Follicular dendritic cell sarcoma of lymph node—report of fine needle aspiration (FNA) cytological appearances

Ryley, N. G.; Bastert, J.; Ferguson, David J. P.; Payne, M. J.

doi:10.1046/j.1365-2303.1999.00164.x

Cited by 24 publications

(21 citation statements)

References 11 publications

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“…On cytological examination, both the Diff-Quik and Papanicolaou-stained smears in this case showed that the tumor cells were syncytial and discohesive clusters of epithelioid to spindled cells in a mixed inflammatory background similar to previously described cases of FDCS [2,[10][11][12][13]. The tumor cells had eosinophillic granular cytoplasm and indistinct cell borders.…”

supporting

confidence: 76%

A rare sarcoma diagnosed on fine needle aspiration in two patients with Castleman disease: Clinical cases with questions for students

Yu¹,

Kundu²

2014

Med podmladak

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C a se 1 :A 38 ye ar old fem ale pr ese nte d wi th a 3.6 x 1.8 cm pe ri-ao rti c ma ss an d ret rop eriton ea l lym ph ad en op ath y. Sh e ini tia lly pr ese nte d at an ou tsi de ins titu tio n wi th a lar ge rig ht su pr are na l ma ss sev en ye ars pr ior wh ich wa s dia gn os ed on co re ne ed le bio ps y as hy ali ne va scu lar Ca stl em an dis eas e. Aft er rec eiv ing ch em oth era py of ge mc ita bin e an d Ta xo ter e pa rti al rem iss ion wa s ach iev ed . Sh e su bs eq ue ntl y un de rw en t su rgi ca l ex cis ion of the rig ht su pr arena l ma ss an d rig ht kid ne y at M D An de rso n Ca nc er Ce nte r. Th e res ect ed sp eci me n sh ow ed lar ge sp ind le an d ep ith eli oid tum or cel ls in a ba ck gro un d of sm all ma tur e lym ph oc yte s. M an y tum or cel ls ha d pr om ine nt nu cle ar ps eu do inc lus ion s. Th ere we re als o are as wi th pr om ine nt pr oli fer ati on of pla sm a cel ls, wi th de po sit ion of am or ph ou s eo sin op hil ic ex tra cel lul ar ma teria l. Ad dit ion all y, foc al dy str op hic ca lci fic ati on wa s pr ese nt. In sit u hy br idi zat ion for ka pp a an d lam bd a im mu no glo bu lin lig ht-ch ain sh ow ed a po lyt yp ic pa tte rn of po sit ivi ty in pla sm a cel ls for ka pp a an d lam bd a lig ht ch ain s. Th e sp ind led an d ep ith eli oid tum or cel ls we re po sitiv e for CD 21 , CD 35 , clu ste rin an d vim en tin by im mu no his toc he mi str y. Th e im ag es fro m the asp ira te sm ear s an d cel l blo ck are sh ow n be low (im ag e 1-3 ). Image 1. Pap stained smear, 20x (A), 40x (B) and 60x (C) magnification.

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supporting

confidence: 76%

A rare sarcoma diagnosed on fine needle aspiration in two patients with Castleman disease: Clinical cases with questions for students

Yu¹,

Kundu²

2014

Med podmladak

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“…CD21 and CD35 markers are most specific and can be performed on formalin fixed paraffin embedded materials [27], with almost universal positivity [25,27,28,35,[38][39][40][41][42][43][44][45][46][47][48][49]. It is important to note that frequent pathological mimickers such as thymoma, meningioma, and malignant fibrous histiocytoma lack these markers.…”

Section: Follicular Dendritic Cell Tumor/sarcomamentioning

confidence: 99%

“…The clinical presentation varies according to the location of the primary tumor. Nodal tissue involvement occurs in the hilar [37], mediastinal [27,47,59], para-aortic [47], and mesenteric areas [27], but with a greater tendency in cervical, axillary, and supraclavicular nodes [25,27,[29][30][31]36,37,42,48,49,60,61]. FDCT/ S has also been described in other lymphoid tissues including the tonsils [25, 27,29,[61][62][63], nasopharynx [39], paraphrynx [61], and the spleen [27,29].…”

Section: Clinical Coursementioning

confidence: 99%

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Dendritic cell neoplasms: An overview

et al. 2007

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Dendritic cell neoplasms are rare tumors that are being recognized with increasing frequency. They were previously classified as lymphomas, sarcomas, or histiocytic neoplasms. The World Health Organization (WHO) classifies dendritic cell neoplasms into five groups: Langerhans' cell histiocytosis, Langerhans' cell sarcoma, Interdigitating dendritic cell sarcoma/tumor, Follicular dendritic cell sarcoma/tumor, and Dendritic cell sarcoma, not specified otherwise (Jaffe, World Health Organization classification of tumors 2001; 273–289). Recently, Pileri et al. provided a comprehensive immunohistochemical classification of histiocytic and dendritic cell tumors (Pileri et al., Histopathology 2002;59:161–167). In this article, a concise overview regarding the pathological, clinical, and therapeutic aspects of follicular dendritic, interdigitating dendritic, and Langerhans' cell tumors is presented. Am. J. Hematol. 82:924–928, 2007. © 2007 Wiley‐Liss, Inc.

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“…a Expression patterns for FDC and IDC sarcomas based on consensus of previously reported cases (8,12,17,22,23,26,27,30,44,45). b Indicates that immunohistochemical staining pattern was correlated with that seen by cDNA array transcriptional analysis of short-term stromal cell cultures of tumor and of fibroblastic stroma from non-neoplastic lymph node.…”

Section: Gene Expression Analysismentioning

confidence: 99%

Reticulum Cell Sarcoma of Lymph Node with Mixed Dendritic and Fibroblastic Features

et al. 2001

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We report a case of clinically aggressive reticulum cell sarcoma with mixed follicular dendritic cell (FDC) and fibroblastic reticular cell (FRC) features. Histologically, the tumor was confined to lymph nodes occurring as a multifocal epithelioid and spindle cell proliferation with appreciable mitotic rate and numerous admixed non-neoplastic B-cells. IDCs have a primary function in antigen presentation in the interfollicular zones of the node and differentiate from Langerhans cells migrating from skin or from bone marrow-derived precursors (2). FRCs form a diffuse extrafollicular network that guides cell migration within the lymph node (7). Nodal sarcomas have been described that are postulated to arise from each of these different reticular cell populations. These include CD21-and CD35-positive FDC sarcoma (8) and S100-positive IDC sarcoma (9 -12). Recently, several groups have reported nodal sarcomas of possible FRC lineage (13-15). However, some of these tumors have been incompletely studied, with only limited antigen profiling and ultrastructural analysis. Thus, the range of features associated with FRC sarcoma is not yet clearly delineated. Here, we report the first morphologic, extended phenotypic and genotypic characterization of a case of primary lymph node sarcoma with mixed dendritic and fibroblastic features. METHODSHematoxylin and eosin-stained histologic sections from the original biopsy specimen obtained at an outside hospital were compared with the initial resection and tumor recurrence specimens, both done at our institution. Clinical information was obtained from the medical record.

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Follicular dendritic cell sarcoma of lymph node—report of fine needle aspiration (FNA) cytological appearances

Cited by 24 publications

References 11 publications

A rare sarcoma diagnosed on fine needle aspiration in two patients with Castleman disease: Clinical cases with questions for students

A rare sarcoma diagnosed on fine needle aspiration in two patients with Castleman disease: Clinical cases with questions for students

Dendritic cell neoplasms: An overview

Reticulum Cell Sarcoma of Lymph Node with Mixed Dendritic and Fibroblastic Features

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