Follicular dendritic cell sarcoma of axillary lymph node: A rare entity presenting with diagnostic challenge

Follicular dendritic cells

“…Since then, only a few hundred cases representing about 0.4% of soft tissue sarcomas (Monda et al, 1986) reported sporadically worldwide (Bouriga et al, 2018;Duan et al, 2017;Tomonaga, 2009). It develops when FDCs in the GCs of lymphoid follicles proliferate and undergo sarcomatous changes (Chen et al, 2016;Pang et al, 2016) M. Allen, 1997;Jain et al, 2017;Lu et al, 2020;Mohanty et al, 2018).…”

“…L. Wu et al, 2019;Xin & Kong, 2018;Zhang et al, 2020). Other sites included axillary lymph nodes (Sahay et al, 2019), inguinal, and intraabdominal lymph nodes (Gaffney et al, 2000;Loo et al, 2001;Mohanty et al, 2018;Pang et al, 2016).…”

“…It was classified by the World Health Organization under histiocytic and DC neoplasms (Munguía‐Fuentes et al, 2020), predominantly affecting young to middle‐aged adults with no sex predilection. Although it is intermediate‐grade malignancy, it has significant metastatic and recurrence potential (T. M. Allen, 1997; Jain et al, 2017; Lu et al, 2020; Mohanty et al, 2018).…”

“…In head and neck FDCS was detected in the soft palate, parotid gland, retromolar trigone, parapharyngeal space, in the nasopharynx, chest, breast, thyroid, cervical, submandibular, and tonsilar (Bao et al, 2021; Dusenbery & Watson, 1996; Dutta et al, 2018; Guiter et al, 2000; Hanfee et al, 2021; Ilonen et al, 2021; Kaur et al, 2021; Moz et al, 2004; Pyo et al, 2012; Tokyol et al, 2008; Wright et al, 1997; B. Wu et al, 2019; Y. L. Wu et al, 2019; Xin & Kong, 2018; Zhang et al, 2020). Other sites included axillary lymph nodes (Sahay et al, 2019), inguinal, and intraabdominal lymph nodes (Gaffney et al, 2000; Loo et al, 2001; Mohanty et al, 2018; Pang et al, 2016). Several extranodal sites were reported in the neck, tonsil (Bao et al, 2021; Mohanty et al, 2003; Nayler et al, 1996; Pang et al, 2016; Tokyol et al, 2008; B. Wu et al, 2019), mediastinum (Hu et al, 2016; Rademakers, 1992; Y. L. Wu et al, 2019), palate (Hu et al, 2016), spleen (Hang et al, 2017; Wang et al, 2014, 2016), pancreas (Wang et al, 2016), gastrointestinal tract (Liang et al, 2016), mesentery (Shaw et al, 2014; J. Wang et al, 2005; Xin & Kong, 2018), and urinary bladder (Chang et al, 2017).…”