The Cochrane Database of Systematic Reviews 2003
DOI: 10.1002/14651858.cd004514
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Folic acid with or without vitamin B12 for cognition and dementia

Abstract: There was no beneficial effect of 750 mcg of folic acid per day on measures of cognition or mood in older healthy women. In patients with mild to moderate cognitive decline and different forms of dementia there was no benefit from folic acid on measures of cognition or mood. Folic acid plus vitamin B12 was effective in reducing the serum homocysteine concentrations. Folic acid was well tolerated and no adverse effects were reported. More studies are needed.

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Cited by 184 publications
(136 citation statements)
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“…Four small, short-duration studies of folic acid, with or without vitamin B 12 , to prevent cognitive decline in older adults found no effects (19).…”
Section: Folic Acid With or Without Vitamin B 12mentioning
confidence: 99%
“…Four small, short-duration studies of folic acid, with or without vitamin B 12 , to prevent cognitive decline in older adults found no effects (19).…”
Section: Folic Acid With or Without Vitamin B 12mentioning
confidence: 99%
“…Nel corso degli anni e grazie a numerose indagini, altre potenziali manifestazioni da carenza di folato sono emerse quali: l'iperomocisteinemia con un aumento significativo di malattie vascolari occlusive [28], già segnalate nei gravi casi di omocistinuria, alcune crisi convulsive neonatali intrattabili e responsive solo all'acido folico [29], disturbi neuropsichiatrici di tipo depressivo [30] del giovane adulto, neuropatie periferiche, degenerazione subacuta combinata del midollo spinale, demenza di Alzheimer [31], malattia di Parkinson, lo sviluppo di alcuni tipi di neoplasie e la comparsa di alterazioni preneoplastiche a carico degli epiteli gastrointestinale, della cervice uterina e del polmone [32][33][34].…”
Section: Omocisteina E Folatiunclassified
“…Da un lato, il training aumenta l'espressione di ossido nitrico sintetasi endoteliale (e-NOS), con conseguente aumento dell'attività biologica dell'ossido nitrico [70]. Tale aumento si traduce in un'accentuazione della risposta dilatatoria arteriosa all'infusione di acetilcolina, e in un aumento della risposta vasomotoria endotelio-dipendente dell'arteria brachiale [71][72][73][74]. Dall'altro, il training fisico aumenta l'attività dell'enzima superossido dismutasi, in particolar modo della subunità extracellulare (ec-SOD), che si traduce in una ridotta reazione di inattivazione dell'ossido nitrico da parte degli anioni superossido [75].…”
Section: Aspetti Fisiopatologiciunclassified
“…However, controlled trials are needed to determine whether supplementation reduces risk. Bvitamins have also been investigated in Alzheimer's disease and depression, and a meta-analysis of four randomised controlled intervention trials has provided no evidence that folic acid supplementation, with or without vitamin B 12 , has a beneficial effect on cognitive function or mood in cognitively-impaired older subjects (45) . More recently, in a trial that randomised 818 participants to 800 mg folic acid/d or placebo for 3 years the folic acid group were reported to show a better 3-year change in memory, sensorimotor speed and information processing speed than the placebo group (46) .…”
Section: B-vitaminsmentioning
confidence: 99%