Folic acid deficiency in pregnancy

Kitay, David Z.

doi:10.1016/0002-9378(69)90705-4

Cited by 32 publications

(18 citation statements)

References 162 publications

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“…This indicates that at least part of the rise in TIBC seen in pregnancy is hormonal in origin. Rises in TIBC which accompany iron deficiency during pregnancy are much greater than those seen in the nonpregnant state (Kitay and Harbort, 1975).…”

Section: Ironmentioning

confidence: 82%

“…A rise is seen near term as red blood cell production increases. Total iron binding capacity (TIBC) normally rises 15% in iron-sufficient pregnant women (Kitay and Harbort, 1975). A rise in TIBC has also been reported in women taking oral contraceptives (Mardell et al, 1969).…”

Section: Ironmentioning

confidence: 99%

“…Some studies indicate a decrease in mean birth weight at term in infants of women with iron deficiency (Chisholm, 1966;Whalley et al, 1969), while others report no such correlation (Kitay and Harbort, 1975). An increase in the incidence of prematurity has been reported in iron deficiency (Scott, 1962), but no significant evidence exists linking iron deficiency with congenital anomalies.…”

Section: Ironmentioning

confidence: 99%

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Nutrition and Pregnancy

Rosso

Cramoy

1979

Nutrition

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Section: Ironmentioning

confidence: 82%

Section: Ironmentioning

confidence: 99%

Section: Ironmentioning

confidence: 99%

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Nutrition and Pregnancy

Rosso

Cramoy

1979

Nutrition

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“…However, CAT activity is important during enhanced rates of cellular hydrogen peroxide production (1 5), and in vivo hyperoxia studies have shown an increase in lung CAT activity (8,28). While anticipated iron deficiency in human pregnancy may be countered by routine use of iron supplements in clinical practice (16), a prematurely born infant may rapidly deplete limited iron reserves (27) at a time when high oxygen concentrations are administered for pulmonary immaturity. We speculate that any resultant loss of CAT activity could enhance oxygen toxicity, and that this may be reversible with iron supplements.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Antioxidant Enzyme Maturation in the Fetal and Neonatal Rat. II. The Influence of Maternal Iron Supplements upon Fetal Lung Catalase Activity

Tanswell

1984

Pediatr Res

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SummaryIt was obsegved that the lung catalase activity of premature (day 21 of gestation; term = 22 days) rat pups is affected by maternal iron intake. Pups from control dams receiving Purina Lab Chow and water ad libitum have only 50% of the lung catalase activity of pups from dams who received 1 mg/kg parenteral iron dextran daily from day 7 to day 20 of gestation. Other oxygen-protective enzymes, copper-zinc and manganese superoxide dismutase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase, were unaffected by maternal iron supplements. AbbreviationsCuZn SOD, copper zinc superoxide dismutase CAT, catalase G-6-PD, glucose-6-phosphate dehydrogenase GPx, glutathione peroxidase Mn SOD, manganese superoxide dismutase HBSS, Hanks' balanced salt solution Undernutrition is reported to enhance pulmonary oxygen toxicity (10). One potential contributing factor is a loss of metalloprotein antioxidant enzymes activities upon metal depletion. This has been reported with copper (4) for CuZn SOD, with manganese (6) for Mn SOD, with iron and selenium (18) for GPx, and with iron (20) for CAT.We have previously reported that the specific activity of lung catalase of gravid female rats fed Purina Lab Chow ad libitum declined with gestation (13). The fetuses of these animals demonstrated gestation-dependent increases in specific activity of CuZn SOD, Mn SOD, GPx, and G-6-PD in lung between day 18 and day 22 (term) of gestation (24). The specific activity of fetal lung CAT, however, increased between days 18 and 20 of gestation, but showed no significant increase between day 20 and term (24). Since the fall in maternal lung CAT activity towards the end of gestation was reversed by parenteral iron supplements, it is possible that the blunted increase in fetal lung catalase reflected limited iron transport across the placenta.In this report, we examine the effect of maternal iron supplementation on fetal lung growth, and on the specific activity of oxygen-protective enzymes of fetal rats sacrificed prematurely on day 2 1 of gestation. Reported values have been corrected for Received June 13, 1983;accepted February 7, 1984 enzyme activity contributed by contaminating blood by a modification of the method described by Cross et al. (5), using homologous blood supplements. MATERIALS AND METHODSFemale Sprague-Dawley white rats of 275-300 g (Charles River Inc., St. Constant, Quebec) were mated with male hooded rats and delivered to our animal quarters the following day. From day 7 to day 20 of gestation, the gravid rats were injected intramuscularly with either 1 mg/kg/day of iron dextran in isotonic saline or isotonic saline alone, or received no injections. On day 21 of gestation (term = 22 days), the animals were sacrificed by excess chloroform anesthesia; the fetuses were decapitated in utero to prevent respiration and immediately removed from the uterus. Each fetus was weighed and the carcasses were placed in HBSS at 4°C. The chest cage was opened from diaphragm to neck; then the heart and lungs were removed en bloc and...

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“…It has been associated with a number of reproductive casualties which remain contro versial (22,32). Studies that have suggested these relationships, as well as those that have attempted to refute them, differ markedly in design and criteria for evaluation of folate status.…”

mentioning

confidence: 99%

Effect of Folic Acid Supplementation on Pregnancy in the Squirrel Monkey (Saimiri sciureus)

Rasmussen

Thenen

Hayes³

1980

J Med Primatol

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Supplementation of squirrel monkeys with folic acid improved hematologic and folate status, maternal weight gain during pregnancy, and infant birth weight. Thus the folate content in the stock diet (1.4 ug/g) did not meet the requirement for pregnancy. Low plasma vitamin B,2 values suggest that vitamin B(12) in the stock diet (22 ng/g) also was not adequate. Changes with folic acid supplementation are similar to those for human subjects, indicating that the squirrel monkey is an appropriate model for folic acid deficiency in pregnancy in man.

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Folic acid deficiency in pregnancy

Cited by 32 publications

References 162 publications

Nutrition and Pregnancy

Nutrition and Pregnancy

Pulmonary Antioxidant Enzyme Maturation in the Fetal and Neonatal Rat. II. The Influence of Maternal Iron Supplements upon Fetal Lung Catalase Activity

Effect of Folic Acid Supplementation on Pregnancy in the Squirrel Monkey (Saimiri sciureus)

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