Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

Meyerson, Howard; Awadallah, Amad; Pavlidakey, Peter; Cooper, Kevin D.; Honda, Kazuo; Miedler, John D.

doi:10.1038/modpathol.2012.124

Cited by 55 publications

(39 citation statements)

References 57 publications

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“…Patients with diffuse disease showed marked resistance to treatments, with only one case of complete remission after allogeneic hematopoietic stem cell transplantation. Other researchers reported similar cases as "mycosis fungoides expressing TFH-cell markers" (12,13). We believe that our case fits into this category, although our case showed epidermotropism (Fig.…”

Section: Discussionsupporting

confidence: 67%

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Primary Cutaneous Follicular Helper T-cell Lymphoma Treated with Allogeneic Bone Marrow Transplantation: Immunohistochemical Comparison with Angioimmunoblastic T-cell Lymphoma

Ohmatsu¹,

Sugaya²,

Fujita³

et al. 2014

Acta Derm Venerol

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Primary cutaneous follicular helper T (TFH)-cell lymphoma has recently been proposed, and is characterized by proliferation of malignant T cells expressing TFH-cell markers, such as CXCL13, accompanied by numerous reactive B cells. We report here a patient whose skin histology showed massive infiltration of both T and B cells, with a proliferation of arborizing high endothelial venules and follicular dendritic cells. Infiltrating T cells were positive for CXCL13, programmed death (PD)-1, inducible T-cell co-stimulator, and BCL-6. Southern blot analyses using DNA from the skin revealed monoclonality of both T and B cells. The patient had marked resistance to treatments, and complete remission was achieved only after allogeneic stem cell transplantation. The present case showed overlapping features with angio-immunoblastic T-cell lymphoma (AITL), although systemic symptoms were not observed. Further study is needed to define the criteria of this provisional entity, representing the cutaneous counterpart of the nodal follicular peripheral T-cell lymphoma or AITL.

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Section: Discussionsupporting

confidence: 67%

“…"Primary cutaneous ATIL" has not been proposed as a new entity, therefore we have to include this case in PTCL, NOS. However, several cases with "primary cutaneous TFH-cell lymphoma" or "mycosis fungoides expressing TFH-cell markers" have been reported recently (11)(12)(13). Immunohistochemical study has suggested that our case should fit into this category.…”

mentioning

confidence: 65%

Primary Cutaneous Follicular Helper T-cell Lymphoma Treated with Allogeneic Bone Marrow Transplantation: Immunohistochemical Comparison with Angioimmunoblastic T-cell Lymphoma

Ohmatsu¹,

Sugaya²,

Fujita³

et al. 2014

Acta Derm Venerol

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“…According to recent publications, the absence of a significant expression of PD1 and CXCL13 in MF was expected. 27,28 Finally, in our opinion, the B-cell component observed in the skin of our patients being more the result of a homing process than a true cutaneous localization of the B-cell malignant disease, our cases should much more be considered as discordant cutaneous lymphomas than as composite lymphomas. To conclude, both folliculotropic MF and pseudo-folliculotropic MF may occur in patients with small B-cell lymphoproliferations, especially B-CLL.…”

Section: Discussionmentioning

confidence: 79%

Folliculotropic T‐cell infiltrates associated with B‐cell chronic lymphocytic leukaemia or MALT lymphoma may reveal either true mycosis fungoides or pseudolymphomatous reaction: seven cases and review of the literature

Ingen‐Housz‐Oro¹,

Franck

Bénéton

et al. 2014

Acad Dermatol Venereol

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Folliculotropic T-cell infiltrates associated with B-cell malignancies can be either a true folliculotropic MF or a pseudo-MF. The distinction between both conditions cannot rely only on the histopathological aspect, but needs both a clinical pathological correlation and the search for a dominant T-cell clone. Whether the neoplastic T and B cells derive from a common ancestor or the T-cell proliferation is promoted by the underlying B-cell lymphoma remains unsolved, but interaction between B and T cell in the skin does not appear to be dependent on a TFH differentiation of the T-cell infiltrate.

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“…It is controversial if PD-1 expression itself changes with evolution of disease. CD10 was detected on 10–40% of CD4+ T-cells in MF, using flow cytometry on skin and blood specimens 22 . CXCL-13 may be more commonly found in Sezary patients.…”

Section: Immunophenotypic Variantsmentioning

confidence: 99%

Unusual variants of mycosis fungoides

Virmani¹,

Myskowski²,

Pulitzer³

2016

Diagnostic Histopathology

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Conventional presentations of mycosis fungoides may be diagnostically challenging, particularly in light of the controversial boundaries defining the disease. Variant presentations of this cutaneous T-cell lymphoma add a further layer of complexity, requiring a sophisticated and informed perspective when evaluating lymphoid infiltrates in the skin. Herein we discuss well-defined (WHO-EORTC) variants pagetoid reticulosis, granulomatous slack skin and folliculotropic mycosis fungoides as well as less well-defined morphologic/architectural variants, and divergent immunohistochemical presentations of this typically indolent T-cell lymphoproliferative disease.

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Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

Cited by 55 publications

References 57 publications

Primary Cutaneous Follicular Helper T-cell Lymphoma Treated with Allogeneic Bone Marrow Transplantation: Immunohistochemical Comparison with Angioimmunoblastic T-cell Lymphoma

Primary Cutaneous Follicular Helper T-cell Lymphoma Treated with Allogeneic Bone Marrow Transplantation: Immunohistochemical Comparison with Angioimmunoblastic T-cell Lymphoma

Folliculotropic T‐cell infiltrates associated with B‐cell chronic lymphocytic leukaemia or MALT lymphoma may reveal either true mycosis fungoides or pseudolymphomatous reaction: seven cases and review of the literature

Unusual variants of mycosis fungoides

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