Follicular Bronchiolitis Associated with Rheumatoid Arthritis.

Kinoshita, Masaharu; Higashi, Toshihiro; Tanaka, Chikako; Takahashi, Naoto; Ichikawa, Yoichiro; Ōizumi, Kōtaro

doi:10.2169/internalmedicine.31.674

Cited by 40 publications

(14 citation statements)

References 9 publications

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“…The therapeutic effect is thought to be related to the ability of colchicine to disrupt microtubules and to concentrate in leukocytes, especially granulocytes, where it can reach high concentrations, even at low oral doses. Neutrophilic inflammation has been reported in FB cases, [8][9][10] as in our case. This neutrophilic inflammation can predispose to a colchicine response.…”

Section: Discussionsupporting

confidence: 71%

Successful Colchicine Therapy in a Patient With Follicular Bronchiolitis Presumed to Be Asthma

Göksel¹,

Nart²,

Ergönül

et al. 2015

Respir Care

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Follicular bronchiolitis (FB) is a rare small-airway pathology that is associated mainly with connective tissue diseases. This case report presents a new, diagnosed, different airway disease in a non-smoker with rheumatoid arthritis in remission who was treated for presumed asthma, but was not controlled. She was ultimately diagnosed with FB after video-assisted thoracoscopic surgery. The clinical findings of FB were controlled successfully by colchicine after she did not respond to systemic steroid therapy. This is the first case report of FB associated with rheumatoid arthritis that responded to colchicine.

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Section: Discussionsupporting

confidence: 71%

Successful Colchicine Therapy in a Patient With Follicular Bronchiolitis Presumed to Be Asthma

Göksel¹,

Nart²,

Ergönül

et al. 2015

Respir Care

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“…HRCT demonstrates centrilobular peribronchial nodules <3 mm in size with branching structures corresponding to bronchial dilation and wall thickening; honeycombing is absent. Pathology shows hyperplastic lymphoid follicles with germinal centres adjacent to airways [65,66]. PFTs usually demonstrate a restrictive pattern, although obstruction may be noted as well.…”

Section: Lower Airway Involvementmentioning

confidence: 99%

Rheumatoid arthritis-associated lung disease

et al. 2015

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“…Hyperinflation is the most common abnormality and small nodules may be seen [24]. Although follicular bronchiolitis (FB) has also been described in RA and is said to be associated with reticulonodular opacities of the chest radiograph [25,26], no lesions consistent with FB were found in the three autopsy cases. Thus, this study suggested that the airway involvement in patients with RA could be divided into three kinds of bronchiolitis: DPB, OB and FB.…”

Section: Clinical Diagnostic Criteriamentioning

confidence: 99%

Diffuse panbronchiolitis in rheumatoid arthritis

Homma¹,

Kawabata²,

Kishi³

et al. 1998

Eur Respir J

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The association of progressive obliterative bronchiolitis (OB) with rheumatoid arthritis (RA) is uncommon but has been reported previously. Diffuse panbronchiolitis (DPB) is a unique inflammation principally affecting the respiratory bronchioli and has been reported mainly in Japanese adults. Recently, DPB has also been noted in patients with RA in Japan. Therefore, there might be considerable overlap in clinical features between DPB and OB associated with RA in Japan. The aim of this study was to evaluate the clinicopathological characteristics of bronchiolitis in patients with RA. Three RA patients clinically diagnosed as having DPB were evaluated. All patients underwent chest radiographs, pulmonary function tests (PFT) and post mortem examination. Clinical features in all patients were a history of productive cough, exertional dyspnoea, wheezing and/or coarse crackles. Chest radiographs showed small nodular shadows up to 2 mm in diameter with bronchiolectasis throughout both lungs in all patients. The PFT revealed marked obstructive impairment in all patients. All patients died of progressive respiratory failure. Pathologically, two out of the three cases were confirmed as DPB, while the remaining one case was confirmed as OB, because the primary obstructive lesions were in the respiratory bronchioli in the former and in the membranous bronchioli and the proximal small bronchi in the latter. Thus, the clinical features of DPB and OB were strikingly similar, but the histopathological features revealed distinct differences. This study demonstrated that there was considerable overlap in clinical features between diffuse panbronchiolitis and obliterative bronchiolitis associated with rheumatoid arthritis, suggesting that diffuse panbronchiolitis might be a new manifestation of rheumatoid arthritis. The differentiation of these two disease entities is significant in making decisions on their therapeutic modality and is possible by analysing the precise histopathological findings of the lung.

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Follicular Bronchiolitis Associated with Rheumatoid Arthritis.

Cited by 40 publications

References 9 publications

Successful Colchicine Therapy in a Patient With Follicular Bronchiolitis Presumed to Be Asthma

Successful Colchicine Therapy in a Patient With Follicular Bronchiolitis Presumed to Be Asthma

Rheumatoid arthritis-associated lung disease

Diffuse panbronchiolitis in rheumatoid arthritis

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