Folding of Nanoparticle Chains into 2D Arrays: Structural Change of DNA‐Functionalized Gold Nanoparticle Assemblies

Shiraishi, Shota; Li, Yu; Akiyama, Yoshitsugu; Wang, Guoqing; Kikitsu, Tomoka; Miyamura, Kazuo; Takarada, Tohru; Maeda, Mizuo

doi:10.1002/admi.201800189

Cited by 11 publications

(14 citation statements)

References 63 publications

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“…When the fully matched DNA duplexes were formed on the particle surfaces, the TEM observation revealed highly packed 2D AuNP assemblies (Figures e and S2). This result was consistent with our previous study employing linear AuNP assemblies . The average number of AuNPs per assembly (Figure h) was in good agreement with the value for the precursory ssDNA–AuNP assembly (Figure g).…”

Section: Resultsmentioning

confidence: 85%

“…In contrast, the particles having a single-base mismatch or a single-nucleotide overhang on the periphery of the DNA shell continue to stably disperse. In a previous study, we prepared a precursory linear chain of fully matched dsDNA–AuNPs using a long repetitive DNA strand as a template . By inducing non-cross-linking assembly between the constituent particles, the chains were folded to afford 2D arrays of AuNPs on the substrate.…”

Section: Introductionmentioning

confidence: 99%

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DNA-Programmed Bimodal 2D Assembly of Differently Sized Nanoparticles via Folding of Precursory Circular Chains

Yang

Akiyama

et al. 2020

Langmuir

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Gold nanoparticle (AuNP) assemblies in two-dimensions (2D) exhibit collective physical/chemical properties that are useful for various devices. However, technical issues still impede the efficient ordering of differently sized AuNPs on solid supports while avoiding phase separation. This paper describes a method to construct binary 2D assemblies by folding precursory circular chains composed of small and large AuNPs. The structural change is caused by a spontaneous, noncross-linking assembly of fully matched double-stranded DNA-modified AuNPs (dsDNA−AuNPs) at a high ionic strength. Since larger dsDNA− AuNPs have a lower critical coagulation concentration of the supporting electrolyte, the spontaneous assembly of large AuNPs precedes that of small AuNPs in the precursory chain during evaporation. Transmission electron microscopy reveals that alternate-type AuNP chains are folded into a binary 2D structure in a mixed mode, whereas blocktype chains are transformed into a binary 2D structure in a core−shell mode. The methodology could potentially be harnessed for the fabrication of binary AuNP arrays for various devices.

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Section: Resultsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

DNA-Programmed Bimodal 2D Assembly of Differently Sized Nanoparticles via Folding of Precursory Circular Chains

Yang

Akiyama

et al. 2020

Langmuir

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“…For AuNSs that exhibit uniform surface activity, however, it would be much more difficult, even though a multi-step method has been used to prepare bifunctional monomer to construct assemblies with ordered spatial arrangement. [56][57][58][59][60]…”

Section: Analytical Sciencesmentioning

confidence: 99%

DNA Base Pair Stacking Assembly of Anisotropic Nanoparticles for Biosensing and Ordered Assembly

Wang

Liang

et al. 2020

ANAL. SCI.

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Anisotropic gold nanoparticles have attracted great interest due to their unique physicochemical properties derived from the shape anisotropy. Manipulation of their interfacial interactions, and thereby the assembling behaviors are often requisite in their applications ranging from optical sensing and diagnosis to self-assembly. Recently, the control of interfacial force based on base pair stacking of DNA terminals have offered a new avenue to surface engineering of nanostructures. In this review, we focus on the DNA base stacking-induced assembly of anisotropic gold nanoparticles, such as nanorods and nanotriangles. The fundamental aspects of anisotropic gold nanoparticles are provided, including the mechanism of the anisotropic growth, the properties arising from the anisotropic shape, and the construction of DNA-grafted anisotropic gold nanoparticles. Then, the advanced applications of their functional assemblies in biosensing and ordered assembly are summarized, followed by a comparison with gold nanospheres. Finally, conclusions and outlooks are given with challenges and opportunities on the futuristic directions in this field.

