Follicular carcinoma of the thyroid following radioactive iodine treatment for Graves’ disease

Staffurth, J.; Holl‐Allen, R. T. J.

doi:10.1136/pgmj.64.757.878

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…In the literature, there are few reports about thyroid cancer after RAI therapy for toxic nodulary or diffused goiter. Staffurth et al reported a folliculary thyroid cancer following RAI therapy for Graves' disease [5]. In their case, FTC derived 17 years after the RAI therapy.…”

Section: Discussionmentioning

confidence: 95%

“…In the literature, many reports have been published in terms of radiation induced thyroid malignancy after Chernobyl accident [3,4]. Likewise, it is reported that thyroid cancer can be developed after 131 I therapy for thyrotoxicos [5][6][7][8][9]. It is also reported that 131 I therapy for diagnostic purpose does not increase the risk of thyroid malignacy although it is commonly used [10].…”

Section: Introductionmentioning

confidence: 99%

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Papillary Thyroid Carcinoma Developments After Radioactive Iodine Treatment for Toxic Adenoma: A Case Report

Duran

2013

J Med Cases

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Radioiodine is an important radiopharmaceutical agent in nuclear medicine practice for the treatment of hyperthyroidism and differenciated thyroid cancer. One of the long term side effects of ionising radiation is the possibility of radiation induced malignancy. There are limited reports about malignancy after 131 I therapy for thyrotoxicosis. In this report, a case with papillary thyroid cancer after radioactive iodine (RAI) therapy for toxic thyroid nodule is presented. In this case, fine needle aspiration biopsy(FNAB) had not been done before RAI therapy and papillary carcinoma was detected four years later than the 444 MBq RAI therapy. The patient underwent bilateral total thyroidectomy and central neck dissection. After the surgery, the patient underwent 5550 MBq RAI for ablation. Summary, differentiated thyroid cancer can be found incidentally in toxic nodule or can be developed as a consequence of radioiodine therapy. FNAB must be performed for all the patients with hot or cold thyroid nodules before RAI therapy and all the patients taking RAI theraphy should be closely followed in terms of nodule growing and cancer development.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Papillary Thyroid Carcinoma Developments After Radioactive Iodine Treatment for Toxic Adenoma: A Case Report

Duran

2013

J Med Cases

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“…Staffurth et al reported a follicular thyroid cancer following RAI therapy for Graves' disease [4]. In their case, follicular thyroid cancer was derived 17 years after the RAI therapy.…”

Section: Discussionmentioning

confidence: 99%

“…One of the long term side effects of ionizing radiation is the possibility of radiation induced malignancy. In the literature, there are some reports which show that thyroid cancer can develop after 131 I therapy for thyrotoxicosis [4][5][6][7][8]. As there is no reported cancer case that developed from hot nodule, routine fine needle aspiration biopsy (FNAB) is not recommended by ATA [2].…”

Section: Introductionmentioning

confidence: 99%

Papillary thyroid carcinoma after radioactive iodine treatment for toxic thyroid nodule: Case report

Sevinç¹,

Karahan²,

Duran³

et al. 2018

Marmara Medical Journal

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Toksik tiroit nodülü için radyoaktif iyot tedavisinden sonra gelişen tiroit papiller karsinomu: Olgu sunumu ÖZ Amerikan Tiroit Derneği (ATA) toksik tiroit nodüllerinde ince iğne aspirasyon biyopsisi (İİAB) yapılmaksızın radyoaktif iyot (RAI) tedavisi önermektedir. Elli beş yaşında kadın hasta 2005 yılında tespit edilen tiroit sağ lobunda yerleşimli toksik nodül nedeniyle RAI tedavisi almış. Hastanın RAI öncesi yapılan İİAB sonucu benign tiroit nodülü olarak rapor edilmiş. Hastanın 8 yıl sonra yapılan kontrol ultrasonografisinde tiroit sağ lobda yerleşimli 15 mm çaplı solid nodül saptandı. Hastaya yapılan İİAB sonucu papiller karsinom açısından şüpheli olarak rapor edildi. Hastaya bilateral total tiroidektomi yapıldı. Histopatolojik incelemede nodülde papiller tiroit karsinomu tespit edildi.Bu vaka RAI sonrası karşılaştığımız ikinci papiller karsinom vakasıdır. Bu yazıda sunduğumuz olgu, RAI öncesi hastanın karsinomunun olmadığı ve kanser gelişiminin RAI tedavisi sonrası olduğu İİAB ile gösterilmiştir. Sonuç olarak, RAI tedavisi alan hastalar uzun dönemde karsinom gelişimi açısından yakın takip edilmelidir.

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“…Staffurth et al reported a case of follicular thyroid cancer 15 years after a small dose of radioactive iodine (4 mCi) for Graves' disease [18]. [19] that play a significant role in thyroid carcinogenesis and angiogenesis [20].…”

Section: Discussionmentioning

confidence: 99%

Rak tarczycy po terapii jodem radioaktywnym z powodu nadczynności tarczycy — opis serii przypadków i przegląd piśmiennictwa

Eyadeh

Al-Sarihin

Etewi

et al. 2017

Endokrynologia Polska

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Introduction: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI 131 treatment for hyperthyroidism and to report the index cases' characteristics and management Material and methods: A cohort of 264 patients who received RAI 131 treatment for different causes of thyrotoxicosis were followed up over a period of 18 years (1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014) by physical exam, radiological evaluation and serial thyroid function tests. Results: During the follow up period, three cases of thyroid cancer were identified. The prevalence of thyroid cancer was 1.136% of cases who received RAI 131 . The relative risk was 378.79 (95% CI: 76.8 < RR < 1868.23). The P value was < 0.0000004 and the SMR is 1.99/1000. Conclusions: The prevalence of thyroid cancer was 1.136% in the cohort of patients treated with RAI

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Follicular carcinoma of the thyroid following radioactive iodine treatment for Graves’ disease

Cited by 5 publications

References 10 publications

Papillary Thyroid Carcinoma Developments After Radioactive Iodine Treatment for Toxic Adenoma: A Case Report

Papillary Thyroid Carcinoma Developments After Radioactive Iodine Treatment for Toxic Adenoma: A Case Report

Papillary thyroid carcinoma after radioactive iodine treatment for toxic thyroid nodule: Case report

Rak tarczycy po terapii jodem radioaktywnym z powodu nadczynności tarczycy — opis serii przypadków i przegląd piśmiennictwa

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