Follicle‐associated epithelium and medullary epithelial tissue of the bursa of Fabricius are two different compartments

Oláh, Imré; Glick, Bruce

doi:10.1002/ar.1092330412

Cited by 42 publications

(45 citation statements)

References 23 publications

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“…This epithelial line, whose basal lamina was continuous with that of the IFE, was positive to antikeratin (Viamontes et al, 1989;Olah and Glick, 1992) and anti-bursin antibodies (Viamontes et al 1989). During embryogenesis, the epithelial cells, together with the bud formation, expressed K1 antigen, and after hatching, this antigen was restricted to cortico-medullary and FAE cells (Olah et al, 2002).…”

Section: Cortico-medullary Epithelial Linementioning

confidence: 95%

“…The IFE was reactive to anti-cytokeratin antibody (Viamontes et al, 1989;Olah and Glick, 1992).The basal layer lining the IFE contained bursin (Viamontes et al, 1989;Otsubo et al, 2001).The origin of FAE cells is controversial. It has been reported that the FAE cells are epithelial cells (Schaffner et al, 1974a;Schaffner et al, 1974b;Davenport and Allen, 1995;Paramithiotis and Ratcliffe, 1996), which are positive (Viamontes et al, 1989), or weakly positive (Olah and Glick, 1992) to anti-cytokeratin antibodies. Other authors reported that they are mesenchymal cells (Dolfi et al, 1981;Lupetti et al, 1983Lupetti et al, , 1986Lupetti et al, 1990), that are negative to anti-cytokeratin .…”

Section: Plical Epitheliummentioning

confidence: 99%

“…Through ultrastructural studies, Olah and Glick (1992) noticed that the FAE was supported by 3 to 5 layers of stratified epithelial cells which were a continuation of the cortico-medullary epithelial cells, and was constituted of M cells and scattered secretory dendritic cells. Romano et al, (1996) found that the FAE was organized in multistratified polygonal cells and lacked a basal lamina; underneath these multistratified polygonal cells there were FAE-supporting cells which separated the FAE from the medullary environment.…”

Section: Plical Epitheliummentioning

confidence: 99%

“…The reticular-epithelial cells detected during embryonic development (Jolly, 1914;Ackerman and Knouff, 1959;Ackerman, 1962;Lupetti et al, 1990) or in adult life (Frazier, 1974;Glick, 1983;Houssaint et al, 1986;Eerola et al, 1987;Dolfi et al, 1990;Olah and Glick, 1992) have been described by ultrastructural studies (Frazier, 1974) and classified as pale, dark and intermediate cells. These cells had cytoplasmic processes which were often connected to the adjacent epithelial cells forming a supporting network for the lymphocytes.…”

mentioning

confidence: 99%

“…Other cells in the medulla were free. They could be stained by anti-cytokeratin sera (Viamontes et al, 1989;Dolfi et al, 1990;Lupetti et al, 1990;Olah and Glick, 1992) and detected by specific monoclonal antibodies (Houssaint et al, 1986;Houssaint, 1987;Boyd et al, 1990).…”

mentioning

confidence: 99%

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Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: II. Bursa of Fabricius

