapy

Wielgosz-Grochowska,

Domański,

Drywień

2024

Preprint

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SIBO is a pathology of the small intestine and may predispose individuals to a range of nutritional deficiencies. Very little is known whether specific subtypes of SIBO, such as hydrogen-dominant (H+), methane-dominant (M+), or hydrogen/methane –dominant (H+/M+), impact nutritional status and dietary intake in SIBO patients. The aim of this study was to investigate possible correlations between biochemical parameters, dietary nutrient intake, and distinct SIBO subtypes. This observational study included 67 patients who were newly diagnosed with SIBO. Biochemical parameters and diet were studied utilizing laboratory tests and food records, respectively. The H+/M+ group was associated with low serum vitamin D (p&lt;0.001), low serum ferritin (p=0.001) and low fiber intake (p=0.001). The M+ group was correlated with high serum folic acid (p=0.002) and low intakes of fiber (p=0.001) and lactose (p=0.002). The H+ group was associated with low lactose intake (p=0.027). These results suggest that the subtype of SIBO may have varying effects on dietary intake, leading to a range of deficiencies in the body. Conversely, specific dietary patterns may predispose to the development of a SIBO subtype. The assessment of nutritional status and diet, along with diagnosis of SIBO substype, are believed to be key components of SIBO therapy.

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Section: Folic Acidmentioning

confidence: 92%

Identification of SIBO subtypes along with nutritional status and diet as key elements of SIBO therapy

Wielgosz-Grochowska,

Domański,

Drywień

2024

Preprint

View full text Add to dashboard Cite

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Identification of SIBO Subtypes along with Nutritional Status and Diet as Key Elements of SIBO Therapy

Wielgosz-Grochowska,

Domanski,

Drywień

2024

IJMS

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Small intestinal bacterial overgrowth (SIBO) is a pathology of the small intestine and may predispose individuals to various nutritional deficiencies. Little is known about whether specific subtypes of SIBO, such as the hydrogen-dominant (H+), methane-dominant (M+), or hydrogen/methane–dominant (H+/M+), impact nutritional status and dietary intake in SIBO patients. The aim of this study was to investigate possible correlations between biochemical parameters, dietary nutrient intake, and distinct SIBO subtypes. This observational study included 67 patients who were newly diagnosed with SIBO. Biochemical parameters and diet were studied utilizing laboratory tests and food records, respectively. The H+/M+ group was associated with low serum vitamin D (p < 0.001), low serum ferritin (p = 0.001) and low fiber intake (p = 0.001). The M+ group was correlated with high serum folic acid (p = 0.002) and low intakes of fiber (p = 0.001) and lactose (p = 0.002). The H+ group was associated with low lactose intake (p = 0.027). These results suggest that the subtype of SIBO may have varying effects on dietary intake, leading to a range of biochemical deficiencies. Conversely, specific dietary patterns may predispose one to the development of a SIBO subtype. The assessment of nutritional status and diet, along with the diagnosis of SIBO subtypes, are believed to be key components of SIBO therapy.

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A Comprehensive Review of the Usefulness of Prebiotics, Probiotics, and Postbiotics in the Diagnosis and Treatment of Small Intestine Bacterial Overgrowth

Martyniak,

Wójcicka,

Rogatko

et al. 2025

Microorganisms

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Small intestinal bacterial overgrowth (SIBO) is a disorder characterized by the excessive growth of bacteria in the small intestine. Bacterial overgrowth disrupts the bacterial balance and can lead to abdominal pain, weight loss, and gastrointestinal symptoms, including bloating, diarrhea, and malabsorption. SIBO is widespread in the population. There are two main methods for diagnosing SIBO: breath tests and bacterial culture. The most commonly used method is a breath test, which enables the division of SIBO into the following three types: hydrogen-dominant (H-SIBO), methane-dominant (CH4-SIBO), and hydrogen/methane-dominant (H/CH4-SIBO). This comprehensive review aims to present the current knowledge on the use of prebiotics, probiotics, and postbiotics in the context of SIBO. For this purpose, medical databases such as MEDLINE (PubMed) and Scopus were analyzed using specific keywords and their combinations. This review is based on research studies no older than 10 years old and those using only human models. In summary, clinical studies have shown that the efficacy of SIBO therapy can be increased by combining antibiotics with probiotics, especially in vulnerable patients such as children and pregnant women. The further development of diagnostic methods, such as point of care testing (POCT) and portable devices, and a better understanding of the mechanisms of biotics action are needed to treat SIBO more effectively and improve the quality of life of patients.

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Folate Levels in Patients With Small Intestinal Bacterial Overgrowth (SIBO)

Cited by 3 publications

References 0 publications

Identification of SIBO subtypes along with nutritional status and diet as key elements of SIBO therapy

Identification of SIBO subtypes along with nutritional status and diet as key elements of SIBO therapy

Identification of SIBO Subtypes along with Nutritional Status and Diet as Key Elements of SIBO Therapy

A Comprehensive Review of the Usefulness of Prebiotics, Probiotics, and Postbiotics in the Diagnosis and Treatment of Small Intestine Bacterial Overgrowth

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