Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Prosapio, Valentina; Marco, Iolanda De; Scognamiglio, Mariarosa; Reverchon, Ernesto

doi:10.1016/j.cej.2015.04.149

Cited by 59 publications

(38 citation statements)

References 53 publications

(65 reference statements)

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“…Numerous studies have shown that FIS possesses certain anticancer effects. Moreover, PVP, a biocompatible polymer, has been widely used in drug delivery systems to fabricate various anticancer formulations [41,46,47]. To explore these aspects, the cytotoxicity of FIS-PVP NPs and raw FIS against MDA-MB-231 cells was assessed.…”

Section: Antiproliferation Studiesmentioning

confidence: 99%

“…The improved cytotoxicity of the FIS-PVP NPs was mutually corroborated by the aforementioned experimental results: the increased solubility and dissolution rate of the drugs substantially improved their bioavailability, with anticancer effects better than those of the raw drug molecules. anticancer formulations [41,46,47]. To explore these aspects, the cytotoxicity of FIS-PVP NPs and raw FIS against MDA-MB-231 cells was assessed.…”

Section: Antiproliferation Studiesmentioning

confidence: 99%

“…Because PVP retards crystal growth and stabilizes solids in a high-energy state, it is highly suitable as a biocompatible polymer in coprecipitating crystalline drugs [40]. In this framework, previous studies have reported the successful fabrication of PVP-based nanocomposites using the SAS process [33,41].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy

Chen

et al. 2020

Nanomaterials

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Due to its hydrophobicity, fisetin (FIS) often suffers from several limitations in terms of its applicability during the fabrication of pharmaceutical formulations. To overcome this intrinsic limitation of hydrophobicity, we demonstrate here the generation of poly (vinyl pyrrolidone) (PVP)-encapsulated FIS nanoparticles (FIS-PVP NPs) utilizing a supercritical antisolvent (SAS) method to enhance its aqueous solubility and substantial therapeutic effects. In this context, the effects of various processing and formulation parameters, including the solvent/antisolvent ratio, drug/polymer (FIS/PVP) mass ratio, and solution flow rate, on the eventual particle size as well as on distribution were investigated using a 23 factorial experimental design. Notably, the FIS/PVP mass ratio significantly affected the morphological attributes of the resultant particles. Initially, the designed constructs were characterized systematically using various techniques (e.g., chemical functionalities were examined with Fourier-transform infrared (FTIR) spectroscopy, and physical states were examined with X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) techniques). In addition, drug release as well as cytotoxicity evaluations in vitro indicated that the nanosized polymer-coated particles showed augmented performance efficiency compared to the free drug, which was attributable to the improvement in the dissolution rate of the FIS-PVP NPs due to their small size, facilitating a higher surface area over the raw form of FIS. Our findings show that the designed SAS process-assisted nanoconstructs with augmented bioavailability, have great potential for applications in pharmaceutics.

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Section: Antiproliferation Studiesmentioning

confidence: 99%

Section: Antiproliferation Studiesmentioning

confidence: 99%

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Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy

Chen

et al. 2020

Nanomaterials

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“…Supercritical fluids based techniques have been proposed for the application in several fields [13][14][15][16][17] and many papers based on scCO 2 to produce micro and nanoparticles are continuously proposed [18][19][20][21][22][23]. Among scCO 2 based processes, supercritical antisolvent (SAS) precipitation has been extensively used to produce microparticles and nanoparticles of materials belonging to various industrial categories and it has been largely studied from thermodynamic, fluid dynamic and mass transfer point of view [24][25][26][27][28][29][30][31]. This process is based on two requisites: solvent and antisolvent must be completely miscible at the process conditions; whereas, solute has to be insoluble in the mixture solvent/antisolvent.…”

Section: Introductionmentioning

confidence: 99%

Production of lysozyme microparticles to be used in functional foods, using an expanded liquid antisolvent process

Prosapio

Reverchon

Marco

2016

The Journal of Supercritical Fluids

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“…Therefore, application of some techniques for reducing the particles size of spiramycin is conducive to facilitating the dissolution through enlarging the effective surface area of spiramycin. For the preparation of microparticles, many traditional approaches have been applied, including ball milling [15], mechanical comminution [16], air jet pulverization [17,18], supercritical fluid technology [19][20][21][22][23], high pressure homogenization [24,25], reactive crystallization [26], spray drying [27,28], and the antisolvent precipitation process [29]. The mechanical comminution process is a widely used method for micronizing drugs in pharmaceutical manufacturing.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process

Zhang¹,

Wu²,

Xie³

et al. 2016

Applied Sciences

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Due to its low bioavailability and slow dissolution rate, the micronized spiramycin powder was thus prepared by the homogenate-antisolvent precipitation (HAP) process. The optimum micronization conditions of the HAP process were found to be as follows: precipitation temperature of 4.6 • C, precipitation time of 10 min, spiramycin concentration of 20 mg/mL, dripping speed of the added solvent into the antisolvent of 44 mL/h, antisolvent (water) to solvent (dimethyl sulfide (DMSO)) volume ratio of 7:1, and shear rate of 5000 rpm. With this HAP process, the mean particle size was 228.36 ± 3.99 nm. The micronized spiramycin was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, high-performance liquid chromatography, and gas chromatograph analyses. In comparison with the raw drug, the chemical structure of micronized spiramycin was not changed. The dissolution rate experiments showed that the dissolution rate of the spiramycin was significantly increased after micronization. [13]. The reduction of the drug particle size to submicron range will lead to a higher oral bioavailability, which has gained much attention. Appl. Sci. 2016, 7, 10 2 of 15 micronization [13]. The reduction of the drug particle size to submicron range will lead to a higher oral bioavailability, which has gained much attention.

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Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Cited by 59 publications

References 53 publications

Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy

Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy

Production of lysozyme microparticles to be used in functional foods, using an expanded liquid antisolvent process

Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process

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