Follicular Bronchiolitis in Primary Ciliary Dyskinesia

Thalanayar, Prashanth M.; Holguín, Fernando

doi:10.21767/amj.2014.2102

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…B cells may be a key factor for CVID ILD as it is ameliorated by rituximab, potentially explaining its absence in XLA [37]. Infections have been associated with this ILD [31,[38][39][40][41] which did occur more frequently in CVID patients with history of pneumonia or bronchiectasis. However, this result differed from our previous work from a single center that did not find ILD to be associated with bronchiectasis or pneumonia [31].…”

Section: Discussionmentioning

confidence: 97%

Factors Beyond Lack of Antibody Govern Pulmonary Complications in Primary Antibody Deficiency

et al. 2019

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Purpose-Pulmonary complications occur frequently in primary antibody deficiency (PAD). While the impact of antibody deficiency may appear implicit for certain respiratory infections, immunoglobulin replacement therapy does not completely ameliorate pulmonary complications in PAD. Thus, there may be antibody-independent factors influencing susceptibility to respiratory disease in PAD, but these remain incompletely defined. Methods-We harnessed the multicenter US Immunodeficiency Network primary immunodeficiency registry to compare prevalence of asthma, bronchiectasis, interstitial lung disease (ILD), and respiratory infections between two forms of PAD: common variable immunodeficiency (CVID) and x-linked agammaglobulinemia (XLA). We also defined the clinical and immunological characteristics associated with ILD and asthma in CVID. Results-Asthma, bronchiectasis, ILD, pneumonia, and upper respiratory infections were more prevalent in CVID than XLA. ILD was associated with autoimmunity, bronchiectasis, and pneumonia as well as fewer B and T cells in CVID. Asthma was the most common chronic pulmonary complication and associated with lower IgA and IgM in CVID. Age of symptom onset or CVID diagnosis was unrelated with ILD or asthma.

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Section: Discussionmentioning

confidence: 97%

Factors Beyond Lack of Antibody Govern Pulmonary Complications in Primary Antibody Deficiency

et al. 2019

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“…While our understanding of the prevalence of typespecific bronchiolitis other than diffuse bronchiolitis among populations with PCD is insufficient at present, the pathology in PCD-related bronchiolitis has been suggestive of DPB (12). Interestingly, Thalanayar and Holguin reported a case of follicular bronchiolitis in a patient with PCD in which they proposed a revised approach to managing airway disease, including the type-specific bronchiolitis noted in this subset of PCD patients (13). The pathological findings in our four cases were compatible with DPB or PCD, and one patient showed the presence of constrictive bronchiolitis with PCD.…”

Section: Discussionmentioning

confidence: 99%

The Usefulness of a Transbronchial Lung Cryobiopsy for Diffuse Bronchiolitis

et al. 2021

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We herein report four cases of diffuse bronchiolitis proven by a transbronchial lung cryobiopsy (TBLC). Based on various aspects, including the pathological findings, we definitively diagnosed two patients with diffuse panbronchiolitis (DPB) and the other two with primary ciliary dyskinesia (PCD). One of the DPB patients had more severe peribronchiolar fibrosis than the other, and the disease course was refractory to macrolide therapy. One of the PCD patients was additionally diagnosed with combined constrictive bronchiolitis. This report highlights the importance of a TBLC in the differentiation of bronchiolitis, suggesting its utility for helping pulmonologists formulate a treatment strategy.

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Follicular Bronchiolitis in Primary Ciliary Dyskinesia

Cited by 2 publications

References 7 publications

Factors Beyond Lack of Antibody Govern Pulmonary Complications in Primary Antibody Deficiency

Factors Beyond Lack of Antibody Govern Pulmonary Complications in Primary Antibody Deficiency

The Usefulness of a Transbronchial Lung Cryobiopsy for Diffuse Bronchiolitis

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