Folicitin abrogates scopolamine induced hyperlipidemia and oxidative stress mediated neuronal synapse and memory dysfunction in mice

Gul, Seema; Attaullah, Sobia; Alsugoor, Mahdi H.; Bawazeer, Sami; Shah, Shahid Ali; Khan, Sanaullah; Salahuddin, Hafiza Sara; Ullah, Mujeeb

doi:10.1016/j.heliyon.2023.e16930

Cited by 3 publications

(2 citation statements)

References 114 publications

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“…The brains were carefully removed after all mice were euthanized, for protein extraction followed the protocol described in an earlier study ( Farooq et al, 2021 ; Gul et al, 2023 ).…”

Section: Methodsmentioning

confidence: 99%

“…Alzheimer's disease, a complex neurodegenerative disorder, poses significant challenges, it typically progresses in old age and affects a substantial portion of the global population ( Lucey, 2020 , Serafín et al, 2020 ). The primary features of Alzheimer's disease include extracellular accumulation of amyloid beta (Aβ) peptides (i.e., Aβ1–40 and Aβ1–42) ( Gul et al, 2023 ) and intracellular accumulation of neurofibrillary tangles (i.e., insoluble hyperphosphorylated tau protein) ( Majdi et al, 2020 , Saeed et al, 2020 , Shah et al, 2015 , Winny Yun et al, 2021 ). Multiple factors have been attributed to Alzheimer's disease’s pathogenesis, therefore exact mechanism underlying this disease remains elusive ( Gadhave et al, 2021 , Uddin et al, 2020 , Wang et al, 2020 , Zhu et al, 2020 ), although, Aβ accumulation and oxidative stress are widely accepted major factors responsible for Alzheimer's disease ( Ullah et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Ranuncoside’s attenuation of scopolamine-induced memory impairment in mice via Nrf2 and NF-ĸB signaling

Sara Salahuddin,

Attaullah,

Ali Shah

et al. 2023

Saudi Pharmaceutical Journal

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“…The brains were carefully removed after all mice were euthanized, for protein extraction followed the protocol described in an earlier study ( Farooq et al, 2021 ; Gul et al, 2023 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ranuncoside’s attenuation of scopolamine-induced memory impairment in mice via Nrf2 and NF-ĸB signaling

Sara Salahuddin,

Attaullah,

Ali Shah

et al. 2023

Saudi Pharmaceutical Journal

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Heat-Killed Lactococcus Lactis KC24 Ameliorates Scopolamine-Induced Memory Impairment in ICR Mice

Lee,

Park

et al. 2024

Probiotics & Antimicro. Prot.

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Alleviative effect of scopolamine‑induced memory deficit via enhancing antioxidant and cholinergic function in rats by pinostrobin from Boesenbergia rotunda (L.)

Thongrong,

Promsrisuk,

Sriraksa

et al. 2024

Biomed Rep

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Pinostrobin, a key bioactive compound found in the medicinal plant Boesenbergia rotunda (L.), has been noted for its beneficial biological properties including antioxidant, anti-inflammation, anti-cancer and anti-amnesia activities. In view of this, the present study purposed to evaluate the neuroprotective potential of pinostrobin in reversing scopolamine-induced cognitive impairment involving oxidative stress and cholinergic function in rats. A total of 30 male Wistar rats were randomly divided into five groups (n=6): Group 1 received vehicle as a control, group 2 received vehicle + scopolamine (3 mg/kg, i.p.), group 3 received pinostrobin (20 mg/kg, p.o.) + scopolamine, group 4 received pinostrobin (40 mg/kg, p.o.) + scopolamine and group 5 received donepezil (5 mg/kg, p.o.) + scopolamine. Treatments were administered orally to the rats for 14 days. During the final 7 days of treatment, a daily injection of scopolamine was administered. Scopolamine impaired learning and memory performance, as measured by the novel object recognition test and the Y-maze test. Additionally, oxidative stress marker levels, acetylcholinesterase (AChE) activity, choline acetyltransferase (ChAT) and glutamate receptor 1 (GluR1) expression were determined. Consequently, the findings demonstrated that the administration of pinostrobin (20 and 40 mg/kg) markedly improved cognitive function as indicated by an increase in recognition index and by spontaneous alternation behaviour. Pinostrobin also modulated the levels of oxidative stress by causing a decrease in malondialdehyde levels accompanied by increases in superoxide dismutase and glutathione activities. Similarly, pinostrobin markedly enhanced cholinergic function by decreasing AChE activity and promoting ChAT immunoreactivity in the hippocampus. Additionally, the reduction in GluR1 expression due to scopolamine was diminished by treatment with pinostrobin. The findings indicated that pinostrobin exhibited a significant restoration of scopolamine-induced memory impairment by regulating oxidative stress and cholinergic system function. Thus, pinostrobin could serve as a potential therapeutic agent for the management of neurodegenerative diseases such as Alzheimer's disease.Alleviative effect of scopolamine-induced memory deficit via enhancing antioxidant and cholinergic function in rats by pinostrobin from Boesenbergia rotunda (L.

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Folicitin abrogates scopolamine induced hyperlipidemia and oxidative stress mediated neuronal synapse and memory dysfunction in mice

Cited by 3 publications

References 114 publications

Ranuncoside’s attenuation of scopolamine-induced memory impairment in mice via Nrf2 and NF-ĸB signaling

Ranuncoside’s attenuation of scopolamine-induced memory impairment in mice via Nrf2 and NF-ĸB signaling

Heat-Killed Lactococcus Lactis KC24 Ameliorates Scopolamine-Induced Memory Impairment in ICR Mice

Alleviative effect of scopolamine‑induced memory deficit via enhancing antioxidant and cholinergic function in rats by pinostrobin from Boesenbergia rotunda (L.)

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