Folate-Related Nutrients, Genetic Polymorphisms, and Colorectal Cancer Risk: the Fukuoka Colorectal Cancer Study

Morita, Makiko; Yin, Guang; Yoshimitsu, Shin ichiro; Ohnaka, Keizo; Toyomura, Kengo; Kono, Suminori; Ueki, Takashi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Tomonori; Izutsu, Koji; Futami, Kitaroh; Maekawa, Takafumi; Yasunami, Yohichi; Takenaka, Katsuto; Ichimiya, Hitoshi; Terasaka, Reiji

doi:10.7314/apjcp.2013.14.11.6249

Cited by 24 publications

(28 citation statements)

References 47 publications

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“…B vitamins, including folate, vitamin B6, and vitamin B12, play an important role in the metabolism of coenzymes in one-carbon units, and they are also important in DNA synthesis, repair, and methylation (Ulrich, 2005). Previous studies have indicated a potential association between folate intake and other vitamins and risk of several cancers, such as oral and pharyngeal cancer, breast cancer, colorectal cancer, and esophageal cancer (Bravi et al, 2013;Liu et al, 2013;Morita et al, 2013;Sharp et al, 2013). For breast cancer, a recent metaanalysis showed high folate intake did not protect against breast cancer development (Castillo et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vitamin B12 levels were calculated, and the MTHFR C677T and A1298C and MTR A2756G polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Breast cancer cases were generally older, older at first live birth, and younger at menarche, had a higher body mass index, were smokers, had higher energy intake, and more first-degree relatives with breast cancer as well as more live births compared to controls. With respect to energy intake, we found that higher energy intake were more likely to increase the risk of breast cancer. The MTHFR 667TT genotype was associated with a moderately increased risk of breast cancer when compared with the CC genotype, and a significant odds ratio (OR; 95% confidence interval, CI) was found (OR = 1.70, 95%CI = 1.06-2.73). Individuals carrying T allele were associated with higher risk of breast cancer when compared with C allele (OR = 1.34, 95%CI = 1.06-1.70). We did not find a significant effect of the MTHFR A1298C and MTR A2756G on the risk of breast cancer. We did not find any association between folate intake and MTHFR C677T polymorphisms.In conclusion, we found that the MTHFR C667T polymorphism is associated with the risk of breast cancer, indicating that this genotype plays a role in breast cancer development.

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Section: Introductionmentioning

confidence: 99%

Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer

et al. 2014

Genet. Mol. Res.

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“…Most previous studies have assessed vitamin B2 intake only from food sources and did not take into account intake from supplemental sources . Only a few studies evaluated the associations between total vitamin B2 intake including supplements or supplemental vitamin B2 intake itself and CRC risk.…”

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confidence: 99%

“…1 Despite these mechanisms suggesting a potential role of B2 in colorectal carcinogenesis, epidemiological studies have been inconsistent. In contrast to null findings from most individual cohort studies [2][3][4][5][6][7][8] and case-control studies, [9][10][11][12][13][14][15][16][17] a recent metaanalyses found significant inverse association between vitamin B2 intake and risk of colorectal cancer (CRC) from four casecontrol studies [pooled odds ratio (OR) 5 0.78, 95% confidence interval (95% CI): 0.66-0.91 for highest vs. lowest categories of intake of vitamins B2] and from five prospective cohort studies (pooled OR 5 0.86, 95% CI: 0.76-0.97). 18,19 These suggest that limited statistical power might have been a reason for the null associations in individual studies.…”

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confidence: 99%

Vitamin B2 intake and colorectal cancer risk; results from the Nurses' Health Study and the Health Professionals Follow‐Up Study cohort

Yoon

Jung

Zhang

et al. 2016

Intl Journal of Cancer

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Vitamin B2 serves as a cofactor to enhance one-carbon metabolism, maintain mucous membranes, and has been implicated in lowering colorectal cancer (CRC) risk. However, few prospective studies have examined the association between vitamin B2 intake and CRC. In this study, we estimated the associations between vitamin B2 intake and CRC risk using the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS) cohorts. Vitamin B2 intake was measured by a validated food frequency questionnaire every 4 years. Among 100,033 women in the NHS and 44,007 men in the HPFS we documented a total of 3,037 incident CRC cases (2,093 women and 944 men) during 24–26 years of follow-up until 2010. Intakes of total (from food and supplements), dietary (from food only), and supplemental vitamin B2 were inversely related to CRC risk in age-adjusted analysis in NHS. However, the association was attenuated and no longer statistically significant in multivariate analysis (P-trend ≥0.08). The pooled multivariate relative risks (95% confidence interval) comparing individuals in the extreme quintiles of intakes were 0.93 (0.81–1.06) for total vitamin B2, 0.89 (0.61–1.28) for dietary vitamin B2 and 0.94 (0.81–1.08) for supplemental vitamin B2. These associations of total vitamin B2 intake were similar for risk of CRC with varying lag-time periods (0–4, 4–8, 8–12, or 12–16 years), for risk of CRC subtypes by tumor location, and across strata of intake of folate or alcohol. Our prospective data do not support a beneficial role of vitamin B2 intake in lowering incidence of CRC.

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“…Calcium appears to have anti-tumor activities and previous studies have indicated that dietary calcium may protect against the risk of colon cancer development or act as a confounding factor (Sesink et al, 2001;Galas et al, 2013;Morita et al, 2013). Calcium is involved in cell proliferation and differentiation and decreases colonic epithelial cell proliferation (Buset et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Parathyroid Hormone Gene rs6256 and Calcium Sensing Receptor Gene rs1801725 Variants are not Associated with Susceptibility to Colorectal Cancer in Iran

Mahmoudi¹,

Karimi²,

Arkani³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Substantial evidence from epidemiological studies has suggested that increased levels of calcium may play a protective role against colorectal cancer (CRC). Given the vital role of calcium sensing receptor (CaSR) and parathyroid hormone (PTH) in the maintenance of calcium homeostasis, we explored whether the rs1801725 (A986S) variant located in exon 7 of the CaSR gene and the rs6256 variant located in exon 3 of PTH gene might be associated with CRC risk. Materials and Methods: In this study 860 subjects including 350 cases with CRC and 510 controls were enrolled and genotyped using PCR-RFLP methods. Results: We observed no significant difference in genotype or allele frequencies between the cases with CRC and controls for both CaSR and PTH genes either before or after adjustment for confounding factors including age, BMI, sex, smoking status, and family history of CRC. Furthermore, no evidence for effect modification of any association of rs1801725 and rs6256 variants and CRC by BMI, sex, or tumor site was observed. In addition, there was no significant difference in genotype and allele frequencies between the normal weight (BMI <25 kg/m 2 ) cases and overweight/ obese (BMI ≥25 kg/m 2 ) cases for the two SNPs. Conclusions: These data indicated that the CaSR gene A986S variant is not a genetic contributor to CRC risk in the Iranian population. Furthermore, our results suggest for the first time that PTH gene variant does not affect CRC risk. Nonetheless, further studies with larger sample size are needed to validate these findings.

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Folate-Related Nutrients, Genetic Polymorphisms, and Colorectal Cancer Risk: the Fukuoka Colorectal Cancer Study

Cited by 24 publications

References 47 publications

Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer

Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer

Vitamin B2 intake and colorectal cancer risk; results from the Nurses' Health Study and the Health Professionals Follow‐Up Study cohort

Parathyroid Hormone Gene rs6256 and Calcium Sensing Receptor Gene rs1801725 Variants are not Associated with Susceptibility to Colorectal Cancer in Iran

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