Follicular atresia in the infant human ovary

Himelstein-Braw, Ruth; Byskov, Anne Grete; Peters, Hannah; Faber, Mogens

doi:10.1530/jrf.0.0460055

Cited by 124 publications

(25 citation statements)

References 11 publications

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“…This confirms previous observations that follicle growth and atresia occur throughout infancy and childhood (Block, 1952;Valdes-Dapena, 1967;Lintern-Moore et al, 1974;Peters, et al, 1975Peters, et al, , 1976 The present findings show that most of the ovaries of leukaemic children were abnormal. Leukaemic infiltration of the ovary occurred in only one case.…”

Section: Discussionsupporting

confidence: 92%

“…Some of them were "healthy", showing no signs of atresia, others were in different stages of atresia, characterized by pyknotic granulosa cells, necrotic oocytes, collapsing follicles and "scars" of large follicles (Watzka, 1957;Himelstein-Braw et al, 1976).…”

Section: Methodsmentioning

confidence: 99%

“…NORMAL development of the ovary during infancy and childhood is characterized by follicle growth and atresia (Block, 1952;Valdes-Dapena, 1967;Lintern-Moore et al, 1974;Peters et al, 1976). However, there are also reports that there is no evidence of follicle growth in prepubertal ovaries (von Stieve, 1949;van Wagenen and Simpson, 1973).…”

mentioning

confidence: 99%

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Morphological study of the ovaries of leukaemic children

Himelstein-Braw¹,

Peters²,

Faber³

1978

Br J Cancer

145

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Summary.-The ovaries of leukaemic children were studied in 31 specimens obtained at autopsy. Twenty-eight ovaries from normal children of the same age who died from misadventure served as control. All ovaries from normal children showed follicle growth and contained several large antral follicles.Follicle development was inhibited in all ovaries of leukaemic children; 22% showed no follicle growth (quiescent ovaries), and in the ovaries in which there was follicle development, the number and size of antral follicles was significantly smaller than in the control. All children had been treated with cytotoxic drugs, the duration of the treatment being correlated with the stage of ovarian development. The ovaries of children treated for only 1 week were near-normal, while those treated for more than 2 months showed inhibition of follicle growth. It is argued that the disturbance in follicle development is an effect of the cytotoxic drugs, and not an effect of the disease itself.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Morphological study of the ovaries of leukaemic children

Himelstein-Braw¹,

Peters²,

Faber³

1978

Br J Cancer

145

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“…7). However, it differed from that in mice (Oakberg, 1979), guinea pigs (Adams and Hertig, 1964), rabbits (Nicosia et al, 1975), cats (Jewgenow and Stolte, 1996), monkeys (Zamboni, 1974) and humans (Himelstein-Braw et al, 1976) in which the ZP forms around the oocyte in primary follicles. Electron-dense droplets in the cytoplasm of both the oocyte and granulosa cells of secondary follicles were detected in this study, and these droplets were strongly dyed by the Schiff's reagent in histological sections confirming their glycoproteic content.…”

Section: Discussionmentioning

confidence: 86%

Light microscopical and ultrastructural characterization of goat preantral follicles

Lucci

Silva

Carvalho

et al. 2001

Small Ruminant Research

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Light microscopical and ultrastructural characterization of goat preantral follicles AbstractGoat ovarian preantral follicles were morphologically and ultrastructurally described in this work. Primordial follicles are oocytes surrounded by one layer of squamous or squamouscuboidal granulosa cells; primary follicles have a single layer of cuboidal granulosa cells, and secondary follicles are oocytes surrounded by two or more layers of cuboidal granulosa cells. At all developmental stages a thick layer of glycoproteins, the basement membrane, surrounded the preantral follicles. The quiescent oocyte is spherical or oval and it has a large eccentrically located nucleus with a conspicuous nucleolus. The organelles were uniformly distributed in the cytoplasm. A large number of vesicles were spread throughout the cytoplasm in all the oocytes. The cytoplasm of oocytes also contains numerous rounded mitochondria besides the usual organelles. As the follicle develops, the mitochondria become elongated. The communication between the oocyte and the granulosa cells is apparently mediated through endocytosis as indicated by the abundant coated pits and vesicles noted in the cortical cytoplasm of the oocyte. The oocyte plasma membrane presented projections that penetrated between adjacent granulosa cells and a few short microvilli lying parallel to the oocyte surface. In secondary follicles, patches of zona pellucida material were observed. Overall, the results indicate that the morphological and ultrastructural organization of caprine preantral follicles resembles that of other mammals. However, some particularities were observed, and that may indicate species specific differences.

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“…After the midgestational peak, there is significant apoptotic loss of germ cells, resulting in only 1 to 2 million total oocytes present at birth. 9 Germ cell content continues to decrease throughout the female life span, ultimately resulting in complete oocyte depletion during menopause. It is generally accepted that, once all oocytes are lost, no mechanism or opportunity exists to generate new oocytes.…”

Section: Fertility Preservationmentioning

confidence: 99%