Follicular dendritic cell sarcoma

Chan, John K.; Fletcher, Christopher D.�M.; Nayler, Simon; Cooper, K

doi:10.1002/(sici)1097-0142(19970115)79:2<294::aid-cncr13>3.0.co;2-w

Cited by 322 publications

(178 citation statements)

References 23 publications

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“…FDC sarcoma is a neoplasmatic proliferation of spindled to ovoid cells showing morphologic and immumophenotypic features of FDCs [5]. It is usually observed as lymphadenopathy, but it can also be present in a variety of extranodal sites and intra-abdominal organs, including the spleen [2].…”

Section: Discussionmentioning

confidence: 99%

Splenic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor

Vardas¹,

Manganas²,

Papadimitriou³

et al. 2014

Case Rep Oncol

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Inflammatory pseudotumor of the spleen with expression of follicular dendritic cell markers is an extremely rare lesion with only a few cases reported previously. The present study reports on an inflammatory pseudotumor of the spleen 10 × 8 × 7 cm in size that was incidentally found in a 61-year-old man and increased gradually in size during a period of 3 months. Abdominal ultrasonography revealed a well-circumscribed splenic mass, and abdominal computed tomography confirmed the presence of a well-circumscribed isodense lesion in the splenic hilum with inhomogenous enhancement in the early-phase images and no enhancement on delayed-phase contrast-enhanced images. Magnetic resonance imaging of the abdomen showed a well-defined isodense tumor on T1-weighted images with mildly increased signal intensity on T2-weighted images, and this is only the second study that provides MRI findings of this entity. The patient underwent an uncomplicated open splenectomy for definitive histologic diagnosis. Under microscopic examination, the lesion was an admixture of lymphocytes, plasma cells and spindle cells. In situ hybridization analysis for Epstein-Barr virus (EBV) revealed that most of the spindle cells were positive for EBV, and immunochemistry showed the expression of the follicular dendritic cell markers CD21, CD35 and CD23 within the tumor. The diagnosis of inflammatory pseudotumor-like follicular dendritic cell tumor was established.

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Section: Discussionmentioning

confidence: 99%

Splenic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor

Vardas¹,

Manganas²,

Papadimitriou³

et al. 2014

Case Rep Oncol

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“…Of note, the follicular dendritic cells sometimes show dysplastic features (Figure 2B), and instances of follicular dendritic cell sarcoma have been described. 16, 17 In fact, recent molecular studies demonstrated clonality in the stromal cells in hyaline vascular Castleman disease, and suggested that genetic alteration in stromal cells including FDCs may be the underlying cause of the disease. 18–20 …”

Section: Unicentric Castleman Diseasementioning

confidence: 99%

Multicentric Castleman disease: Where are we now?

Wang

Pittaluga

Jaffe

2016

Seminars in Diagnostic Pathology

106

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Multicentric Castleman disease (MCD) encompasses a spectrum of conditions that give rise to overlapping clinicopathological manifestations. The fundamental pathogenetic mechanism involves dysregulated cytokine activity, which causes systemic inflammatory symptoms as well as lymphadenopathy. The histological changes in lymph nodes resemble in part the findings originally described in the unicentric forms Castleman disease, both hyaline vascular and plasma cell variants. In MCD caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8), the cytokine over activity is caused by viral products, which can also lead to atypical lymphoproliferations and potential progression to lymphoma. In cases negative for KSHV/HHV8, so-called idiopathic MCD, the hypercytokinemia can result from various mechanisms, which ultimately lead to different constellations of clinical presentations and varied pathology in lymphoid tissues. In this article, we review the evolving concepts and definitions of the various conditions under the eponym of Castleman disease, and summarize current knowledge regarding the histopathology and pathogenesis of lesions within the MCD spectrum.

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“…FDC sarcoma (FDCS), first described by Monda et al 3 in 1986, is a rare neoplastic proliferation showing morphological and immunophenotypic features of FDC. It can occur at nodal and extra-nodal sites, which were first described by Chan et al 4 5 in the oral cavity. Metastatic disease has also been observed in the lymph nodes, lung and liver 2.…”

Section: Introductionmentioning

confidence: 95%

Follicular dendritic cell sarcoma of the tonsil

et al. 2013

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SUMMARYFollicular dendritic cell sarcoma (FDCS) is an uncommon tumour within the spectrum of histiocytic and dendritic cell neoplasms that can occur at nodal and extra-nodal sites. Besides being rare, these tumours are difficult to diagnose. A 72-year-old man with a painless mass in the right tonsil was admitted to the Mersin University Hospital. Tonsillectomy was performed. Microscopically, the tumour consisted of spindle-shaped cells with large oval to polygonal nuclei. Lymphocytes were scattered among the tumour cells. Immunohistochemically, the cells were positive for CD23 and vimentin. The tumour was diagnosed as FDCS with histological and immunohistochemical findings. Recognition of extranodal FDCS requires knowledge of this entity and to consider it during the diagnosis. Confirmatory immunohistochemical staining is essential for diagnosis. Correct characterisation of this neoplasm is important because of its potential for recurrence and metastasis. BACKGROUND

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Follicular dendritic cell sarcoma

Cited by 322 publications

References 23 publications

Splenic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor

Splenic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor

Multicentric Castleman disease: Where are we now?

Follicular dendritic cell sarcoma of the tonsil

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