Folate receptor targeted chitosan and polydopamine coated mesoporous silica nanoparticles for photothermal therapy and drug delivery

Bhartiya, Prabha; Chawla, Ruchi; Dutta, Pradip Kumar

doi:10.1080/10601325.2022.2135443

Cited by 4 publications

(1 citation statement)

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“…As a photothermal agent, PDA has a strong near-infrared absorption capacity and an absorption capacity in the 808 nm near-infrared band [ 38 ]. Ferric ions were added to the MPDA preparation process to improve the infrared absorption capacity and photothermal efficiency of the obtained MPDA nanoparticles [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Delivery of Doxorubicin by Ferric Ion-Modified Mesoporous Polydopamine Nanoparticles and Anticancer Activity against HCT-116 Cells In Vitro

Guo

Ling

et al. 2023

IJMS

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In clinical cancer research, photothermal therapy is one of the most effective ways to increase sensitivity to chemotherapy. Here, we present a simple and effective method for developing a nanotherapeutic agent for chemotherapy combined with photothermal therapy. The nanotherapeutic agent mesoporous polydopamine-Fe(III)-doxorubicin-hyaluronic acid (MPDA-Fe(III)-DOX-HA) was composed of mesoporous polydopamine modified by ferric ions and loaded with the anticancer drug doxorubicin (DOX), as well as an outer layer coating of hyaluronic acid. The pore size of the mesoporous polydopamine was larger than that of the common polydopamine nanoparticles, and the particle size of MPDA-Fe(III)-DOX-HA nanoparticles was 179 ± 19 nm. With the presence of ferric ions, the heat generation effect of the MPDA-Fe(III)-DOX-HA nanoparticles in the near-infrared light at 808 nm was enhanced. In addition, the experimental findings revealed that the active targeting of hyaluronic acid to tumor cells mitigated the toxicity of DOX on normal cells. Furthermore, under 808 nm illumination, the MPDA-Fe(III)-DOX-HA nanoparticles demonstrated potent cytotoxicity to HCT-116 cells, indicating a good anti-tumor effect in vitro. Therefore, the system developed in this work merits further investigation as a potential nanotherapeutic platform for photothermal treatment of cancer.

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Section: Resultsmentioning

confidence: 99%