Folic acid deficiency and neutrophil dysfunction

Youinou, Pierre; Garré, M; Ménez, J. F.; Boles, J.-M.; Morin, Jean Francois; Pennec, Y; Miossec, Pierre; Morin, P; Menn, G. Le

doi:10.1016/0002-9343(82)90406-5

Cited by 36 publications

(12 citation statements)

References 18 publications

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“…We have previously reported that folic acid deficiency can reduce to a significant degree bacterial engulfment and PMN bactericidal ability. 23 In this study, however, there was no difference in the folic acid levels between the groups of patients, and phagocytosis was found to be normal.…”

Section: Discussioncontrasting

confidence: 59%

Drug induced impairment of polymorphonuclear cell bactericidal ability in rheumatoid arthritis.

Youinou¹,

Goff²

1987

Annals of the Rheumatic Diseases

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SUMMARY Thirty three patients with rheumatoid arthritis (RA) treated only with non-steroidal anti-inflammatory drugs were divided into two groups according to the drug received (group A: diclofenac, group B: indomethacin or ketoprofen), and their polymorphonuclear (PMN) cell functions were investigated. We found that bactericidal ability was the only function significantly impaired in group A as compared with group B patients and normal controls. This modification correlated well with the reduction of control PMN bactericidal ability when this test was carried out in patient plasma. These differences between drug effects might explain some of the discrepancies between reports of PMN cell functions in RA.

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Section: Discussioncontrasting

confidence: 59%

Drug induced impairment of polymorphonuclear cell bactericidal ability in rheumatoid arthritis.

Youinou¹,

Goff²

1987

Annals of the Rheumatic Diseases

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“…Fish fed FA‐free diets were not able to maintain leucocyte production after stress. Impaired synthesis and function of white cells under FA deficiency have already been described by Youinou, Garre, Menez, Boles, Morin, Pennec, Miossec, Morin and Le Menn (1982) in humans. The absence of supplementation also determined the highest significant percentage of neutrophils (neutrophilia) in the pre‐stress phase compared with other treatments.…”

Section: Resultsmentioning

confidence: 87%

Haematological response and growth performance of Nile tilapia (Oreochromis niloticusL.) fed diets containing folic acid

Barros

Ranzani-Paiva

Pezzato³

et al. 2009

Aquaculture Research

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Haematological response and growth performance over 150 days, and resistance to a low‐temperature stress of Nile tilapia fed diets with increasing folic acid (FA) levels were evaluated. The experiment was conducted in a completely randomized design with eight FA levels (0.0, 0.5, 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 mg kg−1 feed) supplemented in purified diets (32.0% CP and 13 398 kj DE kg−1). One hundred and ninety‐two fingerlings were randomly assigned to 32 net cages distributed in eight 1000 L aquaria with a physical and biological filter and a temperature control system (26.0 ± 1.0 °C). For cold‐induced stress, fish were transferred to 24 30 L‐aquaria with individual biofilters and aeration. The water temperature was gradually reduced until it reached 13 °C. Haematological parameters evaluated before and after cold stress were total erythrocytes and leucocytes count, differential leucocyte, haemoglobin, haematocrit, total plasmatic protein and haematometric indices. Growth performance parameters were mean weight gain, feed conversion ratio and survival. Dietary FA supplementation did not influence erythropoiesis under normal temperature conditions; cold stress impaired erythropoiesis, causing hypochromic microcytic anaemia and leucopoiesis, and also neutrophilia. Growth performance is influenced by folate and supplementation between 0.5 and 1.0 mg FA kg−1 diet, which makes up for nutritional demands, guaranteeing production and health under appropriate temperature conditions.

