2024
DOI: 10.1002/jdn.10402
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Folinic acid as a treatment for autism in children: A within‐subjects open‐label study on safety and efficacy

Chui Mae Wong,
Charmain Samantha Tan,
Hwan Cui Koh
et al.

Abstract: The folate cycle has been implicated in the pathophysiology of autism due to its role in the glutathione oxidative stress pathway, amino acid and DNA methylation reactions, and neurotransmitter synthesis pathway. Previous research on folinic acid supplementation in autistic children has suggested potential benefits. The primary aim of this pilot study was to determine the safety, feasibility and efficacy of oral folinic acid in improving communication and behaviour in autistic children. Ten autistic children w… Show more

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