Background and objective: Salinity stress is an important abiotic stress that affect adversely on crop production, so using of natural compounds to improve plant tolerance to stress is very important. Materials and methods: Two field experiments were conducted during two winter seasons of 2014/2015 and 2015/2016 at Tag El-Ezz Research Station of Agricultural Research Centre, Dakahliea Egypt. Field evaluation of the efficiency of weed-control treatments (unweeded, oxadiargyl, and two hand hoeing) and thiamine levels (0, 50, 75, and 100 mg/l) and their interactive effects on weeds, faba bean growth, yield, yield attributes, and some biochemical constitutes of seeds under salinity levels (1.37, 3.31, and 4.51 dS m −1). Results: Data revealed that number and dry weight of broad-leaved, narrow-leaved, and total weeds were significantly reduced by increasing salinity levels of soil from 1.37 to 4.51 dS m −1. In addition, the highest salinity level 4.51 dS m −1 caused the highest significant decreases in growth, yield, and yield attributes of faba bean. Meanwhile, increasing salinity level from 1.3 to 4.51 dS m −1 caused significant increases in total soluble sugar, free amino acids, and proline contents of faba bean plant. Two hand hoeing treatment achieved the highest weed depression expressed in the lowest dry matter of total weeds. Also, two hand hoeing was the most effective weed control treatment in increasing growth, yield, yield attributes, and some biochemical constitutes of faba bean seeds followed by of oxadiargyl treatment. No significant differences between application of two hand-hoeing and oxadiargyl treatment on all studied parameters. Foliar treatment of faba bean plants with thiamine different concentrations could alleviate the harmful effects of different salinity levels. Conclusion: We could conclude that foliar application of thiamine at the rate of 100 mg/l caused the highest increases in all growth and yield parameters under investigation of faba bean plant. Interaction of 100 mg/l thiamine treatment and two hand hoeing was the most effective treatments on enhancing faba bean growth, yield, and its attributes under salinity levels. Results also indicated that free amino and proline works to increase faba bean plants ability to withstand salinity stress.