Folic Acid: Nutritional Biochemistry, Molecular Biology, and Role in Disease Processes

Lucock, Mark

doi:10.1006/mgme.2000.3027

Cited by 704 publications

(586 citation statements)

References 106 publications

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“…A high homocysteine phenotype accompanied by low folate is associated with increased risk of several major human pathologies including cardiovascular disease [1,2], birth defects such as spina bifida [3] and cleft palate [4], and other complications of pregnancy including spontaneous abortion, pre-eclampsia, prematurity and low birth weight [5]. Folate is required for nucleic acid biosynthesis and the methylation of lipids, hormones, DNA and proteins, while homocysteine is a key intermediate in the methylation cycle [5] and may itself be teratogenic [6,7].…”

Section: Introductionmentioning

confidence: 99%

Evidence for sex differences in the determinants of homocysteine concentrations

Stanisławska-Sachadyn

Woodside

Brown

et al. 2008

Molecular Genetics and Metabolism

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A high homocysteine phenotype, often accompanied by low folate, is associated with several pathologies including cardiovascular disease and birth defects. This phenotype appears to be influenced by both genetic and environmental factors, which may act in a sex-dependent manner. The present analyses were undertaken to identify the determinants of homocysteine concentrations in young men and women, and are based on data from a cohort of young, reproductive age (20-26 years old) individuals in Northern Ireland. Multivariate modeling indicated that homocysteine concentrations are associated with red blood cell (RBC) folate, vitamin B 12 , MTHFR 677C>T genotype and smoking status in both males and females. However, the inter-relationships between these variables appear to differ between the sexes. Specifically, homocysteine levels in males were significantly associated with interactions between MTHFR 677C>T genotype and both RBC folate and smoking status. In contrast, homocysteine levels in females were significantly associated with interactions between smoking status and RBC folate. These results suggest that the characteristics of individuals who are at the highest risk for a high homocysteine phenotype differ for males and females. Among males, those with the MTHFR 677TT genotype appear to be at the highest risk and to be the most vulnerable to factors (e.g. smoking, low RBC folate) that are associated with homocysteine raising effects. Among females, smokers (regardless of MTHFR genotype) appear to be at the highest risk, and to be the most vulnerable to a single factor (i.e. RBC folate) that is associated with homocysteine raising effects.

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Section: Introductionmentioning

confidence: 99%

Evidence for sex differences in the determinants of homocysteine concentrations

Stanisławska-Sachadyn

Woodside

Brown

et al. 2008

Molecular Genetics and Metabolism

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“…Rapidly proliferating tissues require an adequate amount of folate to satisfy cellular demands for nucleotide synthesis (Choi and Mason, 2000;Lucock, 2000). Folate is also involved in the metabolism of several amino acids, including homocysteine remethylation to form methionine.…”

Section: Introductionmentioning

confidence: 99%

“…Folate is also involved in the metabolism of several amino acids, including homocysteine remethylation to form methionine. It is then converted to the common methyl donor, S-adenosylmethionine, which is used for methylation of DNA and ptoreines (Choi and Mason, 2000;Lucock, 2000).…”

Section: Introductionmentioning

confidence: 99%

Spatial and temporal expression of folate‐binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice

Saitsu

Ishibashi

Nakano

et al. 2002

Developmental Dynamics

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Periconceptional folate supplementation is widely believed to have significant preventive effects on the production of neural tube defects. Folate-binding protein 1 (FBP1) is one of the membrane proteins that mediate cellular uptake of folate. Although recent studies suggest that Fbp1 is essential for neural tube closure, the pattern of Fbp1 expression in embryonic tissues has not been examined in detail. To elucidate how Fbp1 contributes to neural tube closure, we examined the spatial and temporal expression patterns of Fbp1 in the developing neural folds and tube of mouse embryos by in situ hybridization. Fbp1 showed a distinct expression pattern in the neural folds, which preceded initiation of neural tube closure at the cervical region and the prosencephalic/mesencephalic boundary.

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“…The hypothesis has been advanced that reproductive failure and poor pregnancy outcomes can also arise as a consequence of derangement to metabolic pathways that utilize substrates/ cofactors such as methionine, vitamin B12 and folate [48][49][50]. Physiologically relevant reductions in specific dietary Bvitamins (i.e.…”

Section: Maternal Nutritionmentioning

confidence: 99%

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Albertini

Evers²,

Geraedts³

et al. 2014

J Assist Reprod Genet

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Purpose Assisted Reproduction Treatment (ART) is here to stay. This review addresses the parental background of birth defects, before, during and after conception and focuses both on the underlying subfertility and on the question whether ART as a treatment is an additional contributing factor. Methods Searches were performed in Medline and other databases. Summaries were discussed in a Delphi panel set-up by the European Society of Human Reproduction and Embryology (ESHRE). Results Several birth defects and adult diseases arise during the earliest stages of ovarian development and oocyte differentiation: this is the case of cleft palate disorders in offspring from female rat exposed to Dioxin during fetal life or the polycystic ovary diseases in female offspring (primates) exposed to elevated androgen concentration during fetal life. Human oocytes and embryos often fail to stop the propagation of aneuploid cells but maintain their ability to repair DNA damages including those introduced by the fertilizing sperm. There is a 29 % increased risk of birth defects in the newborns spontaneously conceived by subfertile couples and the risk is further increased (34 %) when conception is achieved by treating infertlity with ART (Danish IVF Registry). Periconceptional conditions are critical for ART babies: their birth weight is in general smaller (Norvegian Registry) but a more prolonged culture time doubled the number of large babies (Finnish Registry). Conclusion The long-term developmental effects of ART on child and subsequent health as an adult remains a subject worthy of futher monitoring and investigation. Capsule Remaining mindful of the growing body of evidence showing that during gamete production, genetic and epigenetic changes influence offspring health, serves to reinforce the need to continue to monitor ART children.

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Folic Acid: Nutritional Biochemistry, Molecular Biology, and Role in Disease Processes

Cited by 704 publications

References 106 publications

Evidence for sex differences in the determinants of homocysteine concentrations

Evidence for sex differences in the determinants of homocysteine concentrations

Spatial and temporal expression of folate‐binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

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