Folate mediated targeted delivery of cinnamaldehyde loaded and FITC functionalized magnetic nanoparticles in breast cancer:<i>in vitro</i>,<i>in vivo</i>and pharmacokinetic studies

Shetty, Varsha; Jakhade, Alok P.; Shinde, Kavita; Chikate, Rajeev C.; Kaul-Ghanekar, Ruchika

doi:10.1039/d0nj04319b

Cited by 7 publications

(5 citation statements)

References 69 publications

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“…In addition with PLGA, other polymers such as PEG [4] and chitosan [17] were used for the delivery of cinnamon essential oil and cinnamon extract, respectively. The anti-tumor effect of Fe 3 O 4 nanoparticles coated with cinnamaldeyde and FITC was seen on the breast adenocarcinoma animal model [18]. In our study, this is the first time that cinnamon extract was encapsulated in PLGA nanoparticles coated with PVA and poloxamer188.…”

Section: Discussionmentioning

confidence: 49%

PLGA Nanoparticles Loaded with Cinnamon Extract and Coated with PVA/Poloxamer188

2023

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Section: Discussionmentioning

confidence: 49%

PLGA Nanoparticles Loaded with Cinnamon Extract and Coated with PVA/Poloxamer188

2023

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“…Cancer therapy with iron oxide nanoparticles is a promising treatment strategy 104 . Shetty et al fabricated magnetic nanoparticles functionalized with folic acid, loaded with cinnamaldehyde and, used it for active targeting of breast cancer cells 105 . Conjugation of Folic acid moieties improved cell uptake of nanoparticles in breast cancer cells with their localization in both nucleus and cytoplasm compartments.…”

Section: Folate-modified Iron Oxide Nanoparticles (Io Nanoparticles)mentioning

confidence: 99%

An updated review of folate-functionalized nanocarriers: A promising ligand in cancer

Ebrahimnejad

Taleghani

Asare-Addo

et al. 2022

Drug Discovery Today

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“…FA can be used as a targeting agent to cancer cells, since several tumor cells overexpress FA receptors. Thus, the use of FA for surface functionalization promotes cellular internalization of SPIONs [ 18 ]. In this way, the mechanism of endocytosis mediated by the folate receptor and the subcellular traffic of nanoparticles [ 19 ] could be achieved.…”

Section: Introductionmentioning

confidence: 99%

Coating of SPIONs with a Cysteine-Decorated Copolyester: A Possible Novel Nanoplatform for Enzymatic Release

et al. 2023

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Superparamagnetic iron oxide nanoparticles (SPIONs) have their use approved for the diagnosis/treatment of malignant tumors and can be metabolized by the organism. To prevent embolism caused by these nanoparticles, they need to be coated with biocompatible and non-cytotoxic materials. Here, we synthesized an unsaturated and biocompatible copolyester, poly (globalide-co-ε-caprolactone) (PGlCL), and modified it with the amino acid cysteine (Cys) via a thiol-ene reaction (PGlCLCys). The Cys-modified copolymer presented reduced crystallinity and increased hydrophilicity in comparison to PGlCL, thus being used for the coating of SPIONS (SPION@PGlCLCys). Additionally, cysteine pendant groups at the particle’s surface allowed the direct conjugation of (bio)molecules that establish specific interactions with tumor cells (MDA-MB 231). The conjugation of either folic acid (FA) or the anti-cancer drug methotrexate (MTX) was carried out directly on the amine groups of cysteine molecules present in the SPION@PGlCLCys surface (SPION@PGlCLCys_FA and SPION@PGlCLCys_MTX) by carbodiimide-mediated coupling, leading to the formation of amide bonds, with conjugation efficiencies of 62% for FA and 60% for MTX. Then, the release of MTX from the nanoparticle surface was evaluated using a protease at 37 °C in phosphate buffer pH~5.3. It was found that 45% of MTX conjugated to the SPIONs were released after 72 h. Cell viability was measured by MTT assay, and after 72 h, 25% reduction in cell viability of tumor cells was observed. Thus, after a successful conjugation and subsequent triggered release of MTX, we understand that SPION@PGlCLCys has a strong potential to be treated as a model nanoplatform for the development of treatments and diagnosis techniques (or theranostic applications) that can be less aggressive to patients.

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Folate mediated targeted delivery of cinnamaldehyde loaded and FITC functionalized magnetic nanoparticles in breast cancer:in vitro,in vivoand pharmacokinetic studies

Abstract: FiCF NPs induced apoptosis in breast cancer cells, exhibited safety, reduced tumor burden in mice due to increased pharmacological efficacy.

Cited by 7 publications

References 69 publications

PLGA Nanoparticles Loaded with Cinnamon Extract and Coated with PVA/Poloxamer188

PLGA Nanoparticles Loaded with Cinnamon Extract and Coated with PVA/Poloxamer188

An updated review of folate-functionalized nanocarriers: A promising ligand in cancer

Coating of SPIONs with a Cysteine-Decorated Copolyester: A Possible Novel Nanoplatform for Enzymatic Release

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