Follicular dendritic cell sarcoma: two rare case series and a brief review of the literature

Ma, Yanhe; Sun, Jian; Yuan, Dandan; Liu, Jie

doi:10.2147/ott.s86502

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…[1] Immunohistochemical characteristics that respond positively in CD21, CD23, and CD35 markers were employed to detect the tumour. [5,8,9] The majority of those affected were young to middle-aged people, with an average age of 43.8 years and a range of 14 to 76 years.…”

Section: Discussion: Pathogenesis and Clinical Presentationmentioning

confidence: 99%

CT features, Pathological findings and Clinical data of Follicular Dendritic Cell Sarcoma in the Mediastinum: Case Report and Literature Review

Wu¹,

Yang²,

Musa³

et al. 2023

JRRS

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Follicular dendritic cell sarcoma (FDC sarcoma) is an uncommon neoplasm with few reported cases. We investigated the Computed Tomography (CT) appearance and pathological findings in a 43years-old lady diagnosed with mediastinal FDC sarcoma using pathological tests. It's usually confused with lymphoma. The literature was reviewed for previous FDC sarcoma reports. FDC sarcoma should be considered in asymptomatic patients with mediastinal lymph node lesions with a diameter of more than 1 cm and appear as an ill-defined mass with an arborizing pattern of necrosis. CD21(+) is a specific immunohistochemically marker for determining the pathological diagnosis of FDC sarcoma.

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Section: Discussion: Pathogenesis and Clinical Presentationmentioning

confidence: 99%

CT features, Pathological findings and Clinical data of Follicular Dendritic Cell Sarcoma in the Mediastinum: Case Report and Literature Review

Wu¹,

Yang²,

Musa³

et al. 2023

JRRS

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Section: Discussion: Pathogenesis and Clinical Presentationmentioning

confidence: 99%

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2023

JRRS

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Follicular dendritic cells sarcoma (FDC sarcoma) are mesenchymal-derived dendritic cells located in B-follicles, where they play a pivotal role in triggering and maintaining B-cell adaptive immune response. It is an uncommon tumor with few reported cases. Using pathological tests, we investigated the computed tomography (CT) appearance, positron emission tomography-computed tomography (PET-CT), and pathological findings in a 43-year-old woman diagnosed with mediastinal FDC sarcoma which usually overlaps with lymphoma. Previous literature reports on FDC sarcoma were reviewed. FDC sarcoma should be considered in asymptomatic patients with mediastinal lymph node lesions with a diameter of more than 1cm and appears as an illdefined mass with an arborising pattern of necrosis. The complement receptor CD21(+) is an immunohistochemically specific marker for determining the pathological diagnosis of FDC sarcoma. This case report aims to highlight imaging features to facilitate this rare entity's diagnosis and treatment options.

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“…Other regimens that were used include those that are used for lymphomas (ifosfamide, carboplatin and etoposide (ICE) [ 11 , 13 , 24 ], dexamethasone, cytarabine and cisplatin (DHAP) [ 9 , 13 ], etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (EPOCH) [ 10 ], etoposide, methylprednisolone, cytarabine and cisplatin (ESHAP) [ 13 , 27 , 30 , 31 ], ifosfamide, gemcitabine, vinorelbine and prednisolone (IGEV) [ 19 ]) and soft tissue sarcomas (doxorubicin, ifosfamide and mesna (AIM) [ 14 , 20 , 21 , 31 ], ifosfamide and etoposide (IE) [ 13 ], gemcitabine and docetaxel (Gem/Doce) [ 13 , 22 , 23 , 32 ]). Notably, all three sarcoma regimens have been demonstrated to induce complete response, with the combination of gemcitabine and docetaxel resulting in complete response in the third-line setting in one case [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Follicular Dendritic Cell Sarcoma of the Tonsil: A Multimodality Approach

et al. 2020

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Follicular dendritic cell sarcoma (FDCS) accounts for < 0.4% of soft tissue sarcomas. Only 35 cases of tonsillar FDCS have been reported, and majority had localized presentation. We present a case of FDCS of the tonsil, wherein a well-coordinated trimodality approach provided good disease control in advanced disease. A 53-year-old man presented with a painless and enlarging neck mass of 11-month duration, with no other symptoms. Close examination revealed a 10 × 5 cm mass at the left carotid triangle, and a 3.2 × 2.2 cm mass at the left tonsillar fossa. Imaging revealed the tumor to be unresectable due to its attachment to the great vessels. There were no distant metastases. Biopsy and immunohistochemistry were initially deemed consistent with an undifferentiated sarcoma. Palliative chemotherapy was given using single agent doxorubicin and subsequent dacarbazine, resulting in partial response and stable disease, respectively. Pathological re-evaluation was pursued because of the uncharacteristic slow progression of the tumor, revealing diffuse positivity for CD21 and negative for CD1A and CD34, consistent with FDCS. The patient underwent three cycles of gemcitabine plus docetaxel resulting in 50% regression. This allowed dissection of level IB-V lymph nodes and subsequent radiotherapy for the neck and tonsillar mass, with weekly gemcitabine as a radiosensitizer. Evaluation 8 months post-treatment showed no signs of disease progression. Treatment-related complications included radiation dermatitis and swallowing dysfunction, which both resolved on follow-up. This case highlights the multidisciplinary management of a rare type of sarcoma in an uncommon ana-tomic location. Precise pathologic diagnosis is important in soft tissue sarcoma because of its therapeutic implications. For FDCS, effective response may still be achieved in the third-line setting.

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Follicular dendritic cell sarcoma: two rare case series and a brief review of the literature

Cited by 8 publications

References 24 publications

CT features, Pathological findings and Clinical data of Follicular Dendritic Cell Sarcoma in the Mediastinum: Case Report and Literature Review

CT features, Pathological findings and Clinical data of Follicular Dendritic Cell Sarcoma in the Mediastinum: Case Report and Literature Review

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Follicular Dendritic Cell Sarcoma of the Tonsil: A Multimodality Approach

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