Our objective was to quantify the efficacy of different plant growth regulator (PGR) substrate drenches on growth of lantana (Lantana camara) cultivars varying in growth habit. Rooted ‘Little Lucky Peach Glow’, ‘Lucky Peach’, and ‘Landmark Peach Sunrise’ lantana cuttings were individually planted into 4-inch-diameter containers filled with a commercial, soilless growing substrate. Fourteen days after planting, solutions containing 0 (control), 0.5, 1, 2, or 4 mg·L−1 ancymidol, flurprimidol, paclobutrazol, or uniconazole were applied to the surface of the growing substrate. Six weeks after applying PGR drenches, data were collected. The growth index (GI), an integrated measurement of plant size incorporating the height and widths of plants, was calculated. There was variation in the GI among the control plants, reflecting variation among cultivars within the species. In addition, we measured variation in activity among the different PGRs applied. Across the concentrations applied, ancymidol generally had the lowest activity across the four PGRs. For example, drenches containing 4 mg·L−1 ancymidol resulted in plants that were similar to plants treated with 0.5 to 1 mg·L−1 flurprimidol or uniconazole or 2 mg·L−1 paclobutrazol for ‘Lucky Peach’ lantana. Across all cultivars, flurprimidol and uniconazole had the greatest activity in suppressing plant height, width, and GI. Substrate drenches containing flurprimidol, paclobutrazol, or uniconazole are useful to control size of lantana produced in containers, though the recommended concentration depends on the active ingredient and the growth habit of cultivars being treated.