Folic acid-modified liposomal drug delivery strategy for tumor targeting of 5-fluorouracil

Moghimipour, Eskandar; Rezaeian, Mohsen; Ramezani, Zahra; Kouchak, Maryam; Amini, Mohsen; Angali, Kambiz Ahmadi; Dorkoosh, Farid Abedin; Handali, Somayeh

doi:10.1016/j.ejps.2017.12.011

Cited by 94 publications

(30 citation statements)

References 29 publications

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“…This effect results from shielding by the long polyethylene glycol chains, which reduces the binding of blood plasma components and interaction with macrophages, leading to increase half-life in blood circulation [ 14 , 15 ]. In addition to the classic example of PEGylation, the conjugation of liposomes to antibodies, folic acid, biotin or peptides can be used for specific tumor targeting [ 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Stability of Alkyl Chain-Mediated Lipid Anchoring in Liposomal Membranes

Gleue

Schupp

Zimmer

et al. 2020

Cells

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Lipid exchange among biological membranes, lipoprotein particles, micelles, and liposomes is an important yet underrated phenomenon with repercussions throughout the life sciences. The premature loss of lipid molecules from liposomal formulations severely impacts therapeutic applications of the latter and thus limits the type of lipids and lipid conjugates available for fine-tuning liposomal properties. While cholesterol derivatives, with their irregular lipophilic surface shape, are known to readily undergo lipid exchange and interconvert, e.g., with serum, the situation is unclear for lipids with regular, linear-shaped alkyl chains. This study compares the propensity of fluorescence-labeled lipid conjugates of systematically varied lengths to migrate from liposomal particles consisting mainly of egg phosphatidyl choline 3 (EPC3) and cholesterol into biomembranes. We show that dialkyl glyceryl lipids with chains of 18–20 methylene units are inherently stable in liposomal membranes. In contrast, C16 lipids show some lipid exchange, albeit significantly less than comparable cholesterol conjugates. Remarkably, the C18 chain length, which confers noticeable anchor stability, corresponds to the typical chain length in biological membranes.

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Section: Introductionmentioning

confidence: 99%

Stability of Alkyl Chain-Mediated Lipid Anchoring in Liposomal Membranes

Gleue

Schupp

Zimmer

et al. 2020

Cells

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“…They have seen that the addition of free folic acid to the folate-free culture medium of CT26 cells, cell viability was enhanced to 51.98 ± 6.3%. These results showed that the free folic acid stopped the FRdependent binding and uptake of NPs, which showed that the folic acid targeted NPs were up taken [88]. Lv et al showed that capsaicin loaded folate-targeted NPs showed a remarkably higher toxic effect compared to non-targeted NPs.…”

Section: Nanoparticlesmentioning

confidence: 99%

Targeted Based Drug Delivery System for Colon Cancer

Kaur

Singh

Kaur

et al. 2020

J. Drug Delivery Ther.

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Regardless of so many advancements in the treatment, colon cancer still stands third in cancer-related deaths worldwide. Toxicity associated with conventional drugs is one of the major problems associated with chemotherapy. Targeted delivery works by concentrating the medication in the tissues of interest and reducing the concentration in remaining tissues. This delivery system helps the drug molecule to reach preferably to the desired site. The targeting will lower the requirement of a higher dose of the drug thus reducing the dosage frequency. The present review focuses on the various parameters of targeted drug delivery including the criteria for selection of drug and factors affecting the targeted drug delivery and also includes the brief discussion about different targeted drug deliveries for colon cancer therapies. Keywords: colon cancer, targeted drug delivery, chemotherapies

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“…To improve cell targeting specificity, the liposomal surface can be functionalized with small molecules which possess a high binding affinity to receptors present on the cell surface. Many cancer cells overexpress folate receptors, which makes the small molecule folate a great candidate to direct the delivery of liposomes containing cancer therapeutics towards cancer cells [ 49 , 50 , 51 ]. The overexpression of sigma receptors in many cancer cell lines has paved the way for another small molecule ligand possessing a high binding affinity to these receptors: anisamide [ 52 , 53 , 54 ].…”

Section: Liposomes As Drug Delivery Vesiclesmentioning

confidence: 99%

Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery

et al. 2020

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Smart engineered and naturally derived nanovesicles, capable of targeting specific tissues and cells and delivering bioactive molecules and drugs into them, are becoming important drug delivery systems. Liposomes stand out among different types of self-assembled nanovesicles, because of their amphiphilicity and non-toxic nature. By modifying their surfaces, liposomes can become stimulus-responsive, releasing their cargo on demand. Recently, the recognized role of exosomes in cell-cell communication and their ability to diffuse through tissues to find target cells have led to an increase in their usage as smart delivery systems. Moreover, engineering “smarter” delivery systems can be done by creating hybrid exosome-liposome nanocarriers via membrane fusion. These systems can be loaded in naturally derived hydrogels to achieve sustained and controlled drug delivery. Here, the focus is on evaluating the smart behavior of liposomes and exosomes, the fabrication of hybrid exosome-liposome nanovesicles, and the controlled delivery and routes of administration of a hydrogel matrix for drug delivery systems.

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Folic acid-modified liposomal drug delivery strategy for tumor targeting of 5-fluorouracil

Cited by 94 publications

References 29 publications

Stability of Alkyl Chain-Mediated Lipid Anchoring in Liposomal Membranes

Stability of Alkyl Chain-Mediated Lipid Anchoring in Liposomal Membranes

Targeted Based Drug Delivery System for Colon Cancer

Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery

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