Follicle stimulating hormone levels on cycle day 3 predict ovulation stimulation response

Ebrahim, A K; Rienhardt, G.; Morris, S.; Kruger, T. F.; Lombard, Carl; Merwe, J. P. van der

doi:10.1007/bf01207735

Cited by 29 publications

(14 citation statements)

References 18 publications

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“…Serum FSH levels rise to compensate for a diminished ovarian response to stimulation. Since Scott and colleagues 4 reported the predictive value of day-3 serum FSH levels for IVF outcome, several studies have been performed to determine the importance of day-3 FSH concentration [5][6][7][8][9] . The threshold values as demonstrated by the number of mature oocytes collected have varied between 10.8 and 25.0 mIU/ml.…”

Section: Discussionmentioning

confidence: 99%

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Prediction of ovarian reserve based on day-3 serum follicle stimulating hormone concentrations during the pituitary suppression cycle using a gonadotropin releasing hormone agonist in patients undergoingin vitrofertilization–embryo transfer

Onagawa

Shibahara

Ayustawati

et al. 2004

Gynecological Endocrinology

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Satisfactory results following in vitro fertilization-embryo transfer (IVF-ET) treatments depend on retrieving an appropriate number of mature oocytes without causing the development of ovarian hyperstimulation syndrome (OHSS). The present study was carried out to investigate whether the ovarian reserve is predictable based on the day-3 serum concentration of follicle stimulating hormone (FSH) during the pituitary suppression cycle using a gonadotropin releasing hormone (GnRH) agonist (defined as day-3 FSH) in patients undergoing IVF-ET treatment. Day-3 FSH before the administration of gonadotropin was assessed in 72 IVF-ET cycles from 59 infertile women. The mean+/-SD of day-3 FSH, the total amount of FSH plus human menopausal gonadotropin (hMG) administered, and the total number of oocytes retrieved was 5.5+/-2.6 mIU/ml, 2834.2+/-1236.5 IU and 7.7+/-5.8, respectively. There were significant correlations between day-3 FSH and the total amount of FSH-hMG administered (p < 0.001), and day-3 FSH and total number of oocytes retrieved (p < 0.001). There was a significant difference of day-3 FSH between patients who subsequently conceived (4.4+/-1.3 mIU/ml) and those who did not conceive (6.1+/-2.9 mIU/ml) (p = 0.001). There was also a significant difference of day-3 FSH between patients who developed moderate or severe OHSS (4.5+/-1.2 mIU/ml) and those who did not (5.9+/-2.8 mIU/ml) (p = 0.003). Receiver-operator characteristic curve analysis showed that the significant cut-off point for day-3 FSH for predicting ovarian reserve was 5.25 mIU/ml. These findings indicate that day 3-FSH is usefulfor predicting ovarian reserve during the pituitary suppression cycle using a GnRH agonist in patients undergoing IVF-ET.

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Section: Discussionmentioning

confidence: 99%

“…Regarding FSH concentration, previous studies have utilized the value in the early follicular phase of the natural cycle [4][5][6][7][8][9] . However, there has also been a report of a practical method for determination of FSH in the IVF cycle induced by GnRH agonist suppression 14 .…”

Section: Introductionmentioning

confidence: 99%

Prediction of ovarian reserve based on day-3 serum follicle stimulating hormone concentrations during the pituitary suppression cycle using a gonadotropin releasing hormone agonist in patients undergoingin vitrofertilization–embryo transfer

Onagawa

Shibahara

Ayustawati

et al. 2004

Gynecological Endocrinology

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“…There have been controversies concerning the cutoff value of basal serum FSH level that could represent the ovarian response according to the laboratories and the assay technique used. 21,22) In this study, we used the concentration of 8.5 mIU/ ml as the cutoff value of ovarian response by our results of the previous study.R) However, there is also intercycle variability of basal serum FSH22,23) and the single measurement of basal serum FSH is not seemed to be accurate for prediction of ovarian response. It was reported that the patients with low basal serum FSH level had also minimal intercycle variation of FSH level than those with high basal serum FSH however, it is possible that the patients with low basal serum FSH level at the measurement have actually high basal serum FSH level at commencement of COH.…”

Section: Discussionmentioning

confidence: 99%

Clinical Usefulness of Basal FSH as a Prognostic Factor in Patients Undergoing Intracytoplasmic Sperm Injection*

Chae

Kim

Kang

et al. 2000

J of Obstet and Gynaecol

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“…Ovarian responsiveness has previously been shown to be related to FSH levels early in the same cycle without pituitary desensitisation (Toner et al 1991; Ebrahim et al 1993). We have shown that this association holds when FSH is measured in an earlier cycle, which should be of greater practical predictive value.…”

Section: Discussionmentioning

confidence: 99%

Relative influence of serum follicle stimulating hormone, age and other factors on ovarian response to gonadotrophin stimulation

Cahill

Prosser

Wardle

et al. 1994

BJOG

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Objective To determine the relative value of the woman's age, basal follicle stimulating hormone (FSH), basal luteinising hormone (LH) and menstrual cycle pattern (all denned prior to treatment) in predicting the ovarian response to gonadotrophin stimulation for in vitro fertilisation. Design Open, descriptive cohort study. Patients One hundred and seventy‐one consecutive ovulatory women undergoing their first cycle of in vitro fertilisation with ovarian stimulation after pituitary desensitisation. Interventions Measurement of basal (early follicular phase) and down‐regulated concentrations of serum FSH and LH, and calculation of age at treatment and of median length of menstrual cycles and range of variation prior to treatment. Main outcome measures Duration and amount of gonadotrophin stimulation to achieve follicular maturity, number of mature follicles, peak serum oestradiol concentration and number of mature oocytes, were compared between banded values of variables studied. Results Increasing basal FSH concentrations were significantly associated with reducing oestradiol levels, numbers of mature follicles and oocyte yield even when the FSH levels were still within the normal range though above average (6 to 8.9 i.u./l). There were similar but weaker associations with FSH levels after down‐regulation. There were also significant differences between women over and under 40 years old in their oestradiol levels, numbers of follicles and of oocytes. Analysis of variance showed significant independent association of basal FSH with both oestradiol and numbers of oocytes, but not of age, menstrual pattern, or serum LH concentrations. Conclusion Serum FSH is more sensitive than the woman's age in determining her ovarian responsiveness to stimulation. LH concentrations and menstrual cycle patterns are unhelpful.

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Follicle stimulating hormone levels on cycle day 3 predict ovulation stimulation response

Abstract: Cycle day 3 FSH levels are predictive of the ovulation response and probability of pregnancy in stimulated cycles and can be of value in patient selection and counseling in IVF and GIFT programs.

Cited by 29 publications

References 18 publications

Prediction of ovarian reserve based on day-3 serum follicle stimulating hormone concentrations during the pituitary suppression cycle using a gonadotropin releasing hormone agonist in patients undergoingin vitrofertilization–embryo transfer

Prediction of ovarian reserve based on day-3 serum follicle stimulating hormone concentrations during the pituitary suppression cycle using a gonadotropin releasing hormone agonist in patients undergoingin vitrofertilization–embryo transfer

Clinical Usefulness of Basal FSH as a Prognostic Factor in Patients Undergoing Intracytoplasmic Sperm Injection*

Relative influence of serum follicle stimulating hormone, age and other factors on ovarian response to gonadotrophin stimulation

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