Folic acid incorporated nitrogen‐doped carbon dots as a turn‐on fluorescence probe for homocysteine detection

Madanan, Anju S; Aswathy, Ajayakumar; Varghese, Susan; Abraham, Merin K; S, Lekshmi R; Shkhair, Ali Ibrahim; Lekha, G.M.; Syamchand, Sasidharanpillai S.; George, Sony

doi:10.1002/bio.4411

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…Optical sensors provide significant benefits such as economical cost, rapid response, high accuracy, and portable detection. 22 This means they can be used in many fields, including disease diagnosis, 23,24 food safety, 25 healthcare, 26,27 agriculture, 28 Recently, various fluorescent materials (e.g., conjugate polymers, 32,33 rare-earth-doped upconversion nanoparticles, 34,35 quantum dots, 36 carbon dots, 37,38 metal−organic frameworks, 39 and metal nanoclusters) 28,40−43 have been used to develop luminescent sensors. The use of fluorescent metal-NCs in biochemical analysis has garnered significant interest among researchers.…”

Section: Introductionmentioning

confidence: 99%

“…Optical sensors provide significant benefits such as economical cost, rapid response, high accuracy, and portable detection . This means they can be used in many fields, including disease diagnosis, , food safety, healthcare, , agriculture, and environmental protection. − The fluorescent sensors show signal output and high sensitivity; therefore, academics and researchers find it attractive. Recently, various fluorescent materials (e.g., conjugate polymers, , rare-earth-doped upconversion nanoparticles, , quantum dots, carbon dots, , metal–organic frameworks, and metal nanoclusters) ,− have been used to develop luminescent sensors.…”

Section: Introductionmentioning

confidence: 99%

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Mo(IV) Ion-Modulated BSA-Protected Gold Nanocluster Probe for Fluorescence Turn-On Detection of Trimethylamine N-Oxide (TMAO)

Shkhair,

Madanan,

Varghese

et al. 2024

ACS Appl. Bio Mater.

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Trimethylamine N-oxide (TMAO), a molecule produced by the microbiota, has been associated with human health and illness. Its early discovery in body fluids may affect our understanding of the pathophysiology and treatment of many illnesses. Therefore, our knowledge of the pathophysiology and diagnostics of disorders associated with TMAO might be enhanced by the creation of dependable and fast methods for TMAO detection. Therefore, we developed a fluorescent probe for detecting TMAO utilizing an on−off−on strategy. Bovine serum albumin (BSA)@AuNCs luminescence is effectively quenched by Mo 4+ because BSA@AuNCs and Mo 4+ have a strong binding relationship. Mo 4+ ions can substantially decrease the emission intensity of gold nanoclusters by establishing a BSA@AuNCs-Mo system. Then, the luminescence of BSA@AuNCs was restored due to the interaction between Mo 4+ and TMAO. A significant linear relationship was seen between the emission intensity and TMAO concentration within the 0−201 μM range, with a detection limit of 1.532 μM. Additionally, the method can measure TMAO in blood and urine samples.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mo(IV) Ion-Modulated BSA-Protected Gold Nanocluster Probe for Fluorescence Turn-On Detection of Trimethylamine N-Oxide (TMAO)

Shkhair,

Madanan,

Varghese

et al. 2024

ACS Appl. Bio Mater.

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“…The CuMnS nano ower uorescent probe has the broad detection range(Zhang et al 2022), but the experimental steps are relatively complicated. However, the detection limit of CDs prepared byAnju et al (2023) andZulfajri et al. (…”

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confidence: 99%

Detection of oxytetracycline in milk using a novel carbon dots-based fluorescence probe via facile pyrolysis synthesis

Yang

Zhang

et al. 2023

Environ Sci Pollut Res

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Amphiphilic blue-uorescence carbon dots (B-CDs) were synthesized via pyrolysis method with citric acid and oleamine as precursors. B-CDs are monodispersed in ethanol, toluene and ultrapure water with the average particle sizes of 3.33 nm, 2.05 nm and 4.12 nm, respectively. The maximum excitation and emission wavelengths of these B-CDs are located at 370 and 459 nm, respectively. The B-CDs have good optical properties with excellent photostability. The uorescence quantum yield (QY) of the as-prepared CDs is as high as 30.17%. The uorescence of B-CDs is quenched because of static quenching by oxytetracycline. A high selective and sensitive uorescence probe for detecting oxytetracycline was constructed with a linear range of 1.52-27.60 µg/mL and the detection limit of 0.33 µg/mL. The B-CDsbased uorescence probe can be applied to analyze oxytetracycline in milk; the recoveries and relative standard are satisfactory. Furthermore, the B-CDs were exploited for imaging of SH-SY5Y cells. The results demonstrated that as-synthesized CDs can serve as a cellular imaging reagent owing to rematkable bioimaging performance. This work provides a new strategy for the detection of oxytetracycline in food.

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Non‐Enzymatic Detection of Cardiac Troponin‐I with Graphene Oxide Quenched Fluorescent Iron Nanoclusters (FeNCs)

Ibrahim Shkhair,

Madanan,

Varghese

et al. 2024

Chemistry A European J

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Cardiac troponin I (cTnI) is the most resorted biomarker for the detection of cardiovascular disease (CVD). The means of rapid quantification of cTnI levels in the blood can substantially minimize the risk of acute myocardial infarction and heart failure. A sensor for the non‐enzymatic evaluation of cardiac troponin‐I has been developed using fluorescent iron nanoclusters via a one‐pot synthesis employing (BSA) as the template and reducing agent, and hydrogen peroxide as the additive. The fluorescence of Iron Nanocluster is quenched with graphene oxide (GO) via fluorescence resonance energy transfer (FRET) between conjugate iron nanoclusters and graphene oxide. The sensor shows a low detection limit of 0.013 ng/mL. The benefits of utilizing a non‐enzymatic probe for detecting cardiac troponin I is that it avoids the need for enzymes and hence is economical, stable, and less impacted by environmental conditions such as temperature and pH. Non‐enzymatic probes are more useful for clinical use since they are more stable and have a longer shelf life. The developed non‐enzymatic probes are also highly selective and sensitive to the target analyte, making them suitable for the direct detection of cardiac troponin I in actual biological samples.

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Folic acid incorporated nitrogen‐doped carbon dots as a turn‐on fluorescence probe for homocysteine detection

Cited by 6 publications

References 40 publications

Mo(IV) Ion-Modulated BSA-Protected Gold Nanocluster Probe for Fluorescence Turn-On Detection of Trimethylamine N-Oxide (TMAO)

Mo(IV) Ion-Modulated BSA-Protected Gold Nanocluster Probe for Fluorescence Turn-On Detection of Trimethylamine N-Oxide (TMAO)

Detection of oxytetracycline in milk using a novel carbon dots-based fluorescence probe via facile pyrolysis synthesis

Non‐Enzymatic Detection of Cardiac Troponin‐I with Graphene Oxide Quenched Fluorescent Iron Nanoclusters (FeNCs)

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