Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review

Martins, Paulo N.; Reddy, Sanjay S.; Martins, Ann-Britt; Facciuto, Marcelo

doi:10.1016/s1499-3872(11)60076-3

Cited by 36 publications

(35 citation statements)

References 12 publications

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“…The reported clinical presentation includes malaise, weight loss, anaemia, epigastric discomfort, fever, gastrointestinal discomfort and incidental findings during radiological examination. To the best of our knowledge, our presented case is the first with paraneoplastic arthritis syndrome as the first and unique symptom.…”

mentioning

confidence: 77%

Paraneoplastic arthritis as first symptom of a liver inflammatory pseudotumor‐like follicular dendritic cell sarcoma

Sandri

Colasanti

Vennarecci

et al. 2016

Liver International

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mentioning

confidence: 77%

Paraneoplastic arthritis as first symptom of a liver inflammatory pseudotumor‐like follicular dendritic cell sarcoma

Sandri

Colasanti

Vennarecci

et al. 2016

Liver International

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“…Most cases of FDC sarcoma are of unknown aetiology, however associations exist with Castleman’s disease, myasthenia gravis and paraneoplastic pemphigus 2. FDC sarcoma is a rare primary sarcoma of the liver which, in total, constitutes less than 0.1% of primary liver tumours 4. Presenting symptoms of an intra-abdominal FDC sarcoma are non-specific and may include abdominal pain, malaise and weight loss 5.…”

Section: Discussionmentioning

confidence: 99%

“…A subtype of FDC sarcoma called the inflammatory pseudotumour (IPT)-like subtype occurs almost exclusively in the liver and spleen6 and has unique histological findings including cellular growth into fascicles and sheets, vesicular nuclei, a background containing lymphocytes and plasma cells, and Reed-Sternberg-like nuclear atypia 2. The IPT-like FDC sarcoma is strongly associated with Epstein-Barr virus (EBV) positivity, female gender preference2 4 and significant inflammatory cell infiltration 4. A likely culprit for the strong association of EBV with FDC sarcoma is LMP-1, an EBV oncogene capable of exerting cellular changes, with variants found more often in persons of Asian race 6.…”

Section: Discussionmentioning

confidence: 99%

Follicular dendritic cell sarcoma of the porta hepatis

Patel¹,

Piper

Wang

2018

BMJ Case Reports

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Follicular dendritic cell (FDC) sarcoma is a very rare neoplasm which commonly involves the lymph nodes and less commonly involves extranodal organs such as the liver. Most cases of FDC sarcoma are idiopathic, however some cases are associated with other disease states. Management of FDC sarcoma is primarily focused on surgical resection of the mass, and secondarily focused on radiotherapy, chemotherapy and/or biologic pharmacotherapy. We report the case of a patient who was found to have FDC sarcoma presenting as an obstructing mass of the porta hepatis, a manifestation which does not appear to be reported in the literature.

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“…Hepatic FDC tumor is a rare neoplasm with only 24 cases reported in the English literature to date (4)(5)(6)(7)(8). IPT-like FDC tumors of liver are even more rare, and the clinicopathological nature of this type of disease remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Hepatic inflammatory pseudotumour-like follicular dendritic cell tumor: A case report

Zhang

Zhu

et al. 2017

Molecular and Clinical Oncology

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Abstract. Hepatic inflammatory pseudotumor (IPT)-like follicular dendritic cell (FDC) tumor is a rare neoplasm. We herein report the case of 19-year-old female patient with an IPT-like FDC tumor and summarize 24 cases of hepatic FDC tumors previously reported in the English literature. The patient presented with complaints of abdominal discomfort, without significant laboratory abnormalities, and underwent surgical removal of a hepatic tumor. The resected tumor was 6 cm in the longest diameter and the tumor cells were positive for CD21, CD35 and Epstein-Barr virus (EBV). The postoperative course was uneventful and there have been no metastases or recurrence during 1 year of follow-up. The majority of the cases of hepatic IPT-like FDC tumors have a female predominance and exhibit an association with EBV infection. Their clinical manifestations and image findings are usually non-specific and the diagnosis of this disease mainly relies on pathology.

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Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review

Cited by 36 publications

References 12 publications

Paraneoplastic arthritis as first symptom of a liver inflammatory pseudotumor‐like follicular dendritic cell sarcoma

Paraneoplastic arthritis as first symptom of a liver inflammatory pseudotumor‐like follicular dendritic cell sarcoma

Follicular dendritic cell sarcoma of the porta hepatis

Hepatic inflammatory pseudotumour-like follicular dendritic cell tumor: A case report

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