In recent years, 4D printing has allowed the rapid development of new concepts of multifunctional/adaptive structures. The 4D printing technology makes it possible to generate new shapes and/or property-changing capabilities by combining smart materials, multiphysics stimuli, and additive manufacturing. Hygromorphs constitute a specific class of new smart materials where their properties and morphing capabilities are dependent on the surrounding humidity, which drives actuation. Although multiple efforts have been made to fabricate hygromorph demonstrators, a comprehensive design process to produce hygromorphs by multiple 4D printing techniques is not yet available. The broad aim of this review and concept paper is to i) highlight existing scientific and technology gaps in the field of 4D-printed hygromorphs, ii) identify tools existing in other research fields for filling those gaps, and iii) discuss a series of guidelines for tackling future challenges and opportunities to develop 4D-printed composite hygromorph materials and related manufacturing processes. Accordingly, this review describes the materials and additive manufacturing techniques used for hygromorph composite fabrication. Moreover, the relevant parameters that control actuation, the models selection and performance, the design methods and the actuation measurements for customized 4D-printed hygromorph materials, are discussed.