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“…However, dietary supplementation of vitamin B enhanced milk yield by 0.86 kg/day, milk fat yield by 0.07 kg/day, and milk protein yield by 0.06 kg/day, as well as decreased somatic cell count (SCC) from 611 × 1,000/ml to 349 × 1,000/ml (Sacadura, Robinson, Evans, & Lordelo, ) and ketosis prevalence from 36% to 20% (Havlin, Robinson, & Garrett, ) in early lactating cows. The beneficial effect seemed result from a better metabolic adaptation that rumen‐protected folic acid supplementation in dairy cow diets reduced blood NEFA by 4.6% and BHB by 3.0% (Li et al., ), and improved immune function that vitamin B 12 and folic acid could enhance neutrophil phagocytic ability (Kaplan & Basford, ; Youinou et al., ). In addition, vitamin B 6 , and B 12 and folate are involved in the biosynthesis of nucleic acid and protein by providing one‐carbon units, thus logically related to immune function, as antibodies and cytokines build up from amino acids.…”

Section: Introductionmentioning

confidence: 99%

Effects of an immunomodulatory feed additive on body weight, production parameters, blood metabolites, and health in multiparous transition Holstein cows

Alugongo

Xiao

et al. 2018

Animal Science Journal

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The study investigated the impact of feeding OmniGen-AF â (OG; Phibro Animal Health, Quincy, IL) from dry-off to week 4 of lactation at two doses on production performance and metabolic adaptation of multiparous Holstein cows. Forty-eight cows were blocked and assigned randomly to three treatments: OG was fed at 0 g/ head/day (CON), 60 g/head/day (OG60), or 90 g/head/day (OG90). No difference was observed in dry matter intake (DMI) throughout the experiment, whereas feeding OG tended to decrease the percentage body weight change (PWC) on week 2.Although colostrum yield was not affected by treatment, colostrum IgG production of OG90 tended to be higher than that of CON. OG supplementation did not affect overall milking performance but decreased milk SCC during the first 4 weeks of lactation. In prepartum, OG supplementation decreased the concentrations of serum albumin and calcium, and increased serum globulin. OG supplementation tended to increase serum total protein, globulin, and calcium contents postpartum. Furthermore, reduced incidence of mastitis and udder edema were observed. In conclusion, supplementing cows with OG from dry-off period reduces or modulates the inflammation responses associated with parturition, potentially resulting in improved postpartum health, while feeding OG more than 60 g/head/day did not warrant further benefits. K E Y W O R D S immunity, inflammation, OmniGen-AF, transition cow 1 | INTRODUCTION The transition period, 3 weeks before to 3 weeks after parturition, represents a window of the highest risk of metabolic disorders (fatty liver and ketosis) and infections (mastitis and metritis) throughout the entire lactation cycle (Drackley, 1999). Energy deficiency in early lactation, particularly in high-producing herd, is the biggest metabolic challenge (Ospina, Nydam, Stokol, & Overton, 2010) that drives lipolysis, which, if uncontrolled, leads to ketosis, fatty liver disease and increase the risk of other metabolic disorders and infections. Meanwhile incompetent immune function during transition period imposes further threats to the health and wellbeing of dairy herds. Dietary factors that function to modulate immunocompetence and metabolic adaptation during transition period have been of great interest in both academia and dairy industry in the last decade.Owing to rumen bacterial, synthesis vitamin B was not conventionally considered to be deficient in ruminants. However, dietary supplementation of vitamin B enhanced milk yield by 0.86 kg/day, milk fat yield by 0.07 kg/day, and milk protein yield by 0.06 kg/day, as

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Folic acid deficiency and neutrophil dysfunction

Cited by 36 publications

References 18 publications

Drug induced impairment of polymorphonuclear cell bactericidal ability in rheumatoid arthritis.

Drug induced impairment of polymorphonuclear cell bactericidal ability in rheumatoid arthritis.

Haematological response and growth performance of Nile tilapia (Oreochromis niloticusL.) fed diets containing folic acid

Effects of an immunomodulatory feed additive on body weight, production parameters, blood metabolites, and health in multiparous transition Holstein cows

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