Follicular Dendritic Cells and Germinal Centers

Yj, Liu; Grouard, Géraldine; O, de Bouteiller; Banchereau, Jacques

doi:10.1016/s0074-7696(08)62508-5

Cited by 133 publications

(82 citation statements)

References 162 publications

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“…Finally, the Ag-selected (either or not class switched) B cells will differentiate into memory B cells or Ab-producing plasma cells. [25][26][27] SHM and CSR essentially depend on the B-cellspecific enzyme activation-induced cytidine deaminase (AID). As both processes are associated with the occurrence of singleand double-stranded DNA breaks, it is presumed that they predispose to chromosomal translocations.…”

Section: Somatic Ig Gene Alterations and Lymphomagenesismentioning

confidence: 99%

“…27 In the GC, the rapidly expanding B cells are critically dependent on BCR signaling; cells that lose contact with Ag owing to affinitylowering IgV mutations, rapidly die by apoptosis. [25][26][27] In addition, based on BCR ablation experiments in mice, it has become clear that the mere expression of an intact BCR generates autonomous survival signals, also designated as tonic BCR signaling. 72,73 Inducible interference of the signaling capacity of the BCR-associated Iga, in transgenic mice, showed that the BCR maintenance signal is transmitted through the Iga/ Igb heterodimer.…”

Section: The Role Of the B-cell Antigen Receptor Complex In Fl Develomentioning

confidence: 99%

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Molecular pathways in follicular lymphoma

2006

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Follicular lymphoma (FL) is one of the most common B-cell non-Hodgkin's lymphomas. The initiating genetic event found in B90% of FL is the t(14;18), causing constitutive expression of the antiapoptotic BCL-2 protein. The exact secondary alterations leading to full FL development are still poorly defined. In this review, we address (i) the genetic pathways associated with tumorigenesis and progression of FL, (ii) the role of micro-environmental factors with emphasis on B-cell receptor ligands and (iii) lymphoma models in mice and what they teach us about lymphomagenesis in man.

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Section: Somatic Ig Gene Alterations and Lymphomagenesismentioning

confidence: 99%

Section: The Role Of the B-cell Antigen Receptor Complex In Fl Develomentioning

confidence: 99%

Molecular pathways in follicular lymphoma

2006

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“…T cells make multiple, transient (2-3 minute) contacts with DCs during T cell repertoire scanning (Miller et al, 2004b). Cognate T cells can bind for longer times to an antigen-bearing DC (10-15 hours) and later form clusters or swarms of T cells (Liu et al, 1996). These longer interactions are associated with secretion of interleukin-2 and interferon-γ (D' Souza and Lefrancois, 2004).…”

Section: Introductionmentioning

confidence: 99%

A comparison of random vs. chemotaxis-driven contacts of T cells with dendritic cells during repertoire scanning

Riggs

Walts

Perry

et al. 2008

Journal of Theoretical Biology

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Generating adaptive immunity after infection or immunization requires physical interactions within a lymph node (LN) T-zone between antigen-bearing dendritic cells (DCs) that arrive from peripheral tissues and rare cognate T cells entering via high endothelial venules (HEVs). This interaction results in activation of cognate T cells, expansion of that T cell lineage and their exit from the LN T zone via efferent lymphatics (ELs). How antigen-specific T cells locate DCs within this complex environment is controversial, and both random T cell migration and chemotaxis have been proposed. We developed an agent-based computational model of a LN that captures many features of T cell and DC dynamics observed by two-photon microscopy. Our simulations matched in vivo two-photon microscopy data regarding T cell speed, short-term directional persistence of motion and cell motility. We also obtained in vivo data regarding density of T cells and DCs within a LN and matched our model environment to measurements of the distance from HEVs to ELs. We used our model to compare chemotaxis with random motion and showed that chemotaxis increased total number of T cell DC contacts, but decreased unique contacts, producing fewer activated T cells. Our results suggest that, within a LN T-zone, a random search strategy is optimal for a rare cognate T cell to find its DC match and maximize production of activated T cells. KeywordsAgent-based computational model; T cell repertoire scanning; two-photon microscopy; lymph node model

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“…10 Under physiological conditions, FDC form the framework for GC, 11,12 and are deemed to play key roles in the maturation of antigen activated B cells. 13 FDC also provide networks for the nodules of follicular lymphoma, 14 which may reflect an important role in the growth of follicular lymphoma cells.…”

Section: Introductionmentioning

confidence: 99%