Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)

Abstract

Sleep deprivation is reported to cause oxidative stress and is hypothesized to induce subsequent aging-related diseases including chronic inflammation, Alzheimer’s disease, and cardiovascular disease. However, how sleep deprivation contributes to the pathogenesis of sleep deficiency disorder remains incompletely defined. Accordingly, more effective treatment methods for sleep deficiency disorder are needed. Thus, to better understand the detailed mechanism of sleep deficiency disorder, a sleep deprivation mouse model was established by the multiple platform method in our study. The accumulation of free radicals and senescence-associated secretory phenotype (SASP) was observed in the sleep-deprived mice. Moreover, our mouse and human population-based study both demonstrated that telomere shortening and the formation of telomere-specific DNA damage are dramatically increased in individuals suffering from sleeplessness. To our surprise, the secretion of senescence-associated cytokines and telomere damage are greatly improved by folic acid supplementation in mice. Individuals with high serum baseline folic acid levels have increased resistance to telomere shortening, which is induced by insomnia. Thus, we conclude that folic acid supplementation could be used to effectively counteract sleep deprivation-induced telomere dysfunction and the associated aging phenotype, which may potentially improve the prognosis of sleeplessness disorder patients.

The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study

“…Recent studies demonstrated that folic acid plays an important role in preventing diseases related to oxidative stress [60]. A previous study indicated that folic acid supplementation improved sleep deficiencyrelated disorders improving oxidative stress [61]. In line with our findings, the study by Baldwin et al reported reduced dietary intake of folic acid, and vitamins C and E for subjects diagnosed with OSA compared to subjects without OSA [62].…”

Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway

“…Xu et al reported miRNA-361 directly targeted Hsp90 to suppress its expression, leading to higher survival rate in cervical cancer patients (Xu et al 2020 ). Hu et al used Hsp90 inhibitor SNX2112 to treat human cervical cancer cells, and caused TRAIL-induced apoptosis of human cervical cancer cells (Hu et al 2019 ). In our study, we investigated the Hsp90 expression in clinical samples, and confirmed high Hsp90 expression in HPV16 + cervical cancer tissues.…”

Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats

“…Moderate AE decreases oxidative stress and inflammation, but excessive exercise increases the level of oxidative stress in the body (29). Studies have shown that long-term oxidative stress induces a high-load state in the heart and blood vessels and causes cardiovascular disease, including atherosclerosis, heart failure and myocardial fibrosis (30)(31)(32). Therefore, decreasing oxidative stress and inflammation is key to preventing cardiovascular system injury.…”