Follicular Atresia in the Ovaries of Nonmammalian Vertebrates

Saidapur, Srinivas K.

doi:10.1016/s0074-7696(08)60169-2

Cited by 129 publications

(103 citation statements)

References 52 publications

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“…Notably, the observed degenerative changes (zona radiata breakdown, follicle involution, and hypertrophy of granulosa cells; Fig. 2B) are consistent with the histological features of ovarian follicle atresia in teleosts, including zebrafish (Saidapur, 1978;Wood and Van Der Kraak, 2001). These observations suggest a relatively rapid onset of oocyte demise, but importantly, indicate continued normal function of ovarian somatic cells (e.g., follicular epithelium), suggesting an absence of bystander or off-target effects of prodrug treatment.…”

Section: Mtz Treatment Inducessupporting

confidence: 81%

A transgenic zebrafish model of targeted oocyte ablation and de novo oogenesis

White¹,

Woods²,

Wood³

2011

Developmental Dynamics

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We describe here a novel transgenic zebrafish, Tg(zpc:G4VP16/UAS:nfsB-mCherry) that effectively demonstrates the targeted oocyte ablation in the adult zebrafish ovary. This transgenic line expresses bacterial nitroreductase enzyme (nfsB) under the control of the oocyte-specific zona pellucida C (zpc) gene promoter. Adult transgenic females exposed to the prodrug metronidazole demonstrated near-complete ablation of growing oocytes, resulting in ovarian degeneration and complete cessation of reproductive function. Within 4 weeks of prodrug removal, treated fish demonstrated complete anatomical regeneration of the ovary and, within 7 weeks, ovarian function (fertility) was fully restored. Together, these results demonstrate functional renewal of the oocyte pool in the adult zebrafish ovary. Accordingly, this transgenic zebrafish model system provides a novel means to investigate ovarian growth dynamics in a genetically tractable vertebrate, and may be useful for evaluating signaling interactions that regulate gonadal development processes such as de novo oogenesis.

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Section: Mtz Treatment Inducessupporting

confidence: 81%

A transgenic zebrafish model of targeted oocyte ablation and de novo oogenesis

White¹,

Woods²,

Wood³

2011

Developmental Dynamics

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“…Possibly this is the most likely explanation why earlier workers, who examined only a few representative sections of the ovary, did not appre¬ ciate such frequent occurrence of bursting atresia in the hen (Fell, 1925;Deol, 1955;Uhrin, 1984) or most other birds (see references in Gupta & Maiti, 1986). Different kinds of atretic structures considered earlier to be the involution or invasion type (Saidapur, 1978;Gilbert, 1979) were in fact always found in semi-serial sections to be of Type 2. What causes rupture of the follicular wall remains unknown.…”

Section: Non-bursting Atresia (Type 1)mentioning

confidence: 91%

“…Confusingly, similar names appear to have been used for dissimilar atretic structures and vice versa. In their reviews, Saidapur (1978) and Gilbert (1979) categorized all the atretic structures within the avian ovary which were described in earlier papers into two basic types, i.e. bursting and involution atresia.…”

Section: Introductionmentioning

confidence: 99%

Histological study of follicular atresia in the ovary of the domestic hen (Gallus domesticus)

Gupta¹,

Gilbert²,

Walker³

1988

Reproduction

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Summary. Semi-serial (1 in 20) sections of ovaries were studied and only two types of atresia were identified\p=m-\non-bursting and bursting. Smaller, non-yolky follicles (< 1 mm diameter) showed non-bursting atresia. Atresia in follicles > 1 mm diameter was invariably of the bursting type which involved the rupture of the follicular wall, and the extrusion of yolk and cellular debris through the rupture site into the stroma. However, this rupture site was small and consequently was not visible in every section but it could always be seen when the follicle was followed in semi-serial sections. The mitotic index of granulosa cells in bursting atretic follicles was much lower than that for normal follicles.The most common criteria for distinguishing non-bursting atretic follicles were the extremely shrunken, irregularly shaped oocytes and the separation of the granulosa from the theca. In bursting atretic follicles, reliable indications were the presence in the ooplasm of some cells or cellular debris, and disorganization of the yolk and granulosa tissue. The presence of pycnotic nuclei in the granulosa cells was not a consistent feature of all atretic follicles of the hen.

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“…This results in the regression of the tissue (Bursch et al, 1990a). Sim-ilarly, ovarian atrophy (atresia) can be induced in vertebrates by various techniques affecting the gonadotrophin levels (Saidapur, 1978;Gilbert et al, 1981;Tanabe et al, 1981; Yoshimura and Tamura, 1985). Food deprivation or starvation has often been used for this purpose (Verheyen et al, 1987;Saidapur et Prasadmurthy, 1988).…”

Section: Introductionmentioning

confidence: 99%