Mazzone¹,

Aita²,

Gabrielli³

et al. 2009

Eur J Histochem

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The Bursa of Fabricius of 15 day, 1-, 3-, and 6 month-old adult chickens (White Leghorn strain) were studied by histological and histochemical staining, histoenzymatic reactions (LDH, SDH, α-GPDH, NAD, NADPH, Ca ++ -dependent ATP-ase, pH 8.5) and by anti-thymostimulin immunoreaction. Positive reactions for mucopolysaccharides and enzymatic activities were located in the epithelia of the follicles, i.e. in follicleassociated-epithelium (FAE), inter-follicle-epithelium (IFE) and in different epithelial compartments of cortical and medullary zones. Positive reaction for thymostimulin-like (TSlike) substance was restricted to FAE cells and weakly to the basal lamina of IFE. In 6-month-old chickens, the FAE cells disappeared; the phenomenon of bursal regression was evident, although not all the follicles were involved. In the few still normal follicles, the good reactivity to the enzymes tested suggests that residual physiological activity is still present, even if reduced. , 1621) is a primary lymphoid organ peculiar to birds. The bursa is responsible for the maturation and differentiation of B-lymphocytes to produce humoral immunological responses. The other primary lymphoid organ, the thymus, instead, is responsible for the maturation and differentiation of T-lymphocytes, leading to cellular immunological responses (Dent and Good, 1965;Schaffner et al., 1974a;Le Douarin et al., 1984).The structure of the bursa has been described both during the ontogenetic period (Jolly, 1911a(Jolly, , 1914Cordier, 1969;Edwards et al., 1975;Le Douarin et al., 1975;Le Douarin et al., 1976;Le Douarin et al., 1984;Ritter and Lebacq, 1977) and during the posthatching period up to its involution (Jolly, 1911b(Jolly, ,1914Mc Connachie and Ruth, 1973;Glick, 1974Glick, , 1983Bellamy and Mohamed, 1982;Davenport and Allen, 1985).Since the discovery that the bursa was implicated in the differentiation of B-lymphocytes for humoral immunity (Chang et al., 1955;Glick et al., 1956;Papermaster and Good, 1962;Peterson and Good, 1965), attention was focused, on the one hand, on lymphoid cell populations (Ackermann and Knouff, 1959;Ackermann, 1962;Woods and Linna, 1965;Cooper et al., 1966; Toivanen et al., 1972 a,b;Toivanen et al., 1974;Back et al., 1973;Grossi et al., 1974;Grossi et al., 1976;Glick, 1974Glick, , 1983Glick, , 1995Glick et al., 1975;Eerola et al., 1982;Brand et al., 1983;Pink et al., 1985;Lassila, 1989;Nowak et al., 1990;Motyka and Reynolds, 1991;Petrini et al., 1991;Paramithiotis and Ratcliffe, 1993, 1994 a,b, 1996Reynaud and Weill, 1993;Masteller and Thompson, 1994;Masteller et al., 1995;Paramithiotis et al., 1995;Obranovich and Boyd, 1996;Funk and Thompson, 1996) and, on the other hand, on the epithelial stroma providing the bursal microenvironment within which B-cell maturation and differentiation occurs.

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Section: Cortico-medullary Epithelial Linementioning

confidence: 95%

Section: Plical Epitheliummentioning

confidence: 99%

Section: Plical Epitheliummentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: II. Bursa of Fabricius

Mazzone¹,

Aita²,

Gabrielli³

et al. 2009

Eur J Histochem

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Distribution of bursal secretory dendritic cells in the chicken

et al. 1996

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Background The bursa of Fabricius provided the microenvironment for B‐cell differentiation. Continuous contact between lymphoid cells and antigen in the bursa further suggested that antigenic material has an important influence on the maintenance and development of B cells in the bursa. In addition, a dendritic cell, the bursal secretory dendritic cell (BSDC), has been identified in the medulla. The hypothesis that, in the bursal follicles, the contact between the lymphoid cells and the antigen may be mediated by dendritic cells prompted us to identify a bursal dendritic cell that becomes activated after contact with the antigen. Methods A polyclonal antiserum to S‐100 protein was used to identify bursal dendritic cells because S‐100 protein, a calcium‐binding protein, has been shown to be a marker for the identification of chicken dendritic cells following recent contact with antigen. Results At every age investigated, S‐100‐positive cells showed a location and shape identical to those described for BSDCs. Positive cells were found within and under the follicle‐associated epithelial cells (FAE), indicating that these cells were strategically placed where they would encounter the antigen. In addition, positive cells were found arranged along the corticomedullary junction, which is a regenerative zone for the BSDC. After 10 weeks of age, the number of positive cells dramatically decreased, suggesting that the endocytic activity of the FAE may become impaired as the bursa regresses. Conclusions The polyclonal antiserum to S‐100 protein identified the BSDCs in the bursal follicles. Positive cells may be BSDCs that have undergone a functional activation after contact with the antigen. These cells may have a role as antigen‐presenting cells in the bursal follicles. Hence, these cells may be involved in the events that lead to B‐cell differentiation. © 1996 Wiley‐Liss, Inc.

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Age-related changes in the medullary reticular epithelial cells of the pigeon bursa of fabricius

et al. 1996

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Follicle‐associated epithelium and medullary epithelial tissue of the bursa of Fabricius are two different compartments

Cited by 42 publications

References 23 publications

Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: II. Bursa of Fabricius

Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: II. Bursa of Fabricius

Distribution of bursal secretory dendritic cells in the chicken

Age-related changes in the medullary reticular epithelial cells of the pigeon bursa of fabricius

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