Folic acid status in normal infants during the first year of life.

Vanier, T. M.; Tyas, J. F.

doi:10.1136/adc.41.220.658

Cited by 32 publications

(20 citation statements)

References 15 publications

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“…The cord blood level of folacin was similar to the mean concentration (24.5 ng/ml) re ported by Vanier and Tyas [8], although in the latter study no relationship was seen be tween maternal and fetal levels. Folacin sup plementation has been shown to increase the concentration of folacin in both maternal and fetal blood [9], but a significant correlation between maternal and cord blood levels was demonstrated only in the unsupplemented group.…”

Section: Discussionsupporting

confidence: 83%

Proteins, Vitamin A, Carotene, Folacin, Ferritin and Zinc in Navajo Maternal and Cord Blood

Butte¹,

Calloway²

1982

Neonatology

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Blood samples were obtained from 28 Navajo women at delivery and cord blood samples were collected from their healthy, full-term infants. The concentrations of retinol, folacin, ferritin and zinc in the cord blood fell in the normal range even though some mothers had blood levels suggesting a deficiency. Levels of maternal and cord blood retinol-binding protein were positively correlated. Although marginal and deficient levels of folacin in maternal blood did not result in significantly lower cord blood levels, the strong association indicated a dependence of fetal level upon maternal supply. Birth weight and the developmental indices were not related to any of the maternal or fetal nutrient levels.

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Section: Discussionsupporting

confidence: 83%

Proteins, Vitamin A, Carotene, Folacin, Ferritin and Zinc in Navajo Maternal and Cord Blood

Butte¹,

Calloway²

1982

Neonatology

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“…Although advanced megaloblastic anemia is not common in infants without predisposing factors, the available data demonstrate laboratory evidence of mild folate deficiency in a high proportion of such infants in the first few months of life [32,38,46,51]. Infants are born with very high folate levels in serum and whole blood [12,22,38,46,56], but by 2-3 months of age the serum and blood folate levels fall to concentrations comparable to those seen in folate-deficient adults [38,46]. Rapid rates of growth and dietary factors have been thought to be responsible for this fall [38,46,56].…”

Section: Introductionmentioning

confidence: 99%

“…Infants are born with very high folate levels in serum and whole blood [12,22,38,46,56], but by 2-3 months of age the serum and blood folate levels fall to concentrations comparable to those seen in folate-deficient adults [38,46]. Rapid rates of growth and dietary factors have been thought to be responsible for this fall [38,46,56]. No data are available in the literature with regard to folate absorption in the newborn.…”

Section: Introductionmentioning

confidence: 99%

Folate Metabolism in Newborns and during Early Infancy: I. Absorption of Pteroylglutamic (Folic) Acid in Newborns

Shojania

Hornady

1970

Pediatr Res

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ExtractFolic acid (PGA) absorption (40 ,«g/kg of body weight) was studied in normal newborns and adults using Lactobacillus casei and Streptococcus faecalis microbiological assays for folate determination. The PGA was given orally or intramuscularly to the subjects after either saturating their tissues with folate or without prior saturation of their tissues. Without prior saturation of the tissues the folic acid absorption curves in newborns were much lower than those found in adults (figs. 1 and 2). Saturation of the tissues of the newborns with folic acid, prior to administration of the oral test dose, raised the absorption curves of the folic acid, but these were still lower than those seen in adults (fig: 5). The folate curve of the newborns after an intramuscular test dose of PGA was also lower than that observed in adults (fig. 3); however, after saturating the tissues of the newborns with folic acid, the folate curve became comparable to that of the unsaturated adults ( fig. 4).After the oral test dose, newborns excreted a much smaller percentage of the administered dose in their urine than did the adults (table II). When the tissues in newborns were saturated with folic acid, however, the excretion of folate in the urine became comparable to that of unsaturated adults (table II) These data indicate that: 1) plasma clearance of folate in newborns is more rapid than that in adults and that large saturating doses of folic acid are needed to reduce this clearance rate; and 2) the folate absorption curve in the newborn is lower than in the adult. With the criteria set for adults, this could be interpreted as evidence of impaired folate absorption in newborns. The proper interpretation of the data indicates, however, that folate absorption by newborns is slower than seen in adults and that the net absorption is comparable to that of adults. SpeculationIn newborns, the absorption curve for orally administered folate is lower than in adults. Our study indicates that this is due to the slower absorption of folates and more rapid tissue uptake of folates by newborns. Further studies should be carried out to investigate the absorption of folate conjugates which are the main forms of folate found in food, to determine how much of the folate in food is available to newborns and small infants, and to evaluate the need for supplementary folate in small infants. SHOJANIA and HORNADY 413

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“…Los niveles sanguineos de folato en reci£n nacidos alcanzan cifras tres a cuatro veces mayores que las correspondientes en los adultos: 18 a 24 ng/ml en suero y 563 a 598 ng/ml en gl6bu-los rojos (5,8,12,15). Estos niveles caen progresivamente despues del parto, llegando a los 6 meses de 2 a 3 ng/ml en el suero y de 100 a 180 ng/ml en los gl6bulos rojos.…”

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“…La leche humana y de vaca en polvo reconstituida contienen aproximadamente 50 jig/litro (3,5). Toda leche es por lo tanto pobre en acido folico y esta parece ser la explication para la baja de las concentraciones sanguineas de folato en los primeros meses de la vida, las cuales aumentan cuando se aporta acido folico en las verduras (12,15 (5,6,10,13), pudiendo darse por la via oral ya que su absorcion en los recien nacidos prematuros es suficiente (6,13,14). El deficit de acido folico produce aumento de megaloblastos en la medula y anemia de tipo predominantemente macrocitico.…”

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Suplemento de acido fólico: ¿Prevención de anemia en prematuros?

Beca¹,

Saieh²

1975

Rev. chil. pediatr.

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Folic acid status in normal infants during the first year of life.

Cited by 32 publications

References 15 publications

Proteins, Vitamin A, Carotene, Folacin, Ferritin and Zinc in Navajo Maternal and Cord Blood

Proteins, Vitamin A, Carotene, Folacin, Ferritin and Zinc in Navajo Maternal and Cord Blood

Folate Metabolism in Newborns and during Early Infancy: I. Absorption of Pteroylglutamic (Folic) Acid in Newborns

Suplemento de acido fólico: ¿Prevención de anemia en prematuros?

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