Folkloric Medicinal Plants:Tinospora sagittatavar.cravanianaandMahonia bealei

Abstract

skin infections (10). In recent years, a preparation from this plant, obtained by cooking the root powder in water, followed by filtration and precipitation from a NaC1 solution, has shown therapeutic effects in treating dysentery in over 500 patients. In clinical trials, the length of treatment was significantly shorter, and side-effects were milder, when compared to berberine. Animal toxicity tests of this preparation indicated a LD50 of 34 mg/kg in rats. Jatrorrhizine was subsequently isolated from this preparation as a major component (ca. 0.5 % plant weight), and identified by direct compaiison with an authentic sample (co-TLC, NMR, MS). Jatrorrhizine has been found in many Mahonia plants (11), but this is the first report of its occurrence in M. bealei. In our hands, the alkaloid was toxic to P388 cells (ED50 2.0 g/ml) and the brine shrimps (LD50 0.2 p.g/ml), but was inactive in antibacterial assays against F. coli, Streptococcus aureus, or Bacillus subtilis, at concentrations up to 100 .tg/ml.

Neuroprotective activity of Ethanolic Extract of Tinospora cordifolia on LPS induced Neuroinflammation

“…It is widely used in veterinary folk medicine, ayurvedic system of medicine for its general tonic, anti-diabetic, antipyretic, antispasmodic, anti-arthritic, antioxidant, anti-allergic, anti-stress, anti-inflammatory etc [15][16][17][18]. In the present study, we have investigated the effect of Ethanolic Extract of Tinospora cordifolia (EETC) which attenuates LPS induced neuroinflammation by down-regulating the levels of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, COX, NOS etc.…”

Evaluation of the Antineoplastic Activity of Guduchi (Tinospora cordifolia) in Ehrlich Ascites Carcinoma Bearing Mice

“…7,8) Guduchi has been reported to be active against throat cancer in man and it has been reported to be non-toxic in acute toxicity studies in vivo, with almost no side effects. [9][10][11] A variety of constituents have been isolated from T. cordifolia and their structures elucidated.…”

“…Guduchi is widely used in veterinary folk medicine and Ayurvedic system of medicine for its general tonic, antiperiodic, anti-spasmodic, anti-inflammatory, antiarthritic, anti-allergic and antidiabetic properties. [5][6][7] The whole plant is used in Ayurvedic "Rasayanas" to improve the immune system and the body resistance against infections and root is known for its antistress, anti-leprotic and anti-malarial activities. 7,8) Guduchi has been reported to be active against throat cancer in man and it has been reported to be non-toxic in acute toxicity studies in vivo, with almost no side effects.…”

“…[5][6][7] The whole plant is used in Ayurvedic "Rasayanas" to improve the immune system and the body resistance against infections and root is known for its antistress, anti-leprotic and anti-malarial activities. 7,8) Guduchi has been reported to be active against throat cancer in man and it has been reported to be non-toxic in acute toxicity studies in vivo, with almost no side effects. [9][10][11] A variety of constituents have been isolated from T. cordifolia and their structures elucidated.…”

“…Leaves of T. cordifolia are rich in protein (11.2%) and are fairly rich in calcium and phosphorus. 7,12) Alkaloids like berberine, palmatine, tembetarine and magnoflorine have been isolated from the stem of T. cordifolia. The roots of T. cordifolia are also reported to contain other alkaloids like choline, tinosporin, isocolumbin, palmatine, tetrahydropalmatine and magnoflorine.…”