Folic acid-decorated polyamidoamine dendrimer exhibits high tumor uptake and sustained highly localized retention in solid tumors: Its utility for local siRNA delivery

Xu, Leyuan; Yeudall, W. Andrew; Yang, Hu

doi:10.1016/j.actbio.2017.04.023

Cited by 54 publications

(21 citation statements)

References 54 publications

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“…RNA‐mediated therapeutic approaches can be selectively downregulated molecular targets in signaling pathways that are responsible for cell proliferation and significantly reduced multidrug resistance in comparison to drugs (Lo et al, ). Xu, Yeudall, & Yang, () prepared FA‐PAMAM NPs for active delivery of siRNA against vascular endothelial growth factor A (siVEGFA) in head and neck squamous cell carcinomas. The VEGFA is a main regulator of angiogenesis and promotes tumor development in tumor tissues, so that its knockdown has been shown to be effective in inhibiting tumor growth.…”

Section: Polymer‐based Nps In Drug Deliverymentioning

confidence: 99%

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Narmani

Rezvani

Farhood

et al. 2019

Drug Development Research

171

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Conventional chemotherapeutic approaches in cancer therapy such as surgery, chemotherapy, and radiotherapy have several disadvantages due to their nontargeted distributions in the whole body. On the other hand, nanoparticles (NPs) based therapies are remarkably progressing to solve several limitations of conventional drug delivery systems (DDSs) including nonspecific biodistribution and targeting, poor water solubility, weak bioavailability and biodegradability, low pharmacokinetic properties, and so forth. The enhanced permeability and retention effect escape from Pglycoprotein trap in cancer cells as a passive targeting mechanism, and active targeting strategies are also other most important advantages of NPs in cancer diagnosis and therapy. Folic acid (FA) is one of the biologic molecules which has been targeted overexpressed-folic acid receptor (FR) on the surface of cancer cells. Therefore, conjugation of FA to NPs most easily enhances the FR-mediated targeting delivery of therapeutic agents. Here, the recent works in FA which have been decorated NPs-based DDSs are discussed and cancer therapy potency of these NPs in clinical trials are presented. K E Y W O R D Scancer diagnosis and therapy, folic acid, nanoparticles, nanotechnology, targeted drug delivery

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Section: Polymer‐based Nps In Drug Deliverymentioning

confidence: 99%

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Narmani

Rezvani

Farhood

et al. 2019

Drug Development Research

171

View full text Add to dashboard Cite

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“…A promising strategy for improved anti-tumour effect was achieved by co-delivering of small interfering RNA with cisplatin, doxorubicin and ursolic acid in folate-targeted liposomes [ 94 , 95 , 96 ]. In addition, dendrimers made from cationic polymers can be considered as carriers appropriate for gene delivery, e.g., siRNA [ 97 , 98 ], because they can provide good protective properties against rapid enzyme degradation and effective gene transport to intracellular space. The problem of poor cationic polymer safety was overcome by the idea of a modification of terminal amines of the dendrimers with gold nanoparticles and conjugation of folic acid.…”

Section: Folic Acid—targeted Nanoparticlesmentioning

confidence: 99%

Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

et al. 2021

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Cancer is one of the major causes of death worldwide and its treatment remains very challenging. The effectiveness of cancer therapy significantly depends upon tumour-specific delivery of the drug. Nanoparticle drug delivery systems have been developed to avoid the side effects of the conventional chemotherapy. However, according to the most recent recommendations, future nanomedicine should be focused mainly on active targeting of nanocarriers based on ligand-receptor recognition, which may show better efficacy than passive targeting in human cancer therapy. Nevertheless, the efficacy of single-ligand nanomedicines is still limited due to the complexity of the tumour microenvironment. Thus, the NPs are improved toward an additional functionality, e.g., pH-sensitivity (advanced single-targeted NPs). Moreover, dual-targeted nanoparticles which contain two different types of targeting agents on the same drug delivery system are developed. The advanced single-targeted NPs and dual-targeted nanocarriers present superior properties related to cell selectivity, cellular uptake and cytotoxicity toward cancer cells than conventional drug, non-targeted systems and single-targeted systems without additional functionality. Folic acid and biotin are used as targeting ligands for cancer chemotherapy, since they are available, inexpensive, nontoxic, nonimmunogenic and easy to modify. These ligands are used in both, single- and dual-targeted systems although the latter are still a novel approach. This review presents the recent achievements in the development of single- or dual-targeted nanoparticles for anticancer drug delivery.

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“…This phenomenon disappeared after the application of the double dose, indicating that the double dose may have a sustained anti-tumor effect. In short, G4-FA is a safe nanoplatform that can specifically deliver siRNA to locally target the treatment of head and neck cancer (Xu et al, 2017).…”

Section: Dendrimersmentioning

confidence: 99%

Research Progress and Prospect of Nanoplatforms for Treatment of Oral Cancer

Zhao

et al. 2020

Front. Pharmacol.

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Oral cancers refer to malignant tumors associated with high morbidity and mortality, and oral squamous cell carcinoma accounts for the majority of cases. It is an important part of head and neck, and oral cancer is one of the six most common cancers in the world. At present, the traditional treatment methods for oral cancer include surgery, radiation therapy, and chemotherapy. However, these methods have many disadvantages. In recent years, nanomedicine, the delivery of drugs through nanoplatforms for the treatment of cancer, has become a promising substitutive therapy. The use of nanoplatforms can reduce the degradation of the drug in the body and accurately deliver it to the tumor site. This minimizes the distribution of the drug to other organs, thereby reducing its toxicity and allowing higher drug concentration at the tumor site. This review introduces polymer nanoparticles, lipid-based nanoparticles, metal nanoparticles, hydrogels, exosomes, and dendrimers for the treatment of oral cancer, and discusses how these nanoplatforms play an anti-cancer effect. Finally, the review gives a slight outlook on the future prospects of nanoplatforms for oral cancer treatment.

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Folic acid-decorated polyamidoamine dendrimer exhibits high tumor uptake and sustained highly localized retention in solid tumors: Its utility for local siRNA delivery

Cited by 54 publications

References 54 publications

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

Research Progress and Prospect of Nanoplatforms for Treatment of Oral Cancer

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