Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site

O’Reilly, Sharleen; McGlynn, Angela Provitera; McNulty, Helene; Reynolds, John; Wasson, Gillian R.; Molloy, Anne M.; Strain, JJ; Weir, Donald G.; Ward, Mary; McKerr, George; Scott, John M.; Downes, C. Stephen

doi:10.3945/jn.115.222547

Cited by 24 publications

(26 citation statements)

References 48 publications

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“…Five percent of this population has intakes exceeding the UL of 1,000 mcg per day. This is thought mainly due to folic acid from dietary supplements [40]. One thousand mcg daily is thought excessive because some but not all literature suggests that high dose folic acid increases colon and prostate cancer risk [39].…”

Section: Commentmentioning

confidence: 99%

“…One thousand mcg daily is thought excessive because some but not all literature suggests that high dose folic acid increases colon and prostate cancer risk [39]. However, a recent study suggests 600 mg a day of folic acid reduces DNA biomarkers of cancer adjacent to colon polyp sites [40]. After multivariate adjustment, a recently published study in female US nurses showed a non-statistically significant increased risk of psoriasis to the subgroup having low dietary folate equivalent (DFE) intake among those drinking over 5 nonlight beers per week as compared to the high DFE group in this study.…”

Section: Commentmentioning

confidence: 99%

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Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

Aronson¹

2017

J Transl Sci

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The daily intake of FA of 5% Americans age 50 and over and in one study of psoriatic American women is about 1 mg. A patient with plaque psoriasis on 10 mg lisinopril did not improve on vitamins B12 and B6 alone. When folic acid 5 mg daily was added PASI improved 50%. Three cases of plaque psoriasis flared when given 1-2 mg folic acid (FA), 100 mg vitamin B6 and 1000 mcg daily B12. When daily FA was increased to 4 to 7 mg daily all three cases improved their disease.

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Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

Aronson¹

2017

J Transl Sci

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“…Folate and folic acid are rich in fruits including oranges, lemons, bananas, melons and strawberries. The randomized controlled trial conducted at Dublin hospital from O'Reilly's study demonstrated that decreased vitamin B level was associated with increased risks of colon cancer [122]. It was reported that the inverse association between vitamin B level and risk of colon cancer was related to genomic instability (mis-incorporated uracil, DNA single strand breakage and DNA repair capacity) in response to vitamin level (deficient or supplemented) in different in-vitro cell studies, rodent models and human case-control studies [123].…”

Section: Colon Cancermentioning

confidence: 99%

A Brief Review of Nutraceutical Ingredients in Gastrointestinal Disorders: Evidence and Suggestions

Gao

et al. 2020

IJMS

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The dietary effect on gut health has long been recognized through the empirical practice of soothing gastric discomfort with certain types of food, and recently the correlation between specific diets with lower incidences of several gastrointestinal diseases has been revealed. Ingredients from those considered beneficial foods have been isolated and studied, and some of them have already been put into the supplement market. In this review, we focus on latest studies of these food-derived ingredients for their proposed preventive and therapeutic roles in gastrointestinal disorders, with the attempt of drawing evidence-based suggestions on consuming these products.

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“…In all cases the malignant transformation was related to a significant decrease of SAM and global DNA hypomethylation, especially in DNA sequences where oncogenes are codified. In contrast, folic acid supplementation improved folate-related DNA biomarkers of cancer risk in colonic tissues adjacent to the former polyp site (Figure 2) [8]. Functional Food -Improve Health through Adequate Food…”

Section: Folatesmentioning

confidence: 99%

Effect of Bioactive Nutriments in Health and Disease: The Role of Epigenetic Modifications

Bautista‐García¹,

González‐López²,

González‐Esparza³

et al. 2017

Functional Food - Improve Health Through Adequate Food

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Recently, a list of clinical, physiopathological, and epidemiological studies has underlined the detrimental or beneficial role of nutritional factors in some chronic diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer. It has been described that lifestyle, environmental conditions, and nutritional compounds influence gene expression. In the last instance, it has been demonstrated that bioactive nutrimental components are important signal molecules that carry information from the external environment and could affect in biological terms, processes related to gene expression. Bioactive nutriments can work in different ways: regulating the chromatin structure or factors that directly regulate the activity of nuclear receptors. The relevance of the changes in the chromatin structure has been demonstrated by the fact that many chronic diseases and metabolic disorders are related with changes in DNA methylation patterns. For this reason, recently, the bioactive food nutriments have been investigated to characterize the molecular mechanism involved in changes of the chromatin structure, such as acetylation and methylation, and their potential benefit on chronic diseases. The dietary compounds intake involved in the regulation of epigenetic modifications can provide significant health effects and may prevent various pathological processes involved in the development of cancer and other serious diseases.

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Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site

Cited by 24 publications

References 48 publications

Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

A Brief Review of Nutraceutical Ingredients in Gastrointestinal Disorders: Evidence and Suggestions

Effect of Bioactive Nutriments in Health and Disease: The Role of Epigenetic Modifications

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