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“…Over the past two decades, control of the nanomaterial assembly mediated by DNA strands has been widely used in both fundamental and applied research, owing to excellent programmability and selectivity. − In most cases, nanomaterials were designed to crosslink each other via the formation of a duplex between the surface-immobilized DNA strands on assembling. Maeda and co-workers demonstrated that nanoparticles densely covered with oligo-DNA strands (DNA-NPs) aggregate in aqueous salt solutions without crosslinking formation; they showed that DNA-NPs can be dispersed stably even under high-salt conditions, but the fully matched duplex formation with complementary DNA strands on the surface leads to spontaneous aggregation in a noncrosslinking manner. − Interestingly, no aggregation occurred under the same high-salt conditions when the resulting duplex terminal was a single-base mismatch or overhang sequence. − Such terminal sequence-specificity in the dispersion behavior of DNA-NPs has been used not only for analytical purposes such as the detection of genetic polymorphisms/mutations, , toxic metal ions, , and more , but also for the construction of nanomaterial assemblies with dynamic functions. − …”

Section: Introductionmentioning

confidence: 99%

Terminal Sequence-Specific Interparticle Attraction between DNA Duplex-Carrying Polystyrene Microparticles in Aqueous Salt Solution Assessed by Optical Tweezers

2021

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The dispersion behavior of DNA duplex-carrying colloidal particles in aqueous high-salt solutions shows extraordinary selectivity against the duplex terminal sequence. We investigated the interparticle force between DNA duplex-carrying polystyrene (dsDNA-PS) microparticles in aqueous salt solutions and examined their behavior in relation to the duplex terminal sequences. Force−distance (F−D) curves for a pair of dsDNA-PS particles were recorded with a dual-beam optical tweezers system with the two optically trapped particles closely approaching each other. Interestingly, only 3− 5% of the oligo-DNA strands on the dsDNA-PS particles formed a duplex with complementary DNAs, and the F−D curves showed a distinct specificity to the duplex terminal sequences in the interparticle force at a high-NaCl concentration; a clear attraction peak was observed in F−D curves only when the duplex terminal was a complementary base pair. The attractive strength reached 2.6 ± 0.5 pN at 500 mM NaCl and 4.3 ± 1.0 pN at 750 mM NaCl. By sharp contrast, no significant attraction occurred for the particles with mismatched duplex terminals even at 750 mM NaCl. Similar duplex terminal-specificity in the interparticle force was also confirmed for dsDNA-PS particles in divalent MgCl 2 solutions. Considering that the duplex terminal sequences on the dsDNA-PS particles showed only a negligible difference in their surface charges under identical salt conditions, we concluded that the interparticle attraction observed only for the dsDNA-PS particles with complementary duplex terminals is attributable to the salt-facilitated stacking interaction between the paired terminal nucleobases (i.e., blunt-end stacking) on the dsDNA-PS surfaces. Our results thus demonstrate the occurrence of a duplex terminal-specific interparticle force between dsDNA-PS particles under high-salt conditions.

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Folding of Nanoparticle Chains into 2D Arrays: Structural Change of DNA‐Functionalized Gold Nanoparticle Assemblies

Cited by 11 publications

References 63 publications

DNA-Programmed Bimodal 2D Assembly of Differently Sized Nanoparticles via Folding of Precursory Circular Chains

DNA-Programmed Bimodal 2D Assembly of Differently Sized Nanoparticles via Folding of Precursory Circular Chains

DNA Base Pair Stacking Assembly of Anisotropic Nanoparticles for Biosensing and Ordered Assembly

Terminal Sequence-Specific Interparticle Attraction between DNA Duplex-Carrying Polystyrene Microparticles in Aqueous Salt Solution Assessed by Optical Tweezers

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