Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Asbaghi, Omid; Salehpour, Sara; Kelishadi, Mahnaz Rezaei; Bagheri, Reza; Ashtary‐Larky, Damoon; Nazarian, Behzad; Mombaini, Delsa; Ghanavati, Matin; Clark, Cain C. T.; Wong, Alexei; Naeini, Amirmansour Alavi

doi:10.1080/10408398.2021.1968787

Cited by 13 publications

(6 citation statements)

References 62 publications

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“…Furthermore, the lower BP that was measured in the current study, compared with the results four years ago (115/55 mmHg vs. 128/62 mmHg), may be explained by lower sodium [ 68 , 69 ] and higher plant protein [ 70 ], PUFA [ 71 ], vitamin C [ 72 ], folic acid [ 73 ], and potassium intake [ 69 , 71 ]. In addition, it is known that physical activity has beneficial effects on blood pressure [ 74 ] and that the athlete was highly active four years ago; however, she currently reported even higher weekly exercise volume (20 h/w vs. 25 h/w in 2018 and 2022).…”

Section: Discussionmentioning

confidence: 74%

Olympic Cycle Comparison of the Nutritional and Cardiovascular Health Status of an Elite-Level Female Swimmer: Case Study Report from Slovenia

Jakše

Lipošek

Zenić

et al. 2022

Sports

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Monitoring the many aspects that are crucial to an athlete’s performance progress is vital for further training planning and for the development of performance and the sport. We evaluated a four-year change (2018 vs. 2022) in the current nutritional and cardiovascular health status of the most successful elite-level female swimmer in Slovenia. Body composition and dietary intake were assessed using dual-energy X-ray absorptiometry and a standardized food questionnaire. The concentration of blood lipids, blood pressure, and serum micronutrients (B12, 25(OH)D), potassium, calcium, phosphorus, magnesium, and iron) were measured. The four-year comparison showed an improved body composition status (i.e., increased body mass and decreased body fat (percentage and mass), increased lean soft tissue and total bone mineral density (BMD) (i.e., significantly decreased BMD of a left femoral neck and increased BMD of a spine and head)). We also measured an improvement in the cardiovascular health status of some markers (i.e., decreased total cholesterol, triglycerides, and blood pressure but increased low-density lipoprotein cholesterol), most likely due to the differences in assessed dietary intake (i.e., lower carbohydrate intake, higher total and saturated fat intake, and lower sodium intake). Notably, nutrient intakes that are generally of concern (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), vitamin B12 and D, calcium, iron, and zinc (except for fiber intake)) were all within recommended ranges. However, the athlete’s vitamin K and potassium intake were not adequate. Furthermore, in 2018, the athlete did not consume dietary supplements, while she now regularly uses several dietary supplements, including EPA and DHA omega-3, vitamin D, multivitamins, carbohydrate powder, and sports drink. Moreover, from the micronutrient serum, only iron levels deviated from the reference values (37 μmol/L vs. 10.7–28.6 μmol/L). The presented screening example using valid, sensitive, and affordable methods and with rapid organizational implementation may be a viable format for regular monitoring.

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Section: Discussionmentioning

confidence: 74%

Olympic Cycle Comparison of the Nutritional and Cardiovascular Health Status of an Elite-Level Female Swimmer: Case Study Report from Slovenia

Jakše

Lipošek

Zenić

et al. 2022

Sports

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“…The NutriGrade ratings for a dietary factor were often the same for SBP and DBP and the evidence was generally for populations of mixed health statuses, the exceptions were specified. We summarized the effects of diet exposure on blood pressure and risk of hypertension in Table 1 [ [11] , [13] , [15] , [17] , [18] , [19] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [62] , [66] , [67] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [79] , [80] , [81] , [82] , [85] , [86] , [87] , [88] , [89] , [90] , [91] , [92] , [93] , [94] , [95] , [96] , [97] , [98] , [99] , [100] , [101] , [102] , [103] , [104] , …”

Section: Resultsmentioning

confidence: 99%

The Role of Diet in the Prevention of Hypertension and Management of Blood Pressure: An Umbrella Review of Meta-Analyses of Interventional and Observational Studies

Aljuraiban,

Gibson,

Chan

et al. 2024

Advances in Nutrition

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“…Folic acid is commonly used as a prenatal supplement, which may reduce the risk associated with maternal MTHFR 677CT genotype polymorphisms. A recent study discovered that taking a high-dose folic acid supplement (5 mg/day) could lower SBP and DBP 60. On the other hand, McRae MP61 examined the effect of folic acid supplementation in patients with hypertension in a previous study.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin B₂, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

Qi,

Luo,

Liu

et al. 2024

BMJ Open

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ObjectivesThe objective of the current study is to compare the treatment effects of different vitamins on essential hypertension to provide an initial basis for developing evidence-based practices.DesignSystematic review and network meta-analysis.Data sourcesFive electronic databases (PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov) were searched from their inception to 25 September 2023.OutcomesThe primary outcomes were the difference between the intervention group and the control group in changes in office systolic blood pressure (SBP) and office diastolic blood pressure (DBP) from baseline. The secondary outcomes were the difference between the intervention group and the control group in changes in 24-hour mean ambulatory systolic blood pressure (24 hours SBP), 24-hour mean ambulatory diastolic blood pressure (24 hours DBP) and heart rate (HR) from baseline.ResultsA total of 23 studies comparing five vitamins (vitamin B2, vitamin C, vitamin D, vitamin E, folic acid) and involving 2218 participants were included. The included trials were all vitamin versus placebo, so the network was star-shaped. Among the five vitamins, only vitamin E was significantly more effective at reducing SBP (mean difference: −14.14 mm Hg, 95% credible intervals: −27.62 to –0.88) than placebo. In addition, no evidence was found that any of the five vitamins influenced DBP, 24 hours SBP, 24 hours DBP, or HR. The dose of vitamins, geographical region and percentage of males (only SBP) might be sources of heterogeneity. Sensitivity and subgroup analysis revealed that the effect of vitamin intervention on blood pressure varies according to different doses of vitamins.ConclusionsAccording to the results, vitamin E might be an effective measure to reduce SBP, but more research is needed to validate this finding.PROSPERO registration numberCRD42022352332.

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Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Cited by 13 publications

References 62 publications

Olympic Cycle Comparison of the Nutritional and Cardiovascular Health Status of an Elite-Level Female Swimmer: Case Study Report from Slovenia

Olympic Cycle Comparison of the Nutritional and Cardiovascular Health Status of an Elite-Level Female Swimmer: Case Study Report from Slovenia

The Role of Diet in the Prevention of Hypertension and Management of Blood Pressure: An Umbrella Review of Meta-Analyses of Interventional and Observational Studies

Effect of vitamin B₂, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

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Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Cited by 13 publications

References 62 publications

Olympic Cycle Comparison of the Nutritional and Cardiovascular Health Status of an Elite-Level Female Swimmer: Case Study Report from Slovenia

Olympic Cycle Comparison of the Nutritional and Cardiovascular Health Status of an Elite-Level Female Swimmer: Case Study Report from Slovenia

The Role of Diet in the Prevention of Hypertension and Management of Blood Pressure: An Umbrella Review of Meta-Analyses of Interventional and Observational Studies

Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

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Product

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Effect of vitamin B₂